Results 171 to 180 of about 4,908 (210)
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In-patient major depression: is rolipram as effective as amitriptyline?
European Journal of Clinical Pharmacology, 1991The antidepressant efficacy and adverse-effects of rolipram (a dialkoxyphenyl-2-pyrrolidone) were compared to those of amitriptyline in the treatment of depressive illness requiring hospital admission in a double-blind study. Fifty patients meeting DSM-III criteria for Major Depression whose scores on the Hamilton Rating Scale for Depression (HRSD ...
Lawrence J. Whalley +3 more
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Rolipram reduces excitotoxic neuronal damage
Neuroreport, 2001Proinflammatory cytokines are supposed to be involved in the pathophysiology of neuronal damage following excitotoxic lesions. We examined the effect of rolipram, a TNF-alpha-inhibitor, on excitotoxic neuronal damage. Quinolinic acid (240 nmol in 1 microl) was injected stereotactically into the striatum of male Wistar rats.
W. Schmidt +3 more
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The Influence of Rolipram on the Central Serotoninergic System
Pharmacopsychiatry, 1981The influence of rolipram, a potential psychotropic drug, on the central serotoninergic system was studied. Rolipram was found to elicit the head twitch reaction in rats but not in mice. This effect was abolished by phenoxybenzamine, clonidine and morphine but not by cyproheptadine, metergoline and pizotifen.
A Lewandowska +2 more
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2012 International Conference on Biomedical Engineering and Biotechnology, 2012
In this study we explored that whether PDE inhibitor rolipram affected cholesrterol efflux and ABCA1 expression in THP-1 macrophage foam cells. Cholesterol efflux in THP-1 macrophage-derived foam cells were detected by FJ-2107P type liquid scintillator. The expression of ABCA1 mRNA and protein were determined by RT-PCR and Western blotting respectively.
Kai Yin +8 more
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In this study we explored that whether PDE inhibitor rolipram affected cholesrterol efflux and ABCA1 expression in THP-1 macrophage foam cells. Cholesterol efflux in THP-1 macrophage-derived foam cells were detected by FJ-2107P type liquid scintillator. The expression of ABCA1 mRNA and protein were determined by RT-PCR and Western blotting respectively.
Kai Yin +8 more
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Modulation of corneal endothelial hydration control mechanisms by Rolipram
Pflügers Archiv - European Journal of Physiology, 2000Corneal stromal hydration is maintained by an active HCO3- transport mechanism located in the corneal endothelium. Whilst modulation of transport activity by changes in intracellular cAMP concentration have been noted, the site of effect is undefined. To resolve this question, the effects of Rolipram, a cAMP phosphodiesterase inhibitor, on endothelial ...
Stuart Hodson +3 more
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Lymphocyte Suppression by Rolipram with Other Immunosuppressive Drugs
The Journal of Clinical Pharmacology, 1999Pentoxifylline, a nonselective phosphodiesterase inhibitor, has immunomodulatory activity in vitro and in vivo and potentiates the suppressive effects of glucocorticoids and cyclosporine on lymphocyte proliferation in vitro. Since phosphodiesterase isotypes 3 and 4 predominate in lymphocytes, the authors measured the suppressive effect of rolipram ...
Michael J. Choi +5 more
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Stereospecific binding of the antidepressant rolipram to brain protein structures
European Journal of Pharmacology, 1986The characteristics for the binding of the selective cAMP phosphodiesterase inhibitor and antidepressant agent rolipram to brain and peripheral organs were investigated. (+/-)-[3H]Rolipram equilibrium binding and Scatchard analysis revealed saturable, reversible, stereospecific, Mg2+-dependent and heat-sensitive binding with an apparent Hill number of ...
Herbert Schneider +3 more
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ChemInform Abstract: Synthesis of the Novel Antidepressant (R)‐(‐)‐Rolipram.
ChemInform, 1997AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Haishan Wang, Nicole Langlois
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Prevention by rolipram of concanavalin A-induced T-cell-dependent hepatitis in mice
European Journal of Pharmacology, 1999Rolipram is a type IV phosphodiesterase inhibitor endowed with powerful immunomodulatory properties. In this study, we evaluated the effects of this drug on the development of the T-cell-mediated hepatitis inducible in mice by concanavalin A. The results indicated that prophylactic treatment with either 5 or 10 mg/kg rolipram injected intraperitoneally
Xiang M +7 more
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Design of rolipram-loaded nanoparticles: comparison of two preparation methods
Journal of Controlled Release, 2001The aim of the present work was to investigate the preparation of nanoparticles as a potential drug carrier and targeting system for the treatment of inflammatory bowel disease. Rolipram was chosen as the model drug to be incorporated within nanoparticles.
Alf Lamprecht +7 more
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