Results 81 to 90 of about 7,547 (235)
Inhibition of phosphodiesterases 1 and 4 prevents myofibroblast transformation in Peyronie's disease
BJU International, Volume 135, Issue 5, Page 810-817, May 2025.Objectives To investigate which phosphodiesterase (PDE) isoforms are expressed in fibroblasts isolated from the tunica albuginea (TA) of patients with Peyronie's disease (PD), and to measure the potency of PDE inhibitors in preventing transformation of these fibroblasts to profibrotic myofibroblasts.
Sophie L. Harding +4 more
wiley +1 more source
Inhibition of phosphodiesterase 4 reduces ethanol intake and preference in C57BL/6J mice
Frontiers in Neuroscience, 2014 Some anti-inflammatory medications reduce alcohol consumption in rodent models. Inhibition of phosphodiesterases (PDE) increases cAMP and reduces inflammatory signaling.
Yuri A. Blednov +3 more
doaj +1 more source
Protective Effect of Administered Rolipram against Radiation-Induced Testicular Injury in Mice
The World Journal of Men's Health, 2015 Purpose Pelvic irradiation for the treatment of cancer can affect normal cells, such as the rapidly proliferating spermatogenic cells of the testis, leading to infertility, a common post-irradiation problem.
Wan Lee +6 more
semanticscholar +1 more source
Rolipram und tageszeitliche Rhythmen an Ratten
, 2013 Die pharmakologische Wirkung von Rolipram, einem Phosphodiesterase 4 Hemmer, wird an männlichen WISTAR-Ratten mit einer Dosis von 2,5 mg/kg Körpergewicht untersucht. Der Versuchsablauf ist gekennzeichnet durch eine über insgesamt 24 Stunden in jeweils zweistündigem Abstand durchgeführte jeweils sechzigminütige Verhaltensbeobachtung, die unter einem 12 ...
openaire +1 more source
British Journal of Pharmacology, 2014 cAMP and pharmacological inhibition of PDE4, which degrades it, are promising therapeutic targets for the treatment of spinal cord injury (SCI). Using our previously described in vitro SCI model, we studied the mechanisms by which cAMP modulators promote
S D Boomkamp +3 more
semanticscholar +1 more source
Molecules, 2016 Uterine relaxation is crucial during preterm labor. Phosphodiesterase-4 (PDE-4) inhibitors have been proposed as tocolytics. Some thalidomide analogs are PDE-4 inhibitors.
Eduardo Fernández-Martínez +6 more
doaj +1 more source
Fear renewal activates cyclic adenosine monophosphate signaling in the dentate gyrus
Brain and Behavior, 2019 Background Fear renewal, the context‐specific relapse of a conditioned fear after extinction, is a widely pursued model of post‐traumatic stress disorder and phobias. However, its cellular and molecular mechanisms remain poorly understood.
Yan-Wei Shi +4 more
doaj +1 more source
Medical science monitor basic research, 2014 Background Phosphodiesterase (PDE) inhibitors in the central nervous system have been shown to stimulate neuronal functions and increase neurogenesis in Alzheimer disease (AD) patients.
F. Akar +6 more
semanticscholar +1 more source