Results 181 to 190 of about 7,547 (235)

Rolipram rescues memory consolidation deficits caused by sleep deprivation: Implication of the cAMP/PKA and cAMP/Epac pathways.

CNS and Neurological Disorders - Drug Targets, 2021
BACKGROUND Over the last few years, the number of people suffering from sleeping disorders has increased significantly despite negative effects on cognition and an association with brain inflammation.
A. Maher, Nesrine S. El Sayed, Heba Nafea, M. Gad   +3 more
semanticscholar   +1 more source

Synthesis of (±)-Rolipram

HETEROCYCLES, 2003
AbstractFor Abstract see ChemInform Abstract in Full Text.
Meng‐Yang Chang, Pei‐Pei Sun, Shui‐Tein Chen, Nein‐Chen Chang   +3 more
openaire   +1 more source

Pharmacokinetics of (+)-rolipram and (?)-rolipram in healthy volunteers

European Journal of Clinical Pharmacology, 1990
Plasma levels of S-(+)-rolipram and R-(-)-rolipram in six healthy male volunteers were measured by radioimmunoassay after intravenous injection of 0.1 mg and oral administration of 1.0 mg of the pure enantiomers. Following i.v. treatment, plasma levels of both isomers declined in three phases, with half-lives of 0.2 h, 0.6-0.9 h and 6-8 h.
W, Krause, G, Kühne, N, Sauerbrey
openaire   +2 more sources

Vesicle-Encapsulated Rolipram (PDE4 Inhibitor) and Its Anticancer Activity

ACS Applied Bio Materials, 2023
Vesicular carriers of drugs are popular for specific targeting and delivery. The most popular vesicles among these are liposomes. However, they suffer from some inherent limitations. In this work, alternative vesicles with enhanced stability, i.e., niosomes and bilosomes have been prepared, characterized, and their delivery efficiency studied ...
Durga Mondal, Arka Bagchi, Sima Biswas, Tanmay Dagar, Arunima Biswas, Angshuman Bagchi, Swati De   +6 more
openaire   +2 more sources

Rolipram reduces excitotoxic neuronal damage

Neuroreport, 2001
Proinflammatory cytokines are supposed to be involved in the pathophysiology of neuronal damage following excitotoxic lesions. We examined the effect of rolipram, a TNF-alpha-inhibitor, on excitotoxic neuronal damage. Quinolinic acid (240 nmol in 1 microl) was injected stereotactically into the striatum of male Wistar rats.
F, Block, W, Schmidt, M, Nolden-Koch, M, Schwarz   +3 more
openaire   +2 more sources

Rolipram inhibition of phosphodiesterase-4 activation

European Journal of Pharmacology: Molecular Pharmacology, 1995
Rolipram inhibited U937 cell phosphodiesterase-4 in either the presence or absence of saturating (100 micrograms/ml) phosphatidic acid in an apparently phospholipid-independent manner, exhibiting similar kinetics (Ki values = 0.41 and 0.59 microM, respectively).
M E, DiSanto, R J, Heaslip
openaire   +2 more sources

PDE Inhibitor Rolipram Increases Cholesterol Efflux and ABCA1 Expression: Rolipram Increases ABCA1 Expression

2012 International Conference on Biomedical Engineering and Biotechnology, 2012
In this study we explored that whether PDE inhibitor rolipram affected cholesrterol efflux and ABCA1 expression in THP-1 macrophage foam cells. Cholesterol efflux in THP-1 macrophage-derived foam cells were detected by FJ-2107P type liquid scintillator. The expression of ABCA1 mRNA and protein were determined by RT-PCR and Western blotting respectively.
Ping-Ping He, Xin-Ping OuYang, Kai Yin, Wu-Jun Chen, Qian Lu, Zhong-Cheng Mo, Guo-Jun Zhao, Yun-Cheng Lv, Chao-Ke Tang   +8 more
openaire   +1 more source

Lymphocyte Suppression by Rolipram with Other Immunosuppressive Drugs

The Journal of Clinical Pharmacology, 1999
Pentoxifylline, a nonselective phosphodiesterase inhibitor, has immunomodulatory activity in vitro and in vivo and potentiates the suppressive effects of glucocorticoids and cyclosporine on lymphocyte proliferation in vitro. Since phosphodiesterase isotypes 3 and 4 predominate in lymphocytes, the authors measured the suppressive effect of rolipram ...
W A, Briggs, Q, Wu, O, Orgul, M, Choi, P J, Scheel, J, Burdick   +5 more
openaire   +2 more sources

Pharmacokinetics of the Antidepressant Rolipram in Healthy Volunteers

Xenobiotica, 1989
1. The pharmacokinetics of rolipram were studied in healthy male volunteers using 3H-rolipram and a radioimmunoassay for measurement of unchanged drug. 2. Rolipram was rapidly and completely absorbed after an oral dose of 1 mg. Bioavailability was 73%. 3. Plasma levels of the unchanged drug declined with a terminal half-life of 2 h. The total clearance
W, Krause, G, Kühne, H, Matthes
openaire   +2 more sources

Modulation of corneal endothelial hydration control mechanisms by Rolipram

Pflügers Archiv - European Journal of Physiology, 2000
Corneal stromal hydration is maintained by an active HCO3- transport mechanism located in the corneal endothelium. Whilst modulation of transport activity by changes in intracellular cAMP concentration have been noted, the site of effect is undefined. To resolve this question, the effects of Rolipram, a cAMP phosphodiesterase inhibitor, on endothelial ...
C G, Wigham, H C, Turner, J, Swan, S A, Hodson   +3 more
openaire   +2 more sources