Results 81 to 90 of about 128,027 (302)

Advanced Experiment Design Strategies for Drug Development

open access: yesAdvanced Intelligent Discovery, EarlyView.
Wang et al. analyze 592 drug development studies published between 2020 and 2024 that applied design of experiments methodologies. The review surveys both classical and emerging approaches—including Bayesian optimization and active learning—and identifies a critical gap between advanced experimental strategies and their practical adoption in ...
Fanjin Wang   +3 more
wiley   +1 more source

New Insights Into Changes in the DNA Methylation Pattern of the SHOX Gene in Patients With Léri‐Weill Dyschondrosteosis

open access: yesAmerican Journal of Medical Genetics Part A, EarlyView.
ABSTRACT SHOX gene haploinsufficiency is associated with Léri‐Weill dyschondrosteosis (LWD) or idiopathic short stature (ISS) and could be caused by the structural and point mutations in the coding region and by the deletions in SHOX gene regulatory sequences. The role of the duplications in regulatory sequences is ambivalent.
Valeriia Kopytko   +3 more
wiley   +1 more source

On a Relation between the Perfect Roman Domination and Perfect Domination Numbers of a Tree

open access: yesMathematics, 2020
A dominating set in a graph G is a set of vertices S ⊆ V ( G ) such that any vertex of V − S is adjacent to at least one vertex of S .
Zehui Shao   +4 more
doaj   +1 more source

Total restrained Roman domination

open access: yes, 2022
Published by Azabaijan Shahid Madani University, Azarshahr ...
Amjadi, Jafar   +2 more
openaire   +3 more sources

Domination Across Borders: An Introduction [PDF]

open access: yes, 2015
This chapter explores the different dimensions of domination, including whether it has a structural approach, its relation to race and imperialism, and how non-domination can be institutionalized and achieved at a global ...
Buckinx, Barbara   +2 more
core  

Roman domination number on cardinal product of paths and cycles

open access: yesCroatian Operational Research Review, 2015
In this paper, the authors have determined certain upper and lower bounds for Roman domination numbers on cardinal products for any two graphs and some exact values for the cardinal product of paths and cycles.
Antoaneta Klobučar, Ivona Puljić
doaj   +1 more source

Total Perfect Roman Domination

open access: yesSymmetry, 2023
A total perfect Roman dominating function (TPRDF) on a graph G=(V,E) is a function f from V to {0,1,2} satisfying (i) every vertex v with f(v)=0 is a neighbor of exactly one vertex u with f(u)=2; in addition, (ii) the subgraph of G that is induced by the vertices with nonzero weight has no isolated vertex. The weight of a TPRDF f is ∑v∈Vf(v). The total
openaire   +1 more source

Dignidad personal y libertad: libertad y ciudadanía en la antigua Roma [PDF]

open access: yes, 2013
El artículo tiene por objeto el estudio de la ciudadanía en la Antigua Roma entendida como status de los civis romanos que les permitía el pleno ejercicio de los derechos políticos y civiles.
Blanch Nougués, José María
core   +1 more source

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