Results 11 to 20 of about 7,547 (235)
Basic and Clinical Neuroscience, 2017 Introduction: The mechanism of putative cytotoxicity of 4-[3-(cyclopentyloxy)-4-methoxyphenyl]-2-pyrrolidone (rolipram), a specific phosphodiesterase-4 (PDE4) inhibitor, on glioblastoma multiforme (GBM) is almost unknown.
Sara Ramezani +6 more
doaj +2 more sources
Mediators of Inflammation, 2016 Exposure to bacterial lipopolysaccharides (LPS) induces inflammatory signals in salivary glands. We investigated the regulatory role of phosphodiesterase 4 (PDE4) inhibitor rolipram on inflammatory mediators and cholinergic/adrenergic stimulation-induced
Dong Un Lee +2 more
doaj +2 more sources
Frontiers in Pharmacology, 2017 Chemotherapy-induced neuropathic pain is a significant side effect of chemotherapeutic agents and is the most common reason for stopping chemotherapy. The aim of the present study was to find the major site and mechanisms of action by which rolipram, a ...
Hee Kee Kim +3 more
doaj +2 more sources
Enantiodivergent Synthesis of (R)- and (S)-Rolipram [PDF]
Molecules, 1998 Both enantiomers of rolipram (1) have been prepared in large quantity from a common intermediate rac-3-(3’-cyclopentyloxy-4’-methoxy)phenyl-4-nitro butyric acid (6), which was resolved by way of the two readily separable diastereoisomeric ...
Esteban Pombo-Villar +7 more
doaj +2 more sources
A Nonhuman Primate PET Study: Measurement of Brain PDE4 Occupancy by Roflumilast Using (R)-[11C]Rolipram [PDF]
Molecular Imaging and Biology, 2018 PurposePhosphodiesterase 4 (PDE4) inhibition in the brain has been reported to improve cognitive function in animal models. Therefore, PDE4 inhibitors are one of key targets potential for drug development. Investigation of brain PDE4 occupancy would help
Akihiro Takano +8 more
openalex +2 more sources
Rolipram Improves Outcome in a Rat Model of Infant Sepsis-Induced Cardiorenal Syndrome
Frontiers in Pharmacology, 2017 While the mortality rate associated with sepsis in children has fallen over the years, it still remains unacceptably high. The development of both acute cardiac dysfunction and acute kidney injury during severe sepsis is categorized as type 5 cardiorenal
Clark R. Sims +6 more
doaj +2 more sources
Phosphodiesterase type 4 inhibitor rolipram improves survival of spiral ganglion neurons in vitro. [PDF]
PLoS ONE, 2014 Sensorineural deafness is caused by damage of hair cells followed by degeneration of the spiral ganglion neurons and can be moderated by cochlear implants.
Katharina Kranz +4 more
doaj +2 more sources
Caffeine and rolipram affect Smad signalling and TGF-β1 stimulated CTGF and transgelin expression in lung epithelial cells. [PDF]
PLoS ONE, 2014 Caffeine administration is an important part of the therapeutic treatment of bronchopulmonary dysplasia (BPD) in preterm infants. However, caffeine mediated effects on airway remodelling are still undefined.
Markus Fehrholz +2 more
doaj +2 more sources
Drug Target Insights, 2014 The role of phosphodiesterase (PDE) inhibitors in central nervous system has been investigated and shown to stimulate neuronal functions and increase neurogenesis in Alzheimer patients.
Furuzan Akar +7 more
doaj +2 more sources
Frontiers in Aging Neuroscience, 2015 AimSystemic pharmacotherapies have limitation due to blood-labyrinth barrier, so local delivery via the round window membrane opens a path for effective treatment.
Rudolf eGlueckert +6 more
doaj +2 more sources