Results 161 to 170 of about 4,908 (210)

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Rolipram attenuates bleomycin A5‐induced pulmonary fibrosis in rats

Respirology, 2009
ABSTRACTBackground and objective: Pulmonary fibrosis has a poor prognosis. The pathogenesis of fibrotic disorders is unclear, but the extent of lung damage due to persistent inflammation is regarded as a critical factor. Rolipram inhibits inflammation induced by various stimuli, as well as the chemotaxis of fibroblasts.
Yu Hong Hou, Guojun Zhang, Jin Bing Pan
exaly   +3 more sources

Pharmacokinetics of (+)-rolipram and (?)-rolipram in healthy volunteers

European Journal of Clinical Pharmacology, 1990
Plasma levels of S-(+)-rolipram and R-(-)-rolipram in six healthy male volunteers were measured by radioimmunoassay after intravenous injection of 0.1 mg and oral administration of 1.0 mg of the pure enantiomers. Following i.v. treatment, plasma levels of both isomers declined in three phases, with half-lives of 0.2 h, 0.6-0.9 h and 6-8 h.
W. Krause, G. Kühne, N. Sauerbrey
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Synthesis of (±)-Rolipram

HETEROCYCLES, 2003
AbstractFor Abstract see ChemInform Abstract in Full Text.
Shui-Tein Chen, Meng-Yang Chang, Pei-Pei Sun, Nein-Chen Chang   +3 more
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Efficient synthesis of (−)-(R)- and (+)-(S)-rolipram

Tetrahedron Letters, 2017
Abstract A novel, efficient and protecting group free enantioselective synthetic approach of (−)-( R )- 1 and (+)-( S )-rolipram 2 is described employing the organocatalyzed asymmetric Michael addition, Henry condensation, Wittig olefination and reductive lactamization reactions as key steps.
Satyendra Kumar Pandey, Ramandeep Kaur
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Pharmacokinetics of the Antidepressant Rolipram in Healthy Volunteers

Xenobiotica, 1989
1. The pharmacokinetics of rolipram were studied in healthy male volunteers using 3H-rolipram and a radioimmunoassay for measurement of unchanged drug. 2. Rolipram was rapidly and completely absorbed after an oral dose of 1 mg. Bioavailability was 73%. 3. Plasma levels of the unchanged drug declined with a terminal half-life of 2 h. The total clearance
W. Krause, H. Matthes, G Kühne
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Kinetics of (R)-[11C] rolipram and (S)-[11C] rolipram In the Dog Heart: Investigation of Four Compartment Models

2006 IEEE Nuclear Science Symposium Conference Record, 2006
The PET tracers (R)-[11C] rolipram and (S)-[11C] rolipram have been proposed to measure phosphodiesterase-4 (PDE4) density as an indirect index of cAMP-mediated cell signaling, which is altered in many cardiac pathologies. The aim of this study was to determine which of the following models (if any) describe the kinetics of these tracers in normal dog ...
R.S. Beanlands, R.A. deKemp, J. DaSilva, M. Lortie, Miran Kenk, S. Thorn   +5 more
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Effects of rolipram on in vivo dopamine receptor binding [PDF]

Journal of Neural Transmission, 2002
In order to clarify whether changes in brain concentrations of the second messenger cyclic AMP (cAMP) affect in vivo receptor binding in the brain, the effects of rolipram, a selective inhibitor of phosphodiesterase type 4 (PDE(4)), on dopamine receptor binding in the mouse brain were studied.
Hosoi, R, Ishikawa, M, Kobayashi, K, Gee, A, Yamaguchi, M, Inoue, O, Gee, Tony   +6 more
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Rolipram inhibition of phosphodiesterase-4 activation

European Journal of Pharmacology: Molecular Pharmacology, 1995
Rolipram inhibited U937 cell phosphodiesterase-4 in either the presence or absence of saturating (100 micrograms/ml) phosphatidic acid in an apparently phospholipid-independent manner, exhibiting similar kinetics (Ki values = 0.41 and 0.59 microM, respectively).
Richard J. Heaslip, Michael E. DiSanto
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