Results 21 to 30 of about 7,547 (235)

Effect of phosphodiesterase inhibitors on medication-related osteonecrosis of the jaw in mice: a comparison of phosphodiesterase-4 and phosphodiesterase-5 inhibition [PDF]

Acta Odontologica Scandinavica
Objective: Medication-related osteonecrosis of the jaw lacks proven pharmacological prevention. We compared a phosphodiesterase-4 inhibitor rolipram and a phosphodiesterase-5 inhibitor sildenafil in a zoledronic acid– and dexamethasone–based mouse model ...
Yunus Baş, Olgun Topal, Gökhan Sadi, Esra Aslan, Halit Buğra Koca, Mehmet Bilgehan Pektaş   +5 more
doaj   +2 more sources

Cyclic AMP signaling promotes regeneration of cochlear synapses after excitotoxic or noise trauma [PDF]

Frontiers in Cellular Neuroscience
IntroductionCochlear afferent synapses connecting inner hair cells to spiral ganglion neurons are susceptible to excitotoxic trauma on exposure to loud sound, resulting in a noise-induced cochlear synaptopathy (NICS).
Sriram Hemachandran, Ning Hu, Catherine J. Kane, Steven H. Green   +3 more
doaj   +2 more sources

ChemInform Abstract: A Stereoselective Synthesis of (R)‐(‐)‐Rolipram from L‐Glutamic Acid. [PDF]

Synthesis, 1997
A stereoselective synthesis of (R)-(-)-rolipram from L-glutamic acid is described. The key step is a stereoselective Michael addition of an arylcuprate to a modified pyroglutamic derivative which acts as the template to induce the stereoselectivity. Facile manipulation of the enantiomerically pure Michael product afforded the expected therapeutic agent.
A. Díaz, Jorge G. Siro, José L. Carcia-Navio, Juan J. Vaquero, Julio Álvarez‐Buílla   +4 more
openalex   +4 more sources

Improving the Characteristics of Fruiting Bodies in Lentinus edodes: The Impact of Rolipram-Induced cAMP Modulation [PDF]

Metabolites
Background: Strains XG04 and XGT2 of Lentinus edodes (Berk.) Singer demonstrate a high degree of genomic similarity, with XGT2 representing a systematic selection of XG04 and exhibiting enhanced phenotypic traits.
Hongman Li, Fei Chen, Chong Xu, Yanhua Wang, Chunhai Deng, Qingguo Meng, Weiwei Zhu   +6 more
doaj   +2 more sources

Image-derived input function derived from a supervised clustering algorithm: methodology and validation in a clinical protocol using [11C](R)-rolipram.

PLoS ONE, 2014
Image-derived input function (IDIF) obtained by manually drawing carotid arteries (manual-IDIF) can be reliably used in [(11)C](R)-rolipram positron emission tomography (PET) scans.
Chul Hyoung Lyoo, Paolo Zanotti-Fregonara, Sami S Zoghbi, Jeih-San Liow, Rong Xu, Victor W Pike, Carlos A Zarate, Masahiro Fujita, Robert B Innis   +8 more
doaj   +2 more sources

Rolipram-Loaded PgP Nanotherapeutics via Intrathecal Administration Reduces Secondary Injury in a Rat Acute Moderate Contusion SCI Model. [PDF]

J Neurosci Res
The biodistribution of DiR‐PgP and the therapeutic efficacy of Rm‐PgP after intrathecal administration was investigated in a rat moderate thoracic contusion SCI model. Intrathecal administration of DiR‐PgP showed CNS‐specific retention without peripheral distribution.
Liao Z, Gao J, Khang MK, Webb K, Detloff MR, Lee JS.   +5 more
europepmc   +2 more sources

PDE4 inhibitor rolipram represses hedgehog signaling via ubiquitin-mediated proteolysis of GLI transcription factors to regress breast cancer. [PDF]

J Biol Chem
Bagchi A, Bhattacharya A, Bera A, Basak D, Chatterji U, Biswas A.   +5 more
europepmc   +3 more sources

Rolipram and pentoxifylline combination ameliorates experimental diabetic neuropathy through inhibition of oxidative stress and inflammatory pathways in the dorsal root ganglion neurons

Metabolic brain disease, 2022
Diabetic neuropathy (DN) is the most challenging microvascular complication of diabetes and there is no suitable treatment for it, so the development of new agents to relieve DN is urgently needed.
M. Dastgheib, S. V. Shetab-Boushehri, M. Baeeri, M. Gholami, Mohammad Yahya Karimi, A. Hosseini   +5 more
semanticscholar   +1 more source

ATP8B1 Deficiency Causes Phosphodiesterase 4-Mediated Glucagon Resistance and Impaired Gluconeogenesis in Mouse and Human Liver. [PDF]

Liver Int
ABSTRACT Background and Aims Deficiency of the phospholipid transporter ATP8B1 causes infantile‐onset progressive familial intrahepatic cholestasis type I (PFIC1). Pre‐transplant PFIC1 patients often present with mild dyslipidaemia. This raises the possibility that PFIC1 patients, besides cholestasis, may also experience defects in glucose and lipid ...
Chang JC, Panhuis WIH, Hsu SH, Duijst S, Ho-Mok KS, van der Heiden JF, Ying Z, Erdmann JI, Vogel GF, Junge N, Hartleben B, Koelink PJ, van Dijk SG, Peng WC, Verhoeven AJ, Oude Elferink RPJ, Chen HL, van de Graaf SFJ, Paulusma CC.   +18 more
europepmc   +2 more sources

Enantioselective Flow Synthesis of Rolipram Enabled by a Telescoped Asymmetric Conjugate Addition–Oxidative Aldehyde Esterification Sequence Using in Situ-Generated Persulfuric Acid as Oxidant

Organic Letters, 2022
A novel approach is reported for the enantioselective flow synthesis of rolipram comprising a telescoped asymmetric conjugate addition–oxidative aldehyde esterification sequence followed by trichlorosilane-mediated nitro group reduction and concomitant ...
Bence S. Nagy, P. Llanes, M. A. Pericàs, C. Kappe, Sándor B. Ötvös   +4 more
semanticscholar   +1 more source