Results 181 to 190 of about 4,462 (291)

Macroscopic Convective Fluid Flows Arising From Binding of Ions and Small Molecules to Proteins

open access: yesSmall, EarlyView.
The interaction of ions or small molecules with proteins causes convective flows due to the displacement of water from the hydration shell. As shown, the replacement of the nickel ion removed from urease by EDTA pre‐treatment results in binding‐induced convective fluid flow.
Shanid Babu Shrestha   +4 more
wiley   +1 more source

Seismic evaluation of the southbound Stellenberg Interchange Bridge, B5593, in South Africa

open access: yesStructural Concrete, EarlyView.
Abstract This study presents a nonlinear finite element assessment of the seismic vulnerability of Bridge B5593, located in the south‐western region of South Africa. Previous evaluations identified a high likelihood of column failure; however, these were based on linear material models incapable of capturing damage evolution.
Wandie Olivier, Trevor Haas
wiley   +1 more source

Home foreclosure discounts in auctions without reserve prices

open access: yesReal Estate Economics, EarlyView.
Abstract This article estimates foreclosure discounts in Cape Town, South Africa, where, until 2019, foreclosure auctions occurred without reserve prices. Using newly constructed data linking sheriff auction notices to the universe of property transactions, rich property characteristics, and municipal service‐request records, I document large ...
Allan Davids
wiley   +1 more source

Renal‐vascular axis: unmasking its role in vascular endothelial growth factor‐inhibitor vascular toxicity in cancer patients

open access: yesBritish Journal of Pharmacology, EarlyView.
Abstract Vascular toxicity is a growing concern in cancer patients receiving vascular endothelial growth factor inhibitor (VEGFi) therapy, posing a significant threat to patient prognosis. While the primary mechanism of VEGFi‐induced vascular toxicity is linked to redox‐sensitive reactions that disrupt vascular tone, leading to hypertension and ...
Grace Whelan, Karla B. Neves
wiley   +1 more source

Progressively Projected Newton's Method

open access: yesComputer Graphics Forum, EarlyView.
Abstract Newton's Method is widely used to find the solution of complex non‐linear simulation problems. To guarantee a descent direction, it is common practice to clamp the negative eigenvalues of each element Hessian prior to assembly—a strategy known as Projected Newton (PN)—but this perturbation often hinders convergence.
J. A. Fernández‐Fernández   +2 more
wiley   +1 more source

Extreme weather and economic crisis in the 1430s in England, and the implications for tenurial change

open access: yesThe Economic History Review, EarlyView.
Abstract The 1430s were characterized by extreme weather conditions, food and fodder shortages, and high mortalities among animals and humans, although the severity of events and their consequences in England have received limited attention. The economic downturn and the depressed customary land market in this decade marked the beginning of the Great ...
Mark Bailey
wiley   +1 more source

ADAM17 and its proteolytic targets in disease pathogenesis

open access: yesThe FEBS Journal, EarlyView.
ADAM17 as a multifunctional sheddase with contrasting roles across inflammatory, metabolic, cardiovascular, and neoplastic diseases. Through regulated activation by iRhom, iTAP/FRMD8, and tetraspanins, ADAM17 cleaves diverse membrane ligands and receptors, thereby promoting inflammation, fibrosis, obesity, insulin resistance, and tumor progression ...
Abdulbasit Amin, Marina Badenes
wiley   +1 more source

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