Chemical Stimulation of Rodent and Human Cortical Synaptosomes: Implications in Neurodegeneration
Cells, 2021 Synaptic plasticity events, including long-term potentiation (LTP), are often regarded as correlates of brain functions of memory and cognition. One of the central players in these plasticity-related phenomena is the α-amino-3-hydroxy-5-methylisoxazole-4-
Faraz Ahmad +3 more
doaj +1 more source
Synergistic effect of phosphodiesterase 4 inhibitor and serum on migration of endotoxin-stimulated macrophages. [PDF]
, 2018 Macrophage migration is an essential step in host defense against infection and wound healing. Elevation of cAMP by inhibiting phosphodiesterase 4 (PDE4), enzymes that specifically degrade cAMP, is known to suppress various inflammatory responses in ...
Catherine Jin, S-L +7 more
core
The low KM-phosphodiesterase inhibitor denbufylline enhances neuronal excitability in guinea pig hippocampus in vitro [PDF]
, 1990 The actions of the phosphodiesterase inhibitor denbufylline on the excitability of hippocampal neurons were investigated by means of extracellular and intracellular recordings.
Alzheimer, Christian +3 more
core +1 more source
Frontiers in Aging Neuroscience, 2018 Beta amyloid peptides (Aβ) are found to be associated with dysfunction of hypothalamic-pituitary-adrenal axis (HPA axis) that leads to memory and cognitive deficits in patients with Alzheimer's disease (AD). Phosphodiesterase 4 (PDE4) inhibitors increase
Ying Xu +12 more
doaj +1 more source
Phosphorylation of ezrin on Thr567 is required for the synergistic activation of cell spreading by EPAC1 and protein kinase A in HEK293T cells [PDF]
, 2015 Recent studies have demonstrated that the actin binding protein, ezrin, and the cAMP-sensor, EPAC1, cooperate to induce cell spreading in response to elevations in intracellular cAMP.
Baillie, Gemma L. +8 more
core +2 more sources
The PDE4 inhibitor rolipram reverses object memory impairment induced by acute tryptophan depletion in the rat [PDF]
, 2007 The selective type IV phosphodiesterase inhibitor, rolipram, has been shown to improve long-term memory and can reverse the cholinergic deficit caused by scopolamine. However, the underlying mechanisms of action of rolipram remain obscure.
A. Blokland +3 more
core +2 more sources
The Effects of a Selective cAMP Phosphodiesterase Inhibitor, Rolipram, on Methamphetamine-Induced Behavior [PDF]
Neuropsychopharmacology, 1995 The effects of rolipram, a selective cAMP phosphodiesterase inhibitor, on locomotor activity, rearing, and stereotyped behavior (sniffing, repetitive head movements) induced by methamphetamine (MAP) over 1 hour were investigated in rats. Coadministration of rolipram (4 mg/kg IP) significantly attenuated the responses of locomotor activity, rearing and ...
Toshiya Inada +5 more
openaire +3 more sources
Lipidic nanocapsule drug delivery: neuronal protection for cochlear implant optimization
International Journal of Nanomedicine, 2012 Hartwig Meyer,1,2 Timo Stöver,1,3 Florian Fouchet,4 Guillaume Bastiat,4 Patrick Saulnier,4 Wolfgang Bäumer,2 Thomas Lenarz,1 Verena Scheper,11Department of Otolaryngology, Hannover Medical School, 2Institute for Pharmacology, Toxicology
Meyer H +7 more
doaj
Cell Transplantation, 2013 Following spinal cord injury (SCI), both an inhibitory environment and lack of intrinsic growth capacity impede axonal regeneration. In a previous study, prevention of cyclic adenosine monophosphate (AMP) hydrolysis by the phosphodiesterase-4 inhibitor ...
Govinder Flora +10 more
doaj +1 more source