Results 71 to 80 of about 11,777 (278)

Rolipram stimulates angiogenesis and attenuates neuronal apoptosis through the cAMP/cAMP-responsive element binding protein pathway following ischemic stroke in rats.

Experimental and Therapeutic Medicine, 2016
Rolipram, a phosphodiesterase-4 inhibitor, can activate the cyclic adenosine monophosphate (cAMP)/cAMP-responsive element binding protein (CREB) pathway to facilitate functional recovery following ischemic stroke.
Shouye Hu, Qingwen Cao, P. Xu, W. Ji, G. Wang, Yue-Lin Zhang   +5 more
semanticscholar   +1 more source

Inhibition of Phosphodiesterase-4 Reverses Aβ-Induced Memory Impairment by Regulation of HPA Axis Related cAMP Signaling

Frontiers in Aging Neuroscience, 2018
Beta amyloid peptides (Aβ) are found to be associated with dysfunction of hypothalamic-pituitary-adrenal axis (HPA axis) that leads to memory and cognitive deficits in patients with Alzheimer's disease (AD). Phosphodiesterase 4 (PDE4) inhibitors increase
Ying Xu, Ying Xu, Naping Zhu, Wen Xu, Han Ye, Kaiping Liu, Feiyan Wu, Meixi Zhang, Yun Ding, Chong Zhang, Hanting Zhang, James O'Donnell, Jiangchun Pan   +12 more
doaj   +1 more source

The role of c-Jun in controlling the EPAC1-dependent induction of the SOCS3 gene in HUVECs [PDF]

, 2014
The cyclic AMP sensor, EPAC1, activates AP1-mediated transcription in HUVECs. Correspondingly, induction of the SOCS3 minimal promoter by EPAC1 requires a single AP1 site that constitutively binds phosphorylated (Ser63) c-Jun in DNA-pull-down assays.
Auernhammer, Bos, Cai, Curran, Davis, Eid, Hochbaum, Jolanta Wiejak, Julia Dunlop, Karin, MacLaren, Meinkoth, Netherton, Piessevaux, Ramberg, Rampersad, Sands, Schmidt, Stephen J. Yarwood, Wiejak, Wiejak, Woolson, Yarwood, Yarwood   +23 more
core   +1 more source

Delineation of RAID1, the RACK1 interaction domain located within the unique N-terminal region of the cAMP-specific phosphodiesterase, PDE4D5 [PDF]

, 2002
Background The cyclic AMP specific phosphodiesterase, PDE4D5 interacts with the β-propeller protein RACK1 to form a signaling scaffold complex in cells.
Bolger, G.B., Houslay, M., McCahill, A., Steele, M.R., Warwicker, J., Yarwood, S.   +5 more
core   +3 more sources

Inhibition of hippocampal mossy fiber plasticity and episodic memory by human Aβ oligomers is prevented by enhancing cAMP signaling in Alzheimer's mice

Alzheimer's &Dementia, Volume 21, Issue 4, April 2025.
Abstract INTRODUCTION Early episodic memory impairment in Alzheimer's disease (AD) is linked to synaptic dysfunction from amyloid β‐protein oligomers (oAβ), particularly affecting the dentate gyrus mossy fiber‐CA3 pathway. The APPNL‐G‐F mouse model exhibits early deficits in mossy fiber long‐term potentiation (mf‐LTP).
Shan‐Xue Jin, Jean‐Pierre Bellier, Adrienne Wells, Paula Montero LIopis, Praju Vikas Anekal, Jason S. Tresback, Barbara J. Caldarone, Lei Liu, Shaomin Li, Ulf Dettmer, Nagendran Ramalingam, Dennis J. Selkoe   +11 more
wiley   +1 more source

The low KM-phosphodiesterase inhibitor denbufylline enhances neuronal excitability in guinea pig hippocampus in vitro [PDF]

, 1990
The actions of the phosphodiesterase inhibitor denbufylline on the excitability of hippocampal neurons were investigated by means of extracellular and intracellular recordings.
Alzheimer, Christian, Ameri, A., Sutor, Bernd, Ten Bruggencate, Gerrit   +3 more
core   +1 more source

Risk Factors, Pathological Changes, and Potential Treatment of Diabetes‐Associated Cognitive Dysfunction

Journal of Diabetes, Volume 17, Issue 4, April 2025.
ABSTRACT Background Diabetes is a prevalent public health issue worldwide, and the cognitive dysfunction and subsequent dementia caused by it seriously affect the quality of life of patients. Methods Recent studies were reviewed to provide a comprehensive summary of the risk factors, pathogenesis, pathological changes and potential drug treatments for ...
Xiaoyu Meng, Haiyang Du, Danpei Li, Yaming Guo, Peiqiong Luo, Limeng Pan, Ranran Kan, Peng Yu, Yuxi Xiang, Beibei Mao, Yi He, Siyi Wang, Wenjun Li, Yan Yang, Xuefeng Yu   +14 more
wiley   +1 more source

Phosphorylation of ezrin on Thr567 is required for the synergistic activation of cell spreading by EPAC1 and protein kinase A in HEK293T cells [PDF]

, 2015
Recent studies have demonstrated that the actin binding protein, ezrin, and the cAMP-sensor, EPAC1, cooperate to induce cell spreading in response to elevations in intracellular cAMP.
Baillie, Gemma L., Baillie, George S., Cameron, Ryan T., Koschinski, Andreas, McElroy, Stuart P., Parnell, Euan, Porter, Alison, Yarwood, Stephen J., Zaccolo, Manuela   +8 more
core   +2 more sources

The Effects of a Selective cAMP Phosphodiesterase Inhibitor, Rolipram, on Methamphetamine-Induced Behavior [PDF]

Neuropsychopharmacology, 1995
The effects of rolipram, a selective cAMP phosphodiesterase inhibitor, on locomotor activity, rearing, and stereotyped behavior (sniffing, repetitive head movements) induced by methamphetamine (MAP) over 1 hour were investigated in rats. Coadministration of rolipram (4 mg/kg IP) significantly attenuated the responses of locomotor activity, rearing and ...
Toshiya Inada, Yohko Maeda, Susumu Fukui, Hajime Sasaki, Masaomi Iyo, Yoshie Kitao   +5 more
openaire   +3 more sources

Inhibition of the upregulated phosphodiesterase 4D isoforms improves SERCA2a function in diabetic cardiomyopathy

British Journal of Pharmacology, Volume 182, Issue 7, Page 1487-1507, April 2025.
Abstract Background and Purpose Sarcoplasmic reticulum Ca2+‐ATPase (SERCA2a) is impaired in heart failure. Phosphodiesterases (PDEs) are implicated in the modulation of local cAMP signals and protein kinase A (PKA) activity essential for cardiac function.
Zhenduo Zhu, Qiuyun Guan, Bing Xu, Sherif Bahriz, Ao Shen, Toni M. West, Yu Zhang, Bingqing Deng, Wei Wei, Yongsheng Han, Qingtong Wang, Yang K. Xiang   +11 more
wiley   +1 more source