Results 101 to 110 of about 11,777 (278)

The role of atrial natriuretic peptide to attenuate inflammation in a mouse skin wound and individually perfused rat mesenteric microvessels. [PDF]

, 2016
We tested the hypothesis that the anti-inflammatory actions of atrial natriuretic peptide (ANP) result from the modulation of leukocyte adhesion to inflamed endothelium and not solely ANP ligation of endothelial receptors to stabilize endothelial barrier
Adamson, Roger H, Clark, Joyce F, Curry, Fitz-Roy E, Jiang, Yanyan, Kim, Min-Ho, Simon, Scott I   +5 more
core   +2 more sources

Differential Effects of PDE4 Inhibitors on Cortical Neurons and T-Lymphocytes

Journal of Pharmacological Sciences, 2008
Inhibitors of PDE4 (cAMP-specific phosphodiesterase) induce side effects, including nausea and emesis, that limit their therapeutic potential. We investigated the function of two catalytically active conformations of PDE4 (a low-affinity conformer ...
Ryo Hirose, Haruhiko Manabe, Koji Yanagawa, Etsuo Ohshima, Michio Ichimura   +4 more
doaj  

Inhibition of Phosphodiesterase-4 (PDE4) activity triggers luminal apoptosis and AKT dephosphorylation in a 3-D colonic-crypt model [PDF]

, 2012
BACKGROUND: We previously established a three-dimensional (3-D) colonic crypt model using HKe3 cells which are human colorectal cancer (CRC) HCT116 cells with a disruption in oncogenic KRAS, and revealed the crucial roles of oncogenic KRAS both in ...
Darren R Tyson, Hiroshi Matsuzaki, Keiko Doi, Masahide Kuroki, Masahiro Ogawa, Masato Hamabashiri, Senji Shirasawa, Shingo Miyamoto, Takahiro Fujimoto, Takeharu Ota, Toshiyuki Tsunoda, Yasuhiro Yoshida, Yoko Tanaka   +12 more
core   +1 more source

Protective Effect of Administered Rolipram against Radiation-Induced Testicular Injury in Mice

The World Journal of Men's Health, 2015
Purpose Pelvic irradiation for the treatment of cancer can affect normal cells, such as the rapidly proliferating spermatogenic cells of the testis, leading to infertility, a common post-irradiation problem.
Wan Lee, Y. Son, H. Jang, M. Bae, Jungki Kim, Dongil Kang, J. Kim   +6 more
semanticscholar   +1 more source

Journey through the spectacular landscape of melanocortin 1 receptor

Pigment Cell &Melanoma Research, Volume 37, Issue 5, Page 667-680, September 2024.
Epidermal keratinocytes synthesize and secrete α‐melanocyte stimulating hormone (α‐MSH) and adrenocorticotropic hormone (ACTH). These act as agonists of the melanocortin 1 receptor expressed on the cell surface of human melanocytes. Binding of these physiological agonists or synthetic α‐MSH analogs to human MC1R activates the cAMP pathway, leading to ...
P. R. Upadhyay, V. B. Swope, R. J. Starner, L. Koikov, Z. A. Abdel‐Malek   +4 more
wiley   +1 more source

Inhibition of phosphodiesterase 4 reduces ethanol intake and preference in C57BL/6J mice

Frontiers in Neuroscience, 2014
Some anti-inflammatory medications reduce alcohol consumption in rodent models. Inhibition of phosphodiesterases (PDE) increases cAMP and reduces inflammatory signaling.
Yuri A. Blednov, Jillian M. Benavidez, Mendy eBlack, R. Adron eHarris   +3 more
doaj   +1 more source

The protein kinase C inhibitor, Ro-31-7459, is a potent activator of ERK and JNK MAP kinases in HUVECs and yet inhibits cyclic AMP-stimulated SOCS-3 gene induction through inactivation of the transcription factor c-Jun [PDF]

