Results 31 to 40 of about 4,842 (209)
Mediators of Inflammation, 2016 Exposure to bacterial lipopolysaccharides (LPS) induces inflammatory signals in salivary glands. We investigated the regulatory role of phosphodiesterase 4 (PDE4) inhibitor rolipram on inflammatory mediators and cholinergic/adrenergic stimulation-induced
Dong Un Lee +2 more
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Potential PDE4B inhibitors as promising candidates against SARS‐CoV‐2 infection
Biomolecular Concepts, 2023 Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is an RNA virus belonging to the coronavirus family responsible for coronavirus disease 2019 (COVID-19).
Giuzio Federica +10 more
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Caffeine and rolipram affect Smad signalling and TGF-β1 stimulated CTGF and transgelin expression in lung epithelial cells. [PDF]
PLoS ONE, 2014 Caffeine administration is an important part of the therapeutic treatment of bronchopulmonary dysplasia (BPD) in preterm infants. However, caffeine mediated effects on airway remodelling are still undefined.
Markus Fehrholz +2 more
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HIV-1 gp120 Impairs Spatial Memory Through Cyclic AMP Response Element-Binding Protein
Frontiers in Aging Neuroscience, 2022 HIV-associated neurocognitive disorders (HAND) remain an unsolved problem that persists despite using antiretroviral therapy. We have obtained data showing that HIV-gp120 protein contributes to neurodegeneration through metabolic reprogramming.
Jenny Shrestha +26 more
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Phosphodiesterase 4B: Master Regulator of Brain Signaling
Cells, 2020 Phosphodiesterases (PDEs) are the only superfamily of enzymes that have the ability to break down cyclic nucleotides and, as such, they have a pivotal role in neurological disease and brain development. PDEs have a modular structure that allows targeting
Amy J. Tibbo, George S. Baillie
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Novel Liposomal Rolipram Formulation for Clinical Application to Reduce Emesis
Drug Design, Development and Therapy, 2022 Leila Gobejishvili,1 Walter E Rodriguez,1 Philip Bauer,2 Yali Wang,1 Chirag Soni,2 Todd Lydic,3 Shirish Barve,1 Craig McClain,1 Claudio Maldonado4 1Department of Medicine, School of Medicine, University of Louisville, Louisville, KY, USA; 2Endoprotech ...
Gobejishvili L +8 more
doaj
Rolipram Prevents the Formation of Abdominal Aortic Aneurysm (AAA) in Mice: PDE4B as a Target in AAA
Antioxidants, 2021 Abdominal aortic aneurysm (AAA) is a common life-threatening condition characterized by exacerbated inflammation and the generation of reactive oxygen species.
Saray Varona +10 more
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BMC Musculoskeletal Disorders, 2021 Background Fibrosis is an important factor and process of ligamentum flavum hypertrophy. The expression of phosphodiesterase family (PDE) is related to inflammation and fibrosis.
Likang Wu +8 more
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Chemical Stimulation of Rodent and Human Cortical Synaptosomes: Implications in Neurodegeneration
Cells, 2021 Synaptic plasticity events, including long-term potentiation (LTP), are often regarded as correlates of brain functions of memory and cognition. One of the central players in these plasticity-related phenomena is the α-amino-3-hydroxy-5-methylisoxazole-4-
Faraz Ahmad +3 more
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Stereospecificity of rolipram actions on eosinophil cyclic AMP-specific phosphodiesterase [PDF]
Biochemical Journal, 1993 The stereospecificity of rolipram inhibition of particulate cyclic AMP-specific phosphodiesterase (PDE IV) from guinea-pig eosinophils has been investigated. (-)-Rolipram (IC50 = 0.22 +/- 0.08 microM) was 2.5-fold more potent than (+)-rolipram (IC50 = 0.58 +/- 0.05 microM) in inhibiting membrane-bound PDE IV. Solubilization of PDE IV with deoxycholate (
L C Scott, J E Souness
openaire +3 more sources