Results 21 to 30 of about 4,842 (209)

Structure and regulation of desmosomes in intercalated discs: Lessons from epithelia

Journal of Anatomy, Volume 242, Issue 1, Page 81-90, January 2023., 2023
Adrenergic agonists act via PKA‐dependent PG phosphorylation at S665, leading to enhanced translocation of DSG2 to the desmosomes or area composita of the ICD and thereby increasing cardiomyocyte adhesion. On the other hand adrenergic agonists, PKC activation by PMA ,p38MAPK inhibition by SB202190 and digitoxin enhanced cardiomyocyte adhesion, in an ...
Sunil Yeruva, Jens Waschke
wiley   +1 more source

Inhibition of phosphodiesterases 1 and 4 prevents myofibroblast transformation in Peyronie's disease. [PDF]

BJU Int
Objectives To investigate which phosphodiesterase (PDE) isoforms are expressed in fibroblasts isolated from the tunica albuginea (TA) of patients with Peyronie's disease (PD), and to measure the potency of PDE inhibitors in preventing transformation of these fibroblasts to profibrotic myofibroblasts.
Harding SL, Ilg MM, Bustin SA, Ralph DJ, Cellek S.   +4 more
europepmc   +2 more sources

Effects of phosphodiesterase 4 inhibition on alveolarization and hyperoxia toxicity in newborn rats. [PDF]

PLoS ONE, 2008
BACKGROUND: Prolonged neonatal exposure to hyperoxia is associated with high mortality, leukocyte influx in airspaces, and impaired alveolarization.
Céline Méhats, Marie-Laure Franco-Montoya, Olivier Boucherat, Emmanuel Lopez, Thomas Schmitz, Elodie Zana, Danièle Evain-Brion, Jacques Bourbon, Christophe Delacourt, Pierre-Henri Jarreau   +9 more
doaj   +1 more source

The therapeutic profile of rolipram, PDE target and mechanism of action as a neuroprotectant following spinal cord injury. [PDF]

PLoS ONE, 2012
The extent of damage following spinal cord injury (SCI) can be reduced by various neuroprotective regimens that include maintaining levels of cyclic adenosine monophosphate (cyclic AMP), via administration of the phosphodiesterase 4 (PDE4) inhibitor ...
Sandra Marie Schaal, Maneesh Sen Garg, Mousumi Ghosh, Lilie Lovera, Michael Lopez, Monal Patel, Jack Louro, Samik Patel, Luis Tuesta, Wai-Man Chan, Damien Daniel Pearse   +10 more
doaj   +1 more source

Rolipram Inhibits Polarization and Migration of Human T Lymphocytes [PDF]

Journal of Investigative Dermatology, 2003
Phosphodiesterase inhibitors possess anti-inflammatory and immunomodulatory properties and seem to have a great potential in the treatment of inflammatory skin diseases; however, an overall study on the effects of specific phosphodiesterase inhibitors, such as rolipram on the processes involved in the extravasation of lymphoid cells has not been ...
Lourdes Baranda, Brenda Alvarado-Sánchez, H. Portillo-Salazar, Esther Layseca-Espinosa, Diana P. Portales-Pérez, Roberto González-Amaro   +5 more
openaire   +3 more sources

Phosphodiesterase type 4 inhibitor rolipram improves survival of spiral ganglion neurons in vitro. [PDF]

PLoS ONE, 2014
Sensorineural deafness is caused by damage of hair cells followed by degeneration of the spiral ganglion neurons and can be moderated by cochlear implants.
Katharina Kranz, Athanasia Warnecke, Thomas Lenarz, Martin Durisin, Verena Scheper   +4 more
doaj   +1 more source

Synaptic proteasome is inhibited in Alzheimer’s disease models and associates with memory impairment in mice [PDF]

Alzheimers Dement
Abstract Background The proteasome plays key roles in synaptic plasticity and memory by regulating protein turnover, quality control, and elimination of oxidized/misfolded proteins. Here, we investigate proteasome function and localization at synapses in Alzheimer’s disease (AD) post‐mortem brain tissue and in experimental models.
Ribeiro F, Ferreira D, Heimfarth L, Fortuna J, de Freitas G, Souza J, Alves‐Leon S, Leite R, Suemoto C, Grinberg L, De Felice F, Lourenco M, Ferreira S.   +12 more
europepmc   +2 more sources

Protective effects of rolipram on endotoxic cardiac dysfunction via inhibition of the inflammatory response in cardiac fibroblasts

BMC Cardiovascular Disorders, 2020
Background Cardiac fibroblasts, regarded as the immunomodulatory hub of the heart, have been thought to play an important role during sepsis-induced cardiomyopathy (SIC).
Jingjing Ji, Zhifeng Liu, Xinxin Hong, Zheying Liu, Jinghua Gao, Jinghua Liu   +5 more
doaj   +1 more source

Existence of rolipram‐sensitive phosphodiesterase in rat megakaryocyte [PDF]

British Journal of Pharmacology, 1993
The effect of rolipram (ME3176) on ADP‐ and IP3‐induced repetitive IK(Ca) in rat megakaryocyte was investigated by use of the nystatin perforated patch and conventional whole‐cell patch‐clamp techniques. The ADP‐induced IK(Ca) was depressed by treatment with rolipram in a concentration‐dependent manner.
Hisayuki Uneyama, Norio Akaike, Yoshiro Yamashita, Kazuyoshi Kawa   +3 more
openaire   +3 more sources

Influence of Aging on Rolipram-Sensitive Phosphodiesterase Activity and (3H)Rolipram Binding in the Rat Brain.

Biological and Pharmaceutical Bulletin, 1996
To clarify the quantitative and qualitative changes in type IV phosphodiesterase (PDE IV) with aging, phosphodiesterase (PDE) activity and [3H]rolipram binding in the cytosolic fraction from the brains of young and aged rats were examined. In all areas of the aged (100-week-old) rat brain except for hippocampus, the PDE activity was decreased by about ...
Yasuyuki Nomura, Michihisa Tohda, Toshihiko Murayama, Shinsuke Nogiri   +3 more
openaire   +4 more sources