Results 191 to 200 of about 7,547 (235)

Kinetics of (R)-[11C] rolipram and (S)-[11C] rolipram In the Dog Heart: Investigation of Four Compartment Models

2006 IEEE Nuclear Science Symposium Conference Record, 2006
The PET tracers (R)-[11C] rolipram and (S)-[11C] rolipram have been proposed to measure phosphodiesterase-4 (PDE4) density as an indirect index of cAMP-mediated cell signaling, which is altered in many cardiac pathologies. The aim of this study was to determine which of the following models (if any) describe the kinetics of these tracers in normal dog ...
Mireille Lortie, Jean DaSilva, Miran Kenk, Stephanie Thorn, Rob Beanlands, Robert deKemp   +5 more
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Efficient synthesis of (−)-(R)- and (+)-(S)-rolipram

Tetrahedron Letters, 2017
Abstract A novel, efficient and protecting group free enantioselective synthetic approach of (−)-( R )- 1 and (+)-( S )-rolipram 2 is described employing the organocatalyzed asymmetric Michael addition, Henry condensation, Wittig olefination and reductive lactamization reactions as key steps.
Ramandeep Kaur, Satyendra Kumar Pandey
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Rolipram attenuates bleomycin A5‐induced pulmonary fibrosis in rats

Respirology, 2009
ABSTRACTBackground and objective: Pulmonary fibrosis has a poor prognosis. The pathogenesis of fibrotic disorders is unclear, but the extent of lung damage due to persistent inflammation is regarded as a critical factor. Rolipram inhibits inflammation induced by various stimuli, as well as the chemotaxis of fibroblasts.
Jin Bing, Pan, Yu Hong, Hou, Guo Jun, Zhang   +2 more
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Rolipram Attenuates MK-801-Induced Deficits in Latent Inhibition.

Behavioral Neuroscience, 2005
Latent inhibition is used to examine attention and study cognitive deficits associated with schizophrenia. Research using MK-801, an N-methyl-D-aspartate (NMDA) open channel blocker, implicates glutamate receptors in acquisition of latent inhibition of cued fear conditioning. Evidence suggests an important relationship between NMDA-induced increases in
Jennifer A, Davis, Thomas J, Gould
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Effects of rolipram on in vivo dopamine receptor binding

Journal of Neural Transmission, 2002
In order to clarify whether changes in brain concentrations of the second messenger cyclic AMP (cAMP) affect in vivo receptor binding in the brain, the effects of rolipram, a selective inhibitor of phosphodiesterase type 4 (PDE(4)), on dopamine receptor binding in the mouse brain were studied.
Hosoi, R, Ishikawa, M, Kobayashi, K, Gee, A, Yamaguchi, M, Inoue, O, Gee, Tony   +6 more
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Design of rolipram-loaded nanoparticles: comparison of two preparation methods

Journal of Controlled Release, 2001
The aim of the present work was to investigate the preparation of nanoparticles as a potential drug carrier and targeting system for the treatment of inflammatory bowel disease. Rolipram was chosen as the model drug to be incorporated within nanoparticles.
A, Lamprecht, N, Ubrich, H, Yamamoto, U, Schäfer, H, Takeuchi, C M, Lehr, P, Maincent, Y, Kawashima   +7 more
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The Influence of Rolipram on the Central Serotoninergic System

Pharmacopsychiatry, 1981
The influence of rolipram, a potential psychotropic drug, on the central serotoninergic system was studied. Rolipram was found to elicit the head twitch reaction in rats but not in mice. This effect was abolished by phenoxybenzamine, clonidine and morphine but not by cyproheptadine, metergoline and pizotifen.
E, Przegalínski, K, Bigajska, A, Lewandowska   +2 more
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Stereospecific binding of the antidepressant rolipram to brain protein structures

European Journal of Pharmacology, 1986
The characteristics for the binding of the selective cAMP phosphodiesterase inhibitor and antidepressant agent rolipram to brain and peripheral organs were investigated. (+/-)-[3H]Rolipram equilibrium binding and Scatchard analysis revealed saturable, reversible, stereospecific, Mg2+-dependent and heat-sensitive binding with an apparent Hill number of ...
H H, Schneider, R, Schmiechen, M, Brezinski, J, Seidler   +3 more
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Asymmetric synthesis of the Novel Antidepressant Rolipram�

Journal f�r Praktische Chemie/Chemiker-Zeitung, 1994
To illustrate the flexibility of modern asymmetric synthesis six alternative routes are presented for the preparation of the novel antidepressant Rolipram®. The routes are based on optical resolution, on the concept of “ex-chiral pool synthesis” with lactic or tartaric acid as the starting materials, and on the application of chiral auxiliaries.
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Enantioselektive Synthese des Antidepressivums Rolipram durch Nitroolefin‐Michael‐Addition

Angewandte Chemie, 1992
In nur vier Stufen lassen sich beide Enantiomere des Antidepressivums Rolipram 3 herstellen. Schlüsselschritt der hoch enantioselektiven Synthese ist die Michael‐Addition des Nitroolefins 1 an das Evans‐Enolat 2.
Johann Mulzer, Ralf Zuhse, Ralph Schmiechen   +2 more
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