Results 141 to 150 of about 2,406,276 (362)
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Infrared nanoimaging of WTe2 at room temperature
四川大学学报. 自然科学版, 2019 We use scattering scanning near field optical microscopy to investigate the near field response of tungsten ditelluride(WTe2). By using finite-dipole model we calculate the scattered signal ratio of sample to substrate and found that it can not be fully ...
LUO Guo-Yu +5 more
doaj
Room Temperature InGaAs/AlGaAsSb Single Photon Avalanche Diode
IEEE Photonics JournalNear-infrared Single Photon Avalanche Diodes (SPADs) are the dominant, practical single photon detectors for quantum applications and low-level optical sensing.
J. Taylor-Mew +4 more
doaj +1 more source
Room-temperature polariton lasing in quantum heterostructure nanocavities
, 2018 Controlling light-matter interactions in solid-state systems has motivated intense research to produce bosonic quasi-particles known as exciton-polaritons, which requires strong coupling between excitons and cavity photons.
Chang-Hee Cho (1334178) +5 more
core +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Editorial: Metal-free room-temperature phosphorescence
Frontiers in Chemistry, 2022 Shuzo Hirata +3 more
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Hunting for room temperature superconductors
The Innovation MaterialsRoom temperature superconductivity, as one of the famous jewels on the crown of physics, has attracted continuous attention and unremitting efforts from numerous scientists. In recent years, more and more reports on room temperature superconductivity evoke many anticipations, but results remain controversial.
openaire +2 more sources
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Room Temperature Phosphorescent Nanofiber Membranes by Bio-fermentation
Stimuli-responsive materials exhibiting exceptional room temperature phosphorescence (RTP) hold promise for emerging technologies. However, constructing such systems in a sustainable, scalable, and processable manner remains challenging.
Zeyang, Ding +10 more
core +1 more source