, 2012
Induction of the suppressor of cytokine signalling 3 (SOCS-3) gene is vital to the normal control of inflammatory signalling. In order to understand these processes we investigated the role of the proto-oncogene component of the AP-1 transcription factor
Anna McIlroy, Baillie, Barclay, Beltman, Borland, Borland, Boyle, Chloe Stoyle, Croker, Croker, Derijard, Dieter, Franklin, Gillian Lappin, Gschwendt, Jo, John D. Pediani, Jolanta Wiejak, Julia Dunlop, Kamura, Liu, Matthews, Minden, Parnell, Sands, Shan Gao, Stephen J. Yarwood, Tamiya, Toullec, White, Woolson, Yarwood   +31 more
core   +1 more source

Depressive symptom as a risk factor for cirrhosis in patients with primary biliary cholangitis: Analysis based on Lasso‐logistic regression and decision tree models

Brain and Behavior, Volume 14, Issue 8, August 2024.
This study demonstrated a high rate of depressive symptoms in patients with PBC. HAMD‐17 score was negatively associated with C4 levels and positively associated with levels of ALP, GGT, TB, IgG, and IgM. Elevated HAMD‐17 score was a discriminating factor for high risk of cirrhosis in Lasso‐logistic regression and decision tree models.
Simin Zhou, Jiwen Li, Jiangpeng Liu, Shijing Dong, Nian Chen, Ying Ran, Haifeng Liu, Xiaoyi Wang, Hui Yang, Man Liu, Hongyu Chu, Bangmao Wang, Yanni Li, Liping Guo, Lu Zhou   +14 more
wiley   +1 more source

Nausea: Current knowledge of mechanisms, measurement and clinical impact [PDF]

, 2015
Nausea is a subjective sensation, which often acts as a signal that emesis is imminent. It is a widespread problem that occurs as a clinical sign of disease or as an adverse effect of a drug therapy or surgical procedure.
Aapro, Alphin, Andrews, Andrews, Andrews, André, Beleslin, Chelen, Chen, Cluny, Coil, Conder, Cross-Mellor, Cubeddu, Cubeddu, Cubeddu, Cubeddu, Cullen, Davidson, de la Puente-Redondo, Diemunsch, Doweck, Elwood, Fan, Foss, Fredrikson, Fredrikson, Gralla, Hahn, Hannah Kenward, Hay Kraus, Hickman, Hikasa, Holmes, Horn, Horn, Hornby, Hu, Japundzic-Zigon, Jenns, Jonathan Elliott, Karine Savary-Bataille, Kenward, Kim, Koch, Koch, Koivuranta, Kowalski, Krawiec, Kretzing, Kretzing, Kristal, Kvale, Lacasse, Le Bars, Leeser, Limebeer, Limebeer, Limebeer, Limebeer, Limebeer, Limebeer, Lucot, Ludovic Pelligand, Mantione, Mayer, Medleau, Melzack, Miller, Minami, Minami, Morrow, Morrow, Morrow, Muth, Napadow, Otto, Parker, Parker, Parker, Parker, Poli-Bigelli, Quimby, Rau, Ritter, Rock, Roila, Rossmeisl, Rowe, Sanger, Sanger, Schwartz, Sedlacek, Shelke, Soderpalm, Stern, Tatewaki, Tramer, Vaha-Vahe, Villablanca, Watson, Yamakuni, Yamamoto, Yap, Yu   +104 more
core   +1 more source

Nicotine Impairs Smooth Muscle cAMP Signaling and Vascular Reactivity

Microcirculation, Volume 31, Issue 6, August 2024.
ABSTRACT Objective This study aimed to determine nicotine's impact on receptor‐mediated cyclic adenosine monophosphate (cAMP) synthesis in vascular smooth muscle (VSM). We hypothesize that nicotine impairs β adrenergic–mediated cAMP signaling in VSM, leading to altered vascular reactivity.
Navid Singhrao, Victor A. Flores‐Tamez, Yumna A. Moustafa, Gopireddy R. Reddy, Abby E. Burns, Kent E. Pinkerton, Chao‐Yin Chen, Manuel F. Navedo, Madeline Nieves‐Cintrón   +8 more
wiley   +1 more source