Results 41 to 50 of about 4,908 (210)

Molecular Mechanisms Underlying Apple Extract Ameliorates Depression‐Incident Cognitive Dysfunction Based on Network Pharmacology

Food Science &Nutrition, Volume 13, Issue 6, June 2025.
This study aimed to investigate the effects of apple extract (AE) on depression and its underlying mechanisms, revealing that AE may exert antidepressant effects by regulating inflammatory responses and the cAMP signaling pathway. Behavioral tests and biochemical analyses demonstrated that AE significantly improved depressive‐like behaviors and ...
Yue Chen, Shunqiang Yang, Huihuang Shi, Jizhe Cui, Zhu Li   +4 more
wiley   +1 more source

Targeting Cancer Cell Proliferation Using Piperazine‐Linked Quinolinequinones: Mechanism and Metabolic Profile

Chemical Biology &Drug Design, Volume 105, Issue 6, June 2025.
We examined the quinolinequinones' (QQ1‐ 7) effects on cancer cell lines. The most potent compound was QQ1 against ACHN cells with an IC50 value of 1.5 ± 0.16 μM. For better understanding, the effects of QQ1 on apoptosis, cell cycle, and oxidative stress were investigated. QQ1 inhibited ACHN cell proliferation via cell cycle arrest.
Ayse Mine Yilmaz, Ayse Tarbin Jannuzzi, Abanish Biswas, Subodh Mondal, Vinay N. Basavanakatti, Hatice Yıldırım, Mahmut Yıldız, Nilüfer Bayrak, Venkatesan Jayaprakash, Amaç Fatih TuYuN   +9 more
wiley   +1 more source

Reversing Alzheimer's disease dementia with clemastine, fingolimod, or rolipram, plus anti‐amyloid therapy

Alzheimer’s & Dementia: Translational Research & Clinical Interventions, 2022
A few anti‐amyloid trials offer a slight possibility of preventing progression of cognitive loss, but none has reversed the process. A possible reason is that amyloid may be necessary but insufficient in the pathogenesis of AD, and other causal factors ...
Jeffrey Fessel
doaj   +1 more source

Inhibition of hippocampal mossy fiber plasticity and episodic memory by human Aβ oligomers is prevented by enhancing cAMP signaling in Alzheimer's mice

Alzheimer's &Dementia, Volume 21, Issue 4, April 2025.
Abstract INTRODUCTION Early episodic memory impairment in Alzheimer's disease (AD) is linked to synaptic dysfunction from amyloid β‐protein oligomers (oAβ), particularly affecting the dentate gyrus mossy fiber‐CA3 pathway. The APPNL‐G‐F mouse model exhibits early deficits in mossy fiber long‐term potentiation (mf‐LTP).
Shan‐Xue Jin, Jean‐Pierre Bellier, Adrienne Wells, Paula Montero LIopis, Praju Vikas Anekal, Jason S. Tresback, Barbara J. Caldarone, Lei Liu, Shaomin Li, Ulf Dettmer, Nagendran Ramalingam, Dennis J. Selkoe   +11 more
wiley   +1 more source

Lipidic nanocapsule drug delivery: neuronal protection for cochlear implant optimization

International Journal of Nanomedicine, 2012
Hartwig Meyer,1,2 Timo Stöver,1,3 Florian Fouchet,4 Guillaume Bastiat,4 Patrick Saulnier,4 Wolfgang Bäumer,2 Thomas Lenarz,1 Verena Scheper,11Department of Otolaryngology, Hannover Medical School, 2Institute for Pharmacology, Toxicology
Meyer H, Stöver T, Fouchet F, Bastiat G, Saulnier P, Bäumer W, Lenarz T, Scheper V   +7 more
doaj  

Combining Neurotrophin-Transduced Schwann Cells and Rolipram to Promote Functional Recovery from Subacute Spinal Cord Injury

Cell Transplantation, 2013
Following spinal cord injury (SCI), both an inhibitory environment and lack of intrinsic growth capacity impede axonal regeneration. In a previous study, prevention of cyclic adenosine monophosphate (AMP) hydrolysis by the phosphodiesterase-4 inhibitor ...
Govinder Flora, Gravil Joseph, Samik Patel, Amanpreet Singh, Drew Bleicher, David J. Barakat, Jack Louro, Stephanie Fenton, Maneesh Garg, Mary Bartlett Bunge, Damien D. Pearse Ph.D   +10 more
doaj   +1 more source

Risk Factors, Pathological Changes, and Potential Treatment of Diabetes‐Associated Cognitive Dysfunction

Journal of Diabetes, Volume 17, Issue 4, April 2025.
ABSTRACT Background Diabetes is a prevalent public health issue worldwide, and the cognitive dysfunction and subsequent dementia caused by it seriously affect the quality of life of patients. Methods Recent studies were reviewed to provide a comprehensive summary of the risk factors, pathogenesis, pathological changes and potential drug treatments for ...
Xiaoyu Meng, Haiyang Du, Danpei Li, Yaming Guo, Peiqiong Luo, Limeng Pan, Ranran Kan, Peng Yu, Yuxi Xiang, Beibei Mao, Yi He, Siyi Wang, Wenjun Li, Yan Yang, Xuefeng Yu   +14 more
wiley   +1 more source

The Role of Protein Kinase B Signaling Pathway in Anti-cancer Effect of Rolipram on Glioblastoma Multiforme: An In Vitro Study

Basic and Clinical Neuroscience, 2017
Introduction: The mechanism of putative cytotoxicity of 4-[3-(cyclopentyloxy)-4-methoxyphenyl]-2-pyrrolidone (rolipram), a specific phosphodiesterase-4 (PDE4) inhibitor, on glioblastoma multiforme (GBM) is almost unknown.
Sara Ramezani, Mahmoudreza Hadjighassem, Nasim Vousooghi, Mansour Parvaresh, Farshid Arbabi, Naser Amini, Mohammad Taghi Joghataei   +6 more
doaj  

Untersuchungen zum neuroprotektiven Effekt von Rolipram und nanopartikel-vermittelter Rolipram Applikation

, 2011
82.
Scheper, V, Meyer, H, Stöver, T, Lenarz, T, Saulnier, P, Bastiat, G   +5 more
openaire   +2 more sources

The Effects of a Selective cAMP Phosphodiesterase Inhibitor, Rolipram, on Methamphetamine-Induced Behavior [PDF]

Neuropsychopharmacology, 1995
The effects of rolipram, a selective cAMP phosphodiesterase inhibitor, on locomotor activity, rearing, and stereotyped behavior (sniffing, repetitive head movements) induced by methamphetamine (MAP) over 1 hour were investigated in rats. Coadministration of rolipram (4 mg/kg IP) significantly attenuated the responses of locomotor activity, rearing and ...
Toshiya Inada, Yohko Maeda, Susumu Fukui, Hajime Sasaki, Masaomi Iyo, Yoshie Kitao   +5 more
openaire   +3 more sources