Results 41 to 50 of about 30,905 (302)

Patient Falls in Seclusion Rooms in Psychiatric Inpatient Care

open access: yesJournal of Nursing Care Quality, 2022
Background: Patient falls are a major adverse event in psychiatric inpatient care. Purpose: To model the risk for patient falls in seclusion rooms in psychiatric inpatient care. Methods: Sociotechnical probabilistic risk assessment (ST ...
Varpula Jaakko   +3 more
openaire   +3 more sources

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

open access: yesFEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel   +13 more
wiley   +1 more source

Embedding information skills on student learning: providing the models [PDF]

open access: yes, 2007
This article was first published in the Wolverhampton Intellectual Repository and E-Theses (WIRE). There is no printed version.This Phase 3 (evaluation and embedding) project has been developed from a highly successful earlier project: Embedding ...
Bastable, Wendy, Morris, Pamela
core   +1 more source

Sensory integration rooms in care centers for autistic children

open access: yesMaǧallaẗ Al-Turāṯ wa Al-Taṣmīm, 2021
Autism is a very complex condition that affects every child differently, so the research deals with designing a room for sensory integration for children that mainly suffer from perceptual integration disorder in the internal space, whether it is a visual, auditory or sensory defect to create a safe environment that does not pose any threats in which ...
Shaima Mohammed Abdel-Hamid   +2 more
openaire   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

open access: yesMolecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice   +16 more
wiley   +1 more source

Putting Families First: How the Opioid Epidemic is Affecting Children and Families, and the Child Welfare Policy Options to Address It [PDF]

open access: yes, 2019
: Opioids and Child Welfare Across the country, placements in foster care are rising. In 2016, the U.S. Department of Health and Human Services reported that 273,539 children in the U.S. entered foster care.
American Academy of Pediatrics Council on Foster Care, Adoption, and Kinship Care   +3 more
core   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

A QUALITY IMPROVEMENT STUDY OF THE implimentation of the VERMONT NEWBORN PLAN OF SAFE CARE AMONG NURSING STAFF AT VERMONT HOSPITALS [PDF]

open access: yes, 2019
PURPOSE: The purpose of this quality improvement needs assessment was to evaluate the implementation of the Vermont Newborn Plan of Safe Care (VNPSC) since its introduction 17 months ago. These plans were created in response to federal mandates to create
Buley, Annik
core   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

open access: yesMolecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee   +8 more
wiley   +1 more source

Perception of the Mother- and Baby-Friendly Hospital Initiative (MBFHI) in Cartagena, Colombia, 2012

open access: yesRevista Ciencias de la Salud, 2015
Objective: To establish the perception level of the implementation of the BFHI initiative steps in health institutions in Cartagena in 2012. Material and methods: Descriptive study in a population constituted by 21 public and private institutions, as ...
Rossana López Sáleme   +5 more
doaj   +1 more source

Home - About - Disclaimer - Privacy