Results 41 to 50 of about 4,842 (209)

Inhibition of Phosphodiesterase-4 Reverses Aβ-Induced Memory Impairment by Regulation of HPA Axis Related cAMP Signaling

Frontiers in Aging Neuroscience, 2018
Beta amyloid peptides (Aβ) are found to be associated with dysfunction of hypothalamic-pituitary-adrenal axis (HPA axis) that leads to memory and cognitive deficits in patients with Alzheimer's disease (AD). Phosphodiesterase 4 (PDE4) inhibitors increase
Ying Xu, Ying Xu, Naping Zhu, Wen Xu, Han Ye, Kaiping Liu, Feiyan Wu, Meixi Zhang, Yun Ding, Chong Zhang, Hanting Zhang, James O'Donnell, Jiangchun Pan   +12 more
doaj   +1 more source

Inhibition of the upregulated phosphodiesterase 4D isoforms improves SERCA2a function in diabetic cardiomyopathy

British Journal of Pharmacology, Volume 182, Issue 7, Page 1487-1507, April 2025.
Abstract Background and Purpose Sarcoplasmic reticulum Ca2+‐ATPase (SERCA2a) is impaired in heart failure. Phosphodiesterases (PDEs) are implicated in the modulation of local cAMP signals and protein kinase A (PKA) activity essential for cardiac function.
Zhenduo Zhu, Qiuyun Guan, Bing Xu, Sherif Bahriz, Ao Shen, Toni M. West, Yu Zhang, Bingqing Deng, Wei Wei, Yongsheng Han, Qingtong Wang, Yang K. Xiang   +11 more
wiley   +1 more source

Cross‐pathway integration of cAMP signals through cGMP and calcium‐regulated phosphodiesterases in mouse striatal cholinergic interneurons

British Journal of Pharmacology, Volume 182, Issue 5, Page 1236-1253, March 2025.
Abstract Background and Purpose Acetylcholine plays a key role in striatal function. Firing properties of striatal cholinergic interneurons depend on intracellular cAMP through the regulation of Ih currents. Yet, the dynamics of cyclic nucleotide signalling in these neurons have remained elusive.
Ségolène Bompierre, Yelyzaveta Byelyayeva, Elia Mota, Marion Lefevre, Anna Pumo, Jan Kehler, Liliana R. V. Castro, Pierre Vincent   +7 more
wiley   +1 more source

The Effects of a Selective cAMP Phosphodiesterase Inhibitor, Rolipram, on Methamphetamine-Induced Behavior [PDF]

Neuropsychopharmacology, 1995
The effects of rolipram, a selective cAMP phosphodiesterase inhibitor, on locomotor activity, rearing, and stereotyped behavior (sniffing, repetitive head movements) induced by methamphetamine (MAP) over 1 hour were investigated in rats. Coadministration of rolipram (4 mg/kg IP) significantly attenuated the responses of locomotor activity, rearing and ...
Toshiya Inada, Yohko Maeda, Susumu Fukui, Hajime Sasaki, Masaomi Iyo, Yoshie Kitao   +5 more
openaire   +3 more sources

Visible Light‐Mediated Decarboxylative Giese Addition Utilizing Thioxanthone or Thioxanthone‐TfOH Complex as the Photocatalyst

Chemistry – A European Journal, Volume 31, Issue 12, February 25, 2025.
Photochemistry: A cheap, metal‐free, photochemical protocol for the 1,4‐decarboxylative addition between carboxylic acids and electron‐deficient olefins, under irradiation at 427 nm, utilizing the cheap, metal‐free, commercially available, thioxanthone or thioxanthone‐TfOH complex as the suitable photocatalyst.
Charikleia S. Batsika, Naya A. Stini, Christoforos G. Kokotos   +2 more
wiley   +1 more source

Lipidic nanocapsule drug delivery: neuronal protection for cochlear implant optimization

International Journal of Nanomedicine, 2012
Hartwig Meyer,1,2 Timo Stöver,1,3 Florian Fouchet,4 Guillaume Bastiat,4 Patrick Saulnier,4 Wolfgang Bäumer,2 Thomas Lenarz,1 Verena Scheper,11Department of Otolaryngology, Hannover Medical School, 2Institute for Pharmacology, Toxicology
Meyer H, Stöver T, Fouchet F, Bastiat G, Saulnier P, Bäumer W, Lenarz T, Scheper V   +7 more
doaj  

Combining Neurotrophin-Transduced Schwann Cells and Rolipram to Promote Functional Recovery from Subacute Spinal Cord Injury

Cell Transplantation, 2013
Following spinal cord injury (SCI), both an inhibitory environment and lack of intrinsic growth capacity impede axonal regeneration. In a previous study, prevention of cyclic adenosine monophosphate (AMP) hydrolysis by the phosphodiesterase-4 inhibitor ...
Govinder Flora, Gravil Joseph, Samik Patel, Amanpreet Singh, Drew Bleicher, David J. Barakat, Jack Louro, Stephanie Fenton, Maneesh Garg, Mary Bartlett Bunge, Damien D. Pearse Ph.D   +10 more
doaj   +1 more source

Reversing Alzheimer's disease dementia with clemastine, fingolimod, or rolipram, plus anti‐amyloid therapy

Alzheimer’s & Dementia: Translational Research & Clinical Interventions, 2022
A few anti‐amyloid trials offer a slight possibility of preventing progression of cognitive loss, but none has reversed the process. A possible reason is that amyloid may be necessary but insufficient in the pathogenesis of AD, and other causal factors ...
Jeffrey Fessel
doaj   +1 more source

Untersuchungen zum neuroprotektiven Effekt von Rolipram und nanopartikel-vermittelter Rolipram Applikation

, 2011
82.
Scheper, V, Meyer, H, Stöver, T, Lenarz, T, Saulnier, P, Bastiat, G   +5 more
openaire   +2 more sources

Malnutrition exacerbating neuropsychiatric symptoms on the Alzheimer's continuum is relevant to the cAMP signaling pathway: Human and mouse studies

Alzheimer's &Dementia, Volume 21, Issue 2, February 2025.
Abstract INTRODUCTION Malnutrition correlates with neuropsychiatric symptoms (NPSs) in Alzheimer's disease (AD); however, the potential mechanism underlying this association remains unclear. METHODS Baseline and longitudinal associations of nutritional status with NPSs were analyzed in 374 patients on the AD continuum and 61 healthy controls.
Jiwei Jiang, Tianlin Jiang, Xiaohong Wang, Min Zhao, Hanping Shi, Huiying Zhang, Wenyi Li, Shirui Jiang, Xiaoli Zhang, Jiawei Zhou, Qiwei Ren, Linlin Wang, Shiyi Yang, Zeshan Yao, Yaou Liu, Jun Xu   +15 more
wiley   +1 more source