Results 51 to 60 of about 7,547 (235)

Therapy for X-adrenoleukodystrophy: normalization of very long chain fatty acids and inhibition of induction of cytokines by cAMP

Journal of Lipid Research, 1998
X-adrenoleukodystrophy (X-ALD) is an inherited fatty acid metabolic disorder with secondary manifestation of neuroinflammatory disease process. We report that compounds (forskolin, 8-bromo cAMP, and rolipram) that increase cAMP and activate protein ...
Kalipada Pahan, Mushfiquddin Khan, Inderjit Singh   +2 more
doaj   +1 more source

Stereospecificity of rolipram actions on eosinophil cyclic AMP-specific phosphodiesterase [PDF]

Biochemical Journal, 1993
The stereospecificity of rolipram inhibition of particulate cyclic AMP-specific phosphodiesterase (PDE IV) from guinea-pig eosinophils has been investigated. (-)-Rolipram (IC50 = 0.22 +/- 0.08 microM) was 2.5-fold more potent than (+)-rolipram (IC50 = 0.58 +/- 0.05 microM) in inhibiting membrane-bound PDE IV. Solubilization of PDE IV with deoxycholate (
J E, Souness, L C, Scott
openaire   +2 more sources

Oligodendrocyte Precursor Cells in Demyelination Repair: Mechanisms, Crosstalk, and Therapeutic Frontiers

Medicine Bulletin, Volume 1, Issue 2, Page 104-120, December 2025.
ABSTRACT In multiple sclerosis (MS), demyelination is often accompanied by severe motor and cognitive disability. Remyelination is the process of regenerating new myelin sheath on impaired axons, which is typically carried out by oligodendrocyte precursor cells (OPCs).
Zixin Gao, Mengdi Guo, Kehan Chen, Mei‐Ling Jiang, Lin‐ming Zhang, Lorenzo Di Cesare Mannelli, Cun‐jin Zhang   +6 more
wiley   +1 more source

The Concise Guide to PHARMACOLOGY 2025/26: Enzymes

British Journal of Pharmacology, Volume 182, Issue S1, Page S307-S403, December 2025.
The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander, Doriano Fabbro, Alasdair J. Gibb, Eamonn Kelly, Alistair A. Mathie, Chloe J. Peach, Emma L. Veale, Jane F. Armstrong, Elena Faccenda, Simon D. Harding, Christopher Southan, Jamie A. Davies, Stephanie Annett, Detlev Boison, Kathryn Elisa Burns, Carmen Dessauer, Jürg Gertsch, Nuala Ann Helsby, Angelo A. Izzo, Rennolds Ostrom, Ester Pagano, Andreas Papapetropoulos, Nigel J. Pyne, Susan Pyne, Tracy Robson, Roland Seifert, Johannes‐Peter Stasch, Csaba Szabo, Mario van der Stelt, Albert van der Vliet, Val Watts, Szu Shen Wong   +31 more
wiley   +1 more source

Lipidic nanocapsule drug delivery: neuronal protection for cochlear implant optimization

International Journal of Nanomedicine, 2012
Hartwig Meyer,1,2 Timo Stöver,1,3 Florian Fouchet,4 Guillaume Bastiat,4 Patrick Saulnier,4 Wolfgang Bäumer,2 Thomas Lenarz,1 Verena Scheper,11Department of Otolaryngology, Hannover Medical School, 2Institute for Pharmacology, Toxicology
Meyer H, Stöver T, Fouchet F, Bastiat G, Saulnier P, Bäumer W, Lenarz T, Scheper V   +7 more
doaj  

Combining Neurotrophin-Transduced Schwann Cells and Rolipram to Promote Functional Recovery from Subacute Spinal Cord Injury

Cell Transplantation, 2013
Following spinal cord injury (SCI), both an inhibitory environment and lack of intrinsic growth capacity impede axonal regeneration. In a previous study, prevention of cyclic adenosine monophosphate (AMP) hydrolysis by the phosphodiesterase-4 inhibitor ...
Govinder Flora, Gravil Joseph, Samik Patel, Amanpreet Singh, Drew Bleicher, David J. Barakat, Jack Louro, Stephanie Fenton, Maneesh Garg, Mary Bartlett Bunge, Damien D. Pearse Ph.D   +10 more
doaj   +1 more source

Changes in the expression of extracellular regulated kinase (ERK 1/2) in the R6/2 mouse model of Huntington's disease after phosphodiesterase IV inhibition

Neurobiology of Disease, 2012
The mitogen-activated protein kinases (MAPKs) superfamily comprises three major signaling pathways: the extracellular signal-regulated protein kinases (ERKs), the c-Jun N-terminal kinases or stress-activated protein kinases (JNKs/SAPKs) and the p38 ...
Francesca R. Fusco, Serenella Anzilotti, Carmela Giampà, Clemente Dato, Daunia Laurenti, Alessandro Leuti, Luca Colucci D'Amato, Lorena Perrone, Giorgio Bernardi, Mariarosa A.B. Melone   +9 more
doaj   +1 more source

Enantioselective Desymmetrization by Chiral Bifunctional H‐Bonding Organocatalysts

Chemistry – A European Journal, Volume 31, Issue 61, November 3, 2025.
Enantioselective desymmetrization has emerged as a highly efficient and conceptually elegant strategy for the construction of chiral molecules from readily available prochiral substrates. This review focuses on recent developments in organocatalytic desymmetrization reactions, with particular emphasis on approaches involving bifunctional activation ...
Michal Urban, Jan Veselý
wiley   +1 more source

The role of cyclic nucleotide phosphodiesterases in the regulation of adipocyte lipolysis

Journal of Lipid Research, 2005
This study assessed the effects of selective inhibitors of 3′,5′-cyclic nucleotide phosphodiesterases (PDEs) on adipocyte lipolysis. IC224, a selective inhibitor of type 1 phosphodiesterase (PDE1), suppressed lipolysis in murine 3T3-L1 adipocytes (69.6 ±
Peter B. Snyder, James M. Esselstyn, Kate Loughney, Sharon L. Wolda, Vincent A. Florio   +4 more
doaj   +1 more source

The analgesic effect of rolipram is associated with the inhibition of the activation of the spinal astrocytic JNK/CCL2 pathway in bone cancer pain

International Journal of Molecular Medicine, 2016
Bone cancer pain (BCP) is one of the most difficult and intractable tasks for pain management, which is associated with spinal 'neuron-astrocytic' activation.
Chi-hua Guo, Lu Bai, Huang-Hui Wu, Jing Yang, Guo-hong Cai, X. Wang, Sheng-Xi Wu, Wei Ma   +7 more
semanticscholar   +1 more source