Results 221 to 230 of about 11,777 (278)

Rolipram rescues memory consolidation deficits caused by sleep deprivation: Implication of the cAMP/PKA and cAMP/Epac pathways.

CNS and Neurological Disorders - Drug Targets, 2021
BACKGROUND Over the last few years, the number of people suffering from sleeping disorders has increased significantly despite negative effects on cognition and an association with brain inflammation.
A. Maher, Nesrine S. El Sayed, H. Nafea, M. Gad   +3 more
semanticscholar   +1 more source

Pharmacokinetics of (+)-rolipram and (?)-rolipram in healthy volunteers

European Journal of Clinical Pharmacology, 1990
Plasma levels of S-(+)-rolipram and R-(-)-rolipram in six healthy male volunteers were measured by radioimmunoassay after intravenous injection of 0.1 mg and oral administration of 1.0 mg of the pure enantiomers. Following i.v. treatment, plasma levels of both isomers declined in three phases, with half-lives of 0.2 h, 0.6-0.9 h and 6-8 h.
W. Krause, G. Kühne, N. Sauerbrey
openaire   +3 more sources

Synthesis of (±)-Rolipram

HETEROCYCLES, 2003
AbstractFor Abstract see ChemInform Abstract in Full Text.
Shui-Tein Chen, Meng-Yang Chang, Pei-Pei Sun, Nein-Chen Chang   +3 more
openaire   +3 more sources

Efficient synthesis of (−)-(R)- and (+)-(S)-rolipram

Tetrahedron Letters, 2017
Abstract A novel, efficient and protecting group free enantioselective synthetic approach of (−)-( R )- 1 and (+)-( S )-rolipram 2 is described employing the organocatalyzed asymmetric Michael addition, Henry condensation, Wittig olefination and reductive lactamization reactions as key steps.
Satyendra Kumar Pandey, Ramandeep Kaur
openaire   +2 more sources

Pharmacokinetics of the Antidepressant Rolipram in Healthy Volunteers

Xenobiotica, 1989
1. The pharmacokinetics of rolipram were studied in healthy male volunteers using 3H-rolipram and a radioimmunoassay for measurement of unchanged drug. 2. Rolipram was rapidly and completely absorbed after an oral dose of 1 mg. Bioavailability was 73%. 3. Plasma levels of the unchanged drug declined with a terminal half-life of 2 h. The total clearance
W. Krause, H. Matthes, G Kühne
openaire   +3 more sources

Effects of rolipram on in vivo dopamine receptor binding [PDF]

Journal of Neural Transmission, 2002
In order to clarify whether changes in brain concentrations of the second messenger cyclic AMP (cAMP) affect in vivo receptor binding in the brain, the effects of rolipram, a selective inhibitor of phosphodiesterase type 4 (PDE(4)), on dopamine receptor binding in the mouse brain were studied.
Hosoi, R, Ishikawa, M, Kobayashi, K, Gee, A, Yamaguchi, M, Inoue, O, Gee, Tony   +6 more
openaire   +3 more sources

Kinetics of (R)-[11C] rolipram and (S)-[11C] rolipram In the Dog Heart: Investigation of Four Compartment Models

2006 IEEE Nuclear Science Symposium Conference Record, 2006
The PET tracers (R)-[11C] rolipram and (S)-[11C] rolipram have been proposed to measure phosphodiesterase-4 (PDE4) density as an indirect index of cAMP-mediated cell signaling, which is altered in many cardiac pathologies. The aim of this study was to determine which of the following models (if any) describe the kinetics of these tracers in normal dog ...
R.S. Beanlands, R.A. deKemp, J. DaSilva, M. Lortie, Miran Kenk, S. Thorn   +5 more
openaire   +2 more sources

In-patient major depression: is rolipram as effective as amitriptyline?

European Journal of Clinical Pharmacology, 1991
The antidepressant efficacy and adverse-effects of rolipram (a dialkoxyphenyl-2-pyrrolidone) were compared to those of amitriptyline in the treatment of depressive illness requiring hospital admission in a double-blind study. Fifty patients meeting DSM-III criteria for Major Depression whose scores on the Hamilton Rating Scale for Depression (HRSD ...
Lawrence J. Whalley, A. F. Perini, P. A. Shering, Allan I. F. Scott   +3 more
openaire   +3 more sources

Rolipram inhibition of phosphodiesterase-4 activation

European Journal of Pharmacology: Molecular Pharmacology, 1995
Rolipram inhibited U937 cell phosphodiesterase-4 in either the presence or absence of saturating (100 micrograms/ml) phosphatidic acid in an apparently phospholipid-independent manner, exhibiting similar kinetics (Ki values = 0.41 and 0.59 microM, respectively).
Richard J. Heaslip, Michael E. DiSanto
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Rolipram reduces excitotoxic neuronal damage

Neuroreport, 2001
Proinflammatory cytokines are supposed to be involved in the pathophysiology of neuronal damage following excitotoxic lesions. We examined the effect of rolipram, a TNF-alpha-inhibitor, on excitotoxic neuronal damage. Quinolinic acid (240 nmol in 1 microl) was injected stereotactically into the striatum of male Wistar rats.
W. Schmidt, M. Nolden-Koch, Michael Schwarz, Frank Block   +3 more
openaire   +3 more sources