Results 71 to 80 of about 7,547 (235)
Frontiers in Cellular Neuroscience, 2016 Rett syndrome (RTT) patients experience learning difficulties and memory loss. Analogous deficits of hippocampal plasticity are reported in mouse models of RTT.
Saju Balakrishnan +2 more
semanticscholar +1 more source
Cancer Medicine, Volume 14, Issue 18, September 2025.ABSTRACT Colorectal cancer (CRC) is a major cause of cancer‐related mortality, especially in the Western world, and its incidence is expected to increase in the years to come. Prevention and early detection are key strategies to improve CRC morbidity and mortality.
Ulrike Ries Feddersen +5 more
wiley +1 more source
European Journal of Entomology, 2017 Feeding in codling moth neonate caterpillars was inhibited by 0.67 mM and 2.24 mM concentrations of denatonium benzoate. This inhibitory effect was abolished by phospholipase C inhibitor, U-73122 and the phosphodiesterase inhibitor, Rolipram. Quinine and
Maciej A. PSZCZOLKOWSKI
doaj +1 more source
Journal of Cellular and Molecular Medicine, Volume 29, Issue 16, August 2025.ABSTRACT Prostate cancer (PCa) is an extremely heterogeneous cancer and is highly prevalent in the older male population. Since intra‐tumour heterogeneity (ITH) commonly results in PCa chemotherapy resistance and recurrence, it is critical to explore its effects on tumour behaviour.
Junchao Wu +8 more
wiley +1 more source
Potent PDE4 inhibitor activates AMPK and Sirt1 to induce mitochondrial biogenesis.
PLoS ONE, 2021 AMP-activated protein kinase (AMPK) is an evolutionarily conserved energy sensor. Activation of AMPK leads to a number of metabolic benefits, including improved mitochondrial function in skeletal muscle and lowering of serum glucose levels in type-2 ...
Sung-Jun Park +8 more
doaj +1 more source
Rolipram: A specific phosphodiesterase 4 inhibitor with potential antipsychotic activity [PDF]
Neuroscience, 2007 Currently available antipsychotic medications work primarily by antagonizing D2 dopamine receptors, thus raising intracellular cAMP levels. We hypothesized that intracellular stimulation of cAMP levels in the CNS would have similar effects to treatment with antipsychotic medication.
S J, Kanes +5 more
openaire +2 more sources
Angewandte Chemie, Volume 137, Issue 25, June 17, 2025.Wir präsentieren eine metallfreie Methode für die Deuteriummarkierung von Aromaten in deuteriertem HFIP. Dieser Ansatz nutzt die erhöhte Basizität von Aromaten im angeregten Zustand, um den selektiven Wasserstoffisotopenaustausch an schwer zugänglichen Positionen zu ermöglichen.
Eva Rivera‐Chao +5 more
wiley +1 more source
Angewandte Chemie International Edition, Volume 64, Issue 25, June 17, 2025.We present a metal‐free method for aromatic deuterium labeling via photoexcitation in deuterated HFIP. This approach leverages the enhanced basicity of excited‐state aromatics to achieve selective hydrogen isotope exchange at challenging positions. Demonstrated on complex drug molecules, this efficient strategy provides a valuable tool for isotope ...
Eva Rivera‐Chao +5 more
wiley +1 more source
Food Science &Nutrition, Volume 13, Issue 6, June 2025.This study aimed to investigate the effects of apple extract (AE) on depression and its underlying mechanisms, revealing that AE may exert antidepressant effects by regulating inflammatory responses and the cAMP signaling pathway. Behavioral tests and biochemical analyses demonstrated that AE significantly improved depressive‐like behaviors and ...
Yue Chen +4 more
wiley +1 more source
Chemical Biology &Drug Design, Volume 105, Issue 6, June 2025.We examined the quinolinequinones' (QQ1‐ 7) effects on cancer cell lines. The most potent compound was QQ1 against ACHN cells with an IC50 value of 1.5 ± 0.16 μM. For better understanding, the effects of QQ1 on apoptosis, cell cycle, and oxidative stress were investigated. QQ1 inhibited ACHN cell proliferation via cell cycle arrest.
Ayse Mine Yilmaz +9 more
wiley +1 more source