Results 81 to 90 of about 11,777 (278)
British Journal of Pharmacology, Volume 182, Issue 5, Page 1236-1253, March 2025.Abstract Background and Purpose Acetylcholine plays a key role in striatal function. Firing properties of striatal cholinergic interneurons depend on intracellular cAMP through the regulation of Ih currents. Yet, the dynamics of cyclic nucleotide signalling in these neurons have remained elusive.
Ségolène Bompierre +7 more
wiley +1 more source
The PDE4 inhibitor rolipram reverses object memory impairment induced by acute tryptophan depletion in the rat [PDF]
, 2007 The selective type IV phosphodiesterase inhibitor, rolipram, has been shown to improve long-term memory and can reverse the cholinergic deficit caused by scopolamine. However, the underlying mechanisms of action of rolipram remain obscure.
A. Blokland +3 more
core +2 more sources
Chemistry – A European Journal, Volume 31, Issue 12, February 25, 2025.Photochemistry: A cheap, metal‐free, photochemical protocol for the 1,4‐decarboxylative addition between carboxylic acids and electron‐deficient olefins, under irradiation at 427 nm, utilizing the cheap, metal‐free, commercially available, thioxanthone or thioxanthone‐TfOH complex as the suitable photocatalyst.
Charikleia S. Batsika +2 more
wiley +1 more source
Frontiers in Cellular Neuroscience, 2016 Rett syndrome (RTT) patients experience learning difficulties and memory loss. Analogous deficits of hippocampal plasticity are reported in mouse models of RTT.
Saju Balakrishnan +2 more
semanticscholar +1 more source
Alzheimer's &Dementia, Volume 21, Issue 2, February 2025.Abstract INTRODUCTION Malnutrition correlates with neuropsychiatric symptoms (NPSs) in Alzheimer's disease (AD); however, the potential mechanism underlying this association remains unclear. METHODS Baseline and longitudinal associations of nutritional status with NPSs were analyzed in 374 patients on the AD continuum and 61 healthy controls.
Jiwei Jiang +15 more
wiley +1 more source
Effects of PDE4 Pathway Inhibition in Rat Experimental Stroke
Journal of Pharmacy & Pharmaceutical Sciences, 2014 PURPOSE: The first genomewide association study indicated that variations in the phosphodiesterase 4D (PDE4D) gene confer risk for ischemic stroke. However, inconsistencies among the studies designed to replicate the findings indicated the need for ...
Fan Yang +7 more
doaj +1 more source
Quantification of human brain PDE4 occupancy by GSK356278: A [11C](R)-rolipram PET study
Journal of Cerebral Blood Flow and Metabolism, 2017 We characterized the relationship between the plasma concentration of the phospodiesterase (PDE)-4 inhibitor GSK356278 and occupancy of the PDE4 enzyme in the brain of healthy volunteers, using the positron emission tomography (PET) tracer [11C](R ...
Jasper van der Aart +9 more
semanticscholar +1 more source
In vitro gametogenesis: Towards competent oocytes
BioEssays, Volume 47, Issue 1, January 2025.Functional gametes can be obtained by differentiation of pluripotent stem cells in culture. Here we review challenges faced by current approaches for obtaining developmentally competent oocytes from mouse embryonic and induced pluripotent stem cells.
Eishi Aizawa +2 more
wiley +1 more source
Mechanisms of cyclic nucleotide phosphodiesterases in modulating T cell responses in murine graft-versus-host disease. [PDF]
PLoS ONE, 2013 Graft-versus-host disease (GvHD) is a key contributor to the morbidity and mortality after allogeneic hematopoetic stem cell transplantation (HSCT). Regulatory Foxp3(+) CD4(+) T cells (Treg) suppress conventional T cell activation and can control GvHD ...
Michael Weber +8 more
doaj +1 more source