Results 151 to 160 of about 2,422,126 (278)

Synergistic p53 Pathway Activation Through Sono‐Gene Therapy Induced by Ultrasound‐Triggered Theranostic Mesoporous Nanoparticles

open access: yesAdvanced Science, EarlyView.
Schematic representation of ultrasound‐mediated ICG/siCD24@MSN‐LCD from nanostructure to synergistic sono‐gene therapy. This nanoplatform targets ASGPR via the LCD shell, which dissociates to release loaded ICG and siCD24. The core mechanism involves ultrasound‐guided sonodynamic therapy by ICG and CD24 knockdown by siCD24, both activating the p53 axis
Yading Zhao   +11 more
wiley   +1 more source

Reversible Exfoliation‐Aggregation Dynamics in Ionic COFs for Tunable Interfacial Catalysis

open access: yesAdvanced Science, EarlyView.
A unique ionic covalent organic framework (I‐4) exhibits unprecedented concentration‐dependent dynamic behavior in water, undergoing reversible transitions between aggregation and exfoliation. This enables fully controllable, bidirectional modulation of its particle size and surface micro‐environment.
Jilu Yang   +8 more
wiley   +1 more source

3D Printed Meter‐Scale Soft Origami Robots Capable of Load‐Bearing Actuation Via Crease Stiffness Modulation

open access: yesAdvanced Science, EarlyView.
Origami has inspired numerous soft deployable mechanisms for safe human‐robot interaction, while its intrinsic kinematic instability at arbitrary configurations limited their practical robotic application. This work presents a 3D printed meter‐scale origami robotic actuator capable of load‐bearing deformation through creaseline stiffness modulation.
Sung Yol Yu   +5 more
wiley   +1 more source

Dual‐Organelle Secretome Conjugation and Organ‐Uptake Tracking (DuO‐SCOUT) Enables Deep and Sensitive Mapping of the Secreted Proteins

open access: yesAdvanced Science, EarlyView.
A novel dual‐organelle proximity labeling platform, DuO‐SCOUT, decodes the complex landscape of systemic organ‐organ communication by capturing both classical and unconventional secretomes. Application in metabolic models maps the adipose‐to‐brain secretory relay, identifying selective extra‐hypothalamic sites for adipose‐derived factors and expanding ...
Fenglian Yang   +7 more
wiley   +1 more source

Translational Barriers and AI‐Driven Challenges of Microfluidics‐Enabled Wearables and Implantable Systems in Personalized Medicine

open access: yesAdvanced Science, EarlyView.
An integrative review of microfluidics‐enabled wearables and implantable systems reveals a single‐track translation pipeline, bridging functional biomaterials with clinical utility. Dynamic feedback loops driven by artificial intelligence advance diagnostics toward personalized closed‐loop theranostics.
Ke Huang   +3 more
wiley   +1 more source

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