Results 121 to 130 of about 11,777 (278)

Modulation in the expression of SHP-1, SHP-2 and PTP1B due to the inhibition of MAPKs, cAMP and neutrophils early on in the development of cerulein-induced acute pancreatitis in rats [PDF]

, 2014
The protein tyrosine phosphatases (PTPs) SHP-1, SHP-2 and PTP1B are overexpressed early on during the development of cerulein -induced acute pancreatitis (AP) in rats, and their levels can be modulated by some species of mitogen-activated protein kinases
Calvo, José J., García-Hernández, Violeta, Matellán, Laura, Sarmiento, Nancy, Sánchez-Bernal, Carmen, Sánchez-Yagüe, Jesús   +5 more
core   +1 more source

Modulation of oxazolone-induced hypersensitivity in mice by selective PDE inhibitors

Mediators of Inflammation, 1995
The effects of PDE inhibitors on oxazolone-induced contact hypersensitivity (CS) were studied in mice. Rolipram, Ro 20-1724 and theophylline dose dependently inhibited CS but none caused >53% inhibition. ED30 values at 24 h before challenge for rolipram,
I. Moodley, Y. Sotsios, B. Bertin
doaj   +1 more source

Phosphodiesterase 4B is essential for lipopolysaccharide-induced CC chemokine ligand 3 production in mouse macrophages

Journal of Medical Sciences, 2015
Background: Phosphodiesterase 4 (PDE4) inhibitors negatively modulate many inflammatory responses, and some of these pharmacological effects are mediated by inhibition of PDE4B in inflammatory cells.
Ciou-Rong Lai, Huan-Chu Lo, Yi-Ling Chen, Jing-Xing Yang, Shiau-Li Ding, Hsian-He Hsu, Marco Conti, Chin-Pyng Wu, S L Catherine Jin   +8 more
doaj   +1 more source

Stabilized low-n amyloid-ß oligomers induce robust novel object recognition deficits associated with inflammatory, synaptic, and GABAergic dysfunction in the rat [PDF]

, 2018
YesBackground:With current treatments for Alzheimer’s disease (AD) only providing temporary symptomatic benefits, disease modifying drugs are urgently required. This approach relies on improved understanding of the early pathophysiology of AD.
Akkerman, Bouter, Brady, Brouillette, Chen, Cheng, Cohen, Daniels, Desbene, Domek-Lopacinska, Figueiredo, Garcia, Garcia-Osta, Gong, Goutagny, Grayson, Grayson, Griffin, Harte, Jarosz-Griffiths, Lacor, Lai, Lesné, Martinez, Matsumura, McKibben, McLean, McLean, McLean, Ono, Paxinos, Rosales-Corral, Satoh, Selkoe, Shaftel, Shankar, Snigdha, Sohal, Taguchi, Townsend, Verret, Wang, Warburton, Youssef   +43 more
core   +2 more sources

Therapy for X-adrenoleukodystrophy: normalization of very long chain fatty acids and inhibition of induction of cytokines by cAMP

Journal of Lipid Research, 1998
X-adrenoleukodystrophy (X-ALD) is an inherited fatty acid metabolic disorder with secondary manifestation of neuroinflammatory disease process. We report that compounds (forskolin, 8-bromo cAMP, and rolipram) that increase cAMP and activate protein ...
Kalipada Pahan, Mushfiquddin Khan, Inderjit Singh   +2 more
doaj  

Changes in the expression of extracellular regulated kinase (ERK 1/2) in the R6/2 mouse model of Huntington's disease after phosphodiesterase IV inhibition

Neurobiology of Disease, 2012
The mitogen-activated protein kinases (MAPKs) superfamily comprises three major signaling pathways: the extracellular signal-regulated protein kinases (ERKs), the c-Jun N-terminal kinases or stress-activated protein kinases (JNKs/SAPKs) and the p38 ...
Francesca R. Fusco, Serenella Anzilotti, Carmela Giampà, Clemente Dato, Daunia Laurenti, Alessandro Leuti, Luca Colucci D'Amato, Lorena Perrone, Giorgio Bernardi, Mariarosa A.B. Melone   +9 more
doaj  

The role of cyclic nucleotide phosphodiesterases in the regulation of adipocyte lipolysis

Journal of Lipid Research, 2005
This study assessed the effects of selective inhibitors of 3′,5′-cyclic nucleotide phosphodiesterases (PDEs) on adipocyte lipolysis. IC224, a selective inhibitor of type 1 phosphodiesterase (PDE1), suppressed lipolysis in murine 3T3-L1 adipocytes (69.6 ±
Peter B. Snyder, James M. Esselstyn, Kate Loughney, Sharon L. Wolda, Vincent A. Florio   +4 more
doaj  

Glucose Derivatives as Efficient Markers of Cell Reversible Electropermeabilization [PDF]

, 2016
— Molecules spontaneously transported inside the cells, like glucose derivatives, can also be used as electropermeabilization markers. In a previous study, we evaluated the uptake of a fluorescent deoxyglucose derivative (2-NBDG) by normal and ...
Lemoigne, Y., Mir, LM., Raeisi, E.
core  

Rolipram Inhibits Staphylococcal Enterotoxin B-Mediated Induction of the Human Skin-Homing Receptor on T Lymphocytes [PDF]

, 1999
Luis F. Santamaria‐Babí, Rosa Torres, Hamish Ryder, J.M. Palacios, Jörge Beleta, Ana M. Giménez‐Arnau, J.M. Gimenez-Camarasa   +6 more
openalex   +1 more source

Inhibition of pulmonary eosinophilia and airway hyperresponsiveness in allergic mice by rolipram: involvement of endogenously released corticosterone and catecholamines [PDF]

, 2000
T T Kung, Yvette Crawley, Bin Luo, Simon Young, William Kreutner, Richard W. Chapman   +5 more
openalex   +1 more source