Results 31 to 40 of about 7,547 (235)
Neurogastroenterology and Motility, 2022 Phosphodiesterase (PDE) inhibition has been reported to play a role in regulating gut motility, but the evidence is insufficient, and the mechanism remains unknown.
Fangting Yuan +4 more
semanticscholar +1 more source
Advancing PDE Inhibition: Preclinical Perspectives, Clinical Applications, and Future Therapeutics [PDF]
Alzheimers DementAbstract Background The phosphodiesterase enzyme family controls how much cyclic nucleotides such as cAMP and cGMP stay within cells. Research shows that blocking PDE enzyme activity helps treat many health problems including heart conditions, brain diseases, breathing disorders, and tumors.
Kamboj V.
europepmc +2 more sources
Effects of phosphodiesterase 4 inhibition on alveolarization and hyperoxia toxicity in newborn rats. [PDF]
PLoS ONE, 2008 BACKGROUND: Prolonged neonatal exposure to hyperoxia is associated with high mortality, leukocyte influx in airspaces, and impaired alveolarization.
Céline Méhats +9 more
doaj +1 more source
Effect of Rolipram on in vitro maturation, gene expression and embryonic development in bovines [PDF]
Arquivo Brasileiro de Medicina Veterinária e Zootecnia, 2019 The aim of this work was to evaluate the effect of the Rolipram during the maturation of bovine oocytes and gene expression of embryos produced in vitro. Bovine ovaries were collected in slaughterhouse.
B.B. Santana +7 more
doaj +1 more source
The therapeutic profile of rolipram, PDE target and mechanism of action as a neuroprotectant following spinal cord injury. [PDF]
PLoS ONE, 2012 The extent of damage following spinal cord injury (SCI) can be reduced by various neuroprotective regimens that include maintaining levels of cyclic adenosine monophosphate (cyclic AMP), via administration of the phosphodiesterase 4 (PDE4) inhibitor ...
Sandra Marie Schaal +10 more
doaj +1 more source
Scientific Reports, 2020 Sepsis is typically triggered by an overwhelming systemic inflammatory response to pathogens, and may lead to severe organ dysfunction and/or death. Sepsis consequently has a high mortality rate and a high rate of complications for survivors, despite ...
Xiaying Lu +4 more
semanticscholar +1 more source
Existence of rolipram‐sensitive phosphodiesterase in rat megakaryocyte [PDF]
British Journal of Pharmacology, 1993 The effect of rolipram (ME3176) on ADP‐ and IP3‐induced repetitive IK(Ca) in rat megakaryocyte was investigated by use of the nystatin perforated patch and conventional whole‐cell patch‐clamp techniques. The ADP‐induced IK(Ca) was depressed by treatment with rolipram in a concentration‐dependent manner.
N, Akaike +3 more
openaire +2 more sources
Differential Effects of PDE4 Inhibitors on Cortical Neurons and T-Lymphocytes
Journal of Pharmacological Sciences, 2008 Inhibitors of PDE4 (cAMP-specific phosphodiesterase) induce side effects, including nausea and emesis, that limit their therapeutic potential. We investigated the function of two catalytically active conformations of PDE4 (a low-affinity conformer ...
Ryo Hirose +4 more
doaj +1 more source
Potential PDE4B inhibitors as promising candidates against SARS‐CoV‐2 infection
Biomolecular Concepts, 2023 Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is an RNA virus belonging to the coronavirus family responsible for coronavirus disease 2019 (COVID-19).
Giuzio Federica +10 more
doaj +1 more source
Rolipram Inhibits Polarization and Migration of Human T Lymphocytes [PDF]
Journal of Investigative Dermatology, 2003 Phosphodiesterase inhibitors possess anti-inflammatory and immunomodulatory properties and seem to have a great potential in the treatment of inflammatory skin diseases; however, an overall study on the effects of specific phosphodiesterase inhibitors, such as rolipram on the processes involved in the extravasation of lymphoid cells has not been ...
Layseca-Espinosa, Esther +5 more
openaire +2 more sources