Results 31 to 40 of about 4,908 (210)
Caffeine and rolipram affect Smad signalling and TGF-β1 stimulated CTGF and transgelin expression in lung epithelial cells. [PDF]
PLoS ONE, 2014 Caffeine administration is an important part of the therapeutic treatment of bronchopulmonary dysplasia (BPD) in preterm infants. However, caffeine mediated effects on airway remodelling are still undefined.
Markus Fehrholz +2 more
doaj +1 more source
Synaptic proteasome is inhibited in Alzheimer’s disease models and associates with memory impairment in mice [PDF]
Alzheimers DementAbstract Background The proteasome plays key roles in synaptic plasticity and memory by regulating protein turnover, quality control, and elimination of oxidized/misfolded proteins. Here, we investigate proteasome function and localization at synapses in Alzheimer’s disease (AD) post‐mortem brain tissue and in experimental models.
Ribeiro F +12 more
europepmc +2 more sources
Phosphodiesterase 4B: Master Regulator of Brain Signaling
Cells, 2020 Phosphodiesterases (PDEs) are the only superfamily of enzymes that have the ability to break down cyclic nucleotides and, as such, they have a pivotal role in neurological disease and brain development. PDEs have a modular structure that allows targeting
Amy J. Tibbo, George S. Baillie
doaj +1 more source
Chemical Stimulation of Rodent and Human Cortical Synaptosomes: Implications in Neurodegeneration
Cells, 2021 Synaptic plasticity events, including long-term potentiation (LTP), are often regarded as correlates of brain functions of memory and cognition. One of the central players in these plasticity-related phenomena is the α-amino-3-hydroxy-5-methylisoxazole-4-
Faraz Ahmad +3 more
doaj +1 more source
Rolipram Prevents the Formation of Abdominal Aortic Aneurysm (AAA) in Mice: PDE4B as a Target in AAA
Antioxidants, 2021 Abdominal aortic aneurysm (AAA) is a common life-threatening condition characterized by exacerbated inflammation and the generation of reactive oxygen species.
Saray Varona +10 more
doaj +1 more source
BMC Musculoskeletal Disorders, 2021 Background Fibrosis is an important factor and process of ligamentum flavum hypertrophy. The expression of phosphodiesterase family (PDE) is related to inflammation and fibrosis.
Likang Wu +8 more
doaj +1 more source
Stereospecificity of rolipram actions on eosinophil cyclic AMP-specific phosphodiesterase [PDF]
Biochemical Journal, 1993 The stereospecificity of rolipram inhibition of particulate cyclic AMP-specific phosphodiesterase (PDE IV) from guinea-pig eosinophils has been investigated. (-)-Rolipram (IC50 = 0.22 +/- 0.08 microM) was 2.5-fold more potent than (+)-rolipram (IC50 = 0.58 +/- 0.05 microM) in inhibiting membrane-bound PDE IV. Solubilization of PDE IV with deoxycholate (
L C Scott, J E Souness
openaire +3 more sources
Novel Liposomal Rolipram Formulation for Clinical Application to Reduce Emesis
Drug Design, Development and Therapy, 2022 Leila Gobejishvili,1 Walter E Rodriguez,1 Philip Bauer,2 Yali Wang,1 Chirag Soni,2 Todd Lydic,3 Shirish Barve,1 Craig McClain,1 Claudio Maldonado4 1Department of Medicine, School of Medicine, University of Louisville, Louisville, KY, USA; 2Endoprotech ...
Gobejishvili L +8 more
doaj
Angewandte Chemie International Edition, Volume 64, Issue 25, June 17, 2025.We present a metal‐free method for aromatic deuterium labeling via photoexcitation in deuterated HFIP. This approach leverages the enhanced basicity of excited‐state aromatics to achieve selective hydrogen isotope exchange at challenging positions. Demonstrated on complex drug molecules, this efficient strategy provides a valuable tool for isotope ...
Eva Rivera‐Chao +5 more
wiley +1 more source
Frontiers in Aging Neuroscience, 2018 Beta amyloid peptides (Aβ) are found to be associated with dysfunction of hypothalamic-pituitary-adrenal axis (HPA axis) that leads to memory and cognitive deficits in patients with Alzheimer's disease (AD). Phosphodiesterase 4 (PDE4) inhibitors increase
Ying Xu +12 more
doaj +1 more source