Results 21 to 30 of about 4,908 (210)
Effects of phosphodiesterase 4 inhibition on alveolarization and hyperoxia toxicity in newborn rats. [PDF]
PLoS ONE, 2008 BACKGROUND: Prolonged neonatal exposure to hyperoxia is associated with high mortality, leukocyte influx in airspaces, and impaired alveolarization.
Céline Méhats +9 more
doaj +1 more source
Rolipram Inhibits Polarization and Migration of Human T Lymphocytes [PDF]
Journal of Investigative Dermatology, 2003 Phosphodiesterase inhibitors possess anti-inflammatory and immunomodulatory properties and seem to have a great potential in the treatment of inflammatory skin diseases; however, an overall study on the effects of specific phosphodiesterase inhibitors, such as rolipram on the processes involved in the extravasation of lymphoid cells has not been ...
Lourdes Baranda +5 more
openaire +3 more sources
Phosphodiesterase type 4 inhibitor rolipram improves survival of spiral ganglion neurons in vitro. [PDF]
PLoS ONE, 2014 Sensorineural deafness is caused by damage of hair cells followed by degeneration of the spiral ganglion neurons and can be moderated by cochlear implants.
Katharina Kranz +4 more
doaj +1 more source
Inhibition of phosphodiesterases 1 and 4 prevents myofibroblast transformation in Peyronie's disease. [PDF]
BJU IntObjectives To investigate which phosphodiesterase (PDE) isoforms are expressed in fibroblasts isolated from the tunica albuginea (TA) of patients with Peyronie's disease (PD), and to measure the potency of PDE inhibitors in preventing transformation of these fibroblasts to profibrotic myofibroblasts.
Harding SL +4 more
europepmc +2 more sources
BMC Cardiovascular Disorders, 2020 Background Cardiac fibroblasts, regarded as the immunomodulatory hub of the heart, have been thought to play an important role during sepsis-induced cardiomyopathy (SIC).
Jingjing Ji +5 more
doaj +1 more source
Biological and Pharmaceutical Bulletin, 1996 To clarify the quantitative and qualitative changes in type IV phosphodiesterase (PDE IV) with aging, phosphodiesterase (PDE) activity and [3H]rolipram binding in the cytosolic fraction from the brains of young and aged rats were examined. In all areas of the aged (100-week-old) rat brain except for hippocampus, the PDE activity was decreased by about ...
Yasuyuki Nomura +3 more
openaire +4 more sources
Existence of rolipram‐sensitive phosphodiesterase in rat megakaryocyte [PDF]
British Journal of Pharmacology, 1993 The effect of rolipram (ME3176) on ADP‐ and IP3‐induced repetitive IK(Ca) in rat megakaryocyte was investigated by use of the nystatin perforated patch and conventional whole‐cell patch‐clamp techniques. The ADP‐induced IK(Ca) was depressed by treatment with rolipram in a concentration‐dependent manner.
Hisayuki Uneyama +3 more
openaire +3 more sources
Mediators of Inflammation, 2016 Exposure to bacterial lipopolysaccharides (LPS) induces inflammatory signals in salivary glands. We investigated the regulatory role of phosphodiesterase 4 (PDE4) inhibitor rolipram on inflammatory mediators and cholinergic/adrenergic stimulation-induced
Dong Un Lee +2 more
doaj +1 more source
Potential PDE4B inhibitors as promising candidates against SARS‐CoV‐2 infection
Biomolecular Concepts, 2023 Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is an RNA virus belonging to the coronavirus family responsible for coronavirus disease 2019 (COVID-19).
Giuzio Federica +10 more
doaj +1 more source
HIV-1 gp120 Impairs Spatial Memory Through Cyclic AMP Response Element-Binding Protein
Frontiers in Aging Neuroscience, 2022 HIV-associated neurocognitive disorders (HAND) remain an unsolved problem that persists despite using antiretroviral therapy. We have obtained data showing that HIV-gp120 protein contributes to neurodegeneration through metabolic reprogramming.
Jenny Shrestha +26 more
doaj +1 more source