Rolipram - Open Access .click

Results 71 to 80 of about 4,908 (210)

Inhibition of Uterine Contractility by Thalidomide Analogs via Phosphodiesterase-4 Inhibition and Calcium Entry Blockade

Molecules, 2016
Uterine relaxation is crucial during preterm labor. Phosphodiesterase-4 (PDE-4) inhibitors have been proposed as tocolytics. Some thalidomide analogs are PDE-4 inhibitors.
Eduardo Fernández-Martínez +6 more
doaj +1 more source

Image-derived input function derived from a supervised clustering algorithm: methodology and validation in a clinical protocol using [11C](R)-rolipram.

PLoS ONE, 2014
Image-derived input function (IDIF) obtained by manually drawing carotid arteries (manual-IDIF) can be reliably used in [(11)C](R)-rolipram positron emission tomography (PET) scans.
Chul Hyoung Lyoo +8 more
doaj +1 more source

Fear renewal activates cyclic adenosine monophosphate signaling in the dentate gyrus

Brain and Behavior, 2019
Background Fear renewal, the context‐specific relapse of a conditioned fear after extinction, is a widely pursued model of post‐traumatic stress disorder and phobias. However, its cellular and molecular mechanisms remain poorly understood.
Yan-Wei Shi +4 more
doaj +1 more source

Modulation of oxazolone-induced hypersensitivity in mice by selective PDE inhibitors

Mediators of Inflammation, 1995
The effects of PDE inhibitors on oxazolone-induced contact hypersensitivity (CS) were studied in mice. Rolipram, Ro 20-1724 and theophylline dose dependently inhibited CS but none caused >53% inhibition. ED30 values at 24 h before challenge for rolipram,
I. Moodley, Y. Sotsios, B. Bertin
doaj +1 more source

Phosphodiesterase 4B is essential for lipopolysaccharide-induced CC chemokine ligand 3 production in mouse macrophages

Journal of Medical Sciences, 2015
Background: Phosphodiesterase 4 (PDE4) inhibitors negatively modulate many inflammatory responses, and some of these pharmacological effects are mediated by inhibition of PDE4B in inflammatory cells.
Ciou-Rong Lai +8 more
doaj +1 more source

Therapy for X-adrenoleukodystrophy: normalization of very long chain fatty acids and inhibition of induction of cytokines by cAMP

Journal of Lipid Research, 1998
X-adrenoleukodystrophy (X-ALD) is an inherited fatty acid metabolic disorder with secondary manifestation of neuroinflammatory disease process. We report that compounds (forskolin, 8-bromo cAMP, and rolipram) that increase cAMP and activate protein ...
Kalipada Pahan, Mushfiquddin Khan, Inderjit Singh +2 more
doaj

Changes in the expression of extracellular regulated kinase (ERK 1/2) in the R6/2 mouse model of Huntington's disease after phosphodiesterase IV inhibition

Neurobiology of Disease, 2012
The mitogen-activated protein kinases (MAPKs) superfamily comprises three major signaling pathways: the extracellular signal-regulated protein kinases (ERKs), the c-Jun N-terminal kinases or stress-activated protein kinases (JNKs/SAPKs) and the p38 ...
Francesca R. Fusco +9 more
doaj

The role of cyclic nucleotide phosphodiesterases in the regulation of adipocyte lipolysis

Journal of Lipid Research, 2005
This study assessed the effects of selective inhibitors of 3′,5′-cyclic nucleotide phosphodiesterases (PDEs) on adipocyte lipolysis. IC224, a selective inhibitor of type 1 phosphodiesterase (PDE1), suppressed lipolysis in murine 3T3-L1 adipocytes (69.6 ±
Peter B. Snyder +4 more
doaj

El aumento del dolor inflamatoria producido por formalina es mediado por ampC: Efecto del Rolipram

Ecosistemas y Recursos Agropecuarios, 2014
En este trabajo se evaluó el efecto del rolipram, un inhibidor selectivo de la fosfodiesterasa 4, en el dolor inflamarotio producido por formalina en la rata.
Jorge Elias Torres - López, Vinicio Granados Soto +1 more
doaj +1 more source

Rolipram Inhibits Staphylococcal Enterotoxin B-Mediated Induction of the Human Skin-Homing Receptor on T Lymphocytes [PDF]

, 1999
Luis F. Santamaria‐Babí +6 more
openalex +1 more source

phosphodiesterase
biochemistry
enzyme

medicine
chemistry
internal medicine

pharmacology
male
biology