Cyclic AMP signaling promotes regeneration of cochlear synapses after excitotoxic or noise trauma [PDF]
Frontiers in Cellular NeuroscienceIntroductionCochlear afferent synapses connecting inner hair cells to spiral ganglion neurons are susceptible to excitotoxic trauma on exposure to loud sound, resulting in a noise-induced cochlear synaptopathy (NICS).
Sriram Hemachandran +3 more
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Attenuation of MPTP neurotoxicity by rolipram, a specific inhibitor of phosphodiesterase IV [PDF]
Experimental Neurology, 2008 Rolipram, a specific inhibitor of the phosphodiesterase IV (PDE IV), has recently been shown to exert neuroprotective effects in an Alzheimer transgenic mouse model and in hypoxic-ischemic damage in the rat brain. It activates the cAMP-dependent protein kinase (PKA)/cAMP regulatory element-binding protein (CREB) signaling pathway and it inhibits ...
Lichuan Yang +3 more
openaire +4 more sources
Rolipram as a Discriminative Stimuli: Transfer to Phosphodiesterase Inhibitors
Japanese Journal of Pharmacology, 1987 Rats were trained to discriminate (+/-)-rolipram (0.32 mg/kg, i.p.) from saline in a two-lever food-reinforced drug discrimination procedure (FR 10). (+/-)-Rolipram served as a drug discriminative stimulus, and its discrimination was readily established with a mean of 42 training sessions to achieve criterion performance (at least 80% correct response ...
Kazuyo Miyamoto +2 more
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Beneficial effects of rolipram in a quinolinic acid model of striatal excitotoxicity
Neurobiology of Disease, 2007 Activity of c-AMP responsive element-binding protein (CREB) is decreased in Huntington’s disease (HD). Such decrease was also described by our group in the quinolinic acid lesion model of striatal excitotoxicity.
Zena DeMarch +5 more
doaj +5 more sources
Inhibition of PDE‐4 isoenzyme attenuates frequency and overall contractility of agonist‐evoked ureteral phasic contractions [PDF]
Pharmacology Research & PerspectivesThe aim of this study was to investigate the functional role of phosphodiesterase enzymes (PDE) in the isolated porcine ureter. Distal ureteral strips were mounted in organ baths and pre‐contracted with 5‐HT (100 μM).
Iris Lim +4 more
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Frontiers in Aging Neuroscience, 2015 AimSystemic pharmacotherapies have limitation due to blood-labyrinth barrier, so local delivery via the round window membrane opens a path for effective treatment.
Rudolf Glueckert +2 more
exaly +3 more sources
Beneficial effects of rolipram in the R6/2 mouse model of Huntington's disease
Neurobiology of Disease, 2008 We have previously showed that rolipram, a phosphodiesterase type IV inhibitor, displays a neuroprotective effect in a rat quinolinic acid model of HD [DeMarch Z., Giampa C., Patassini S., Martorana A., Bernardi G.
Zena DeMarch +4 more
exaly +2 more sources
PDE4 inhibitor rolipram represses hedgehog signaling via ubiquitin-mediated proteolysis of GLI transcription factors to regress breast cancer. [PDF]
J Biol ChemBagchi A +5 more
europepmc +2 more sources
A functional aged human iPSC-cortical neuron model recapitulates Alzheimer's disease, senescence, and the response to therapeutics. [PDF]
Alzheimers DementAbstract INTRODUCTION The degeneration of cortical layers is associated with cognitive decline in Alzheimer's disease (AD). Current therapies for AD are not disease‐modifying, and, despite substantial efforts, research and development for AD has faced formidable challenges.
Gallo LH +10 more
europepmc +2 more sources
The therapeutic profile of rolipram, PDE target and mechanism of action as a neuroprotectant following spinal cord injury. [PDF]
PLoS ONE, 2012 The extent of damage following spinal cord injury (SCI) can be reduced by various neuroprotective regimens that include maintaining levels of cyclic adenosine monophosphate (cyclic AMP), via administration of the phosphodiesterase 4 (PDE4) inhibitor ...
Sandra Marie Schaal +10 more
doaj +1 more source