Results 51 to 60 of about 4,281 (248)

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Breast Feeding Initial Difficulties -descriptive study

Online Brazilian Journal of Nursing, 2006
This study aimed at identifying initial difficulties in breastfeeding in a rooming-in care. An assessment of ninety newly-born`sucking was carried out, using UNICEF standard protocol. Observation revealed that most mother-infant pairs presented favorable
Eunice Francisca Martins E. F. Martins, Cármem Mayana Bonfim Esteves Oliveira C. M. B. E Oliveira   +1 more
doaj  

Understanding Costs of Care in the Operating Room [PDF]

JAMA Surgery, 2018
Increasing value requires improving quality or decreasing costs. In surgery, estimates for the cost of 1 minute of operating room (OR) time vary widely. No benchmark exists for the cost of OR time, nor has there been a comprehensive assessment of what contributes to OR cost.To calculate the cost of 1 minute of OR time, assess cost by setting and ...
Christopher P, Childers, Melinda, Maggard-Gibbons   +1 more
openaire   +2 more sources

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Breastfeeding: providing care in rooming-in care

Rev Rene, 2013
The study aims to verify the performance of nursing team, with the mothers, before the process of breastfeeding and prevention of breastfeeding problems, in the rooming in a reference maternity hospital, in the city of Juazeiro do Norte, CE, Brazil. Descriptive study with qualitative approach in which respondents were eight professionals of the nursing
Saraiva, Ana Raquel, Carvalho, Amanda Cordeiro, Gonçalves, Gleice Adriana, Soares, Jaqueliny Rodrigues, Pinto, Sarah Lima   +4 more
openaire   +3 more sources

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Implementation of shared decision-making about rooming-in: A before and after an audit of breastfeeding in Taiwan

International Breastfeeding Journal
Background The 24-h rooming-in policy is crucial to the Baby-Friendly Hospital Initiative (BFHI) for promoting breastfeeding. However, this policy may restrict maternal autonomy.
Hsiao-Ying Hung, Chun-Che Wen, Pei-Fang Su, Shek-Yip Man, Ying-Ju Chang   +4 more
doaj   +1 more source

NEW MOTHERS’ KNOWLEDGE ABOUT HYGIENE FOR NEW-BORNS

Cogitare Enfermagem, 2012
This descriptive, transversal study aimed to evaluate mothers’ knowledge about measures of hygiene applied to new-borns. It was carried out with 150 women who had recently given birth in a maternity ward in the city of Fortaleza in the state of Ceará ...
Lucilande Cordeiro de Oliveira Andrade, Marcos Silva dos Santos, Julliana dos Santos Aires, Emanuella Silva Joventino, Regina Cláudia Melo Dodt, Lorena Barbosa Ximenes   +5 more
doaj   +1 more source

A Playroom Internal Waiting Area Improves Productivity in the Pediatric Emergency Department

Western Journal of Emergency Medicine, 2020
Introduction: Pediatric emergency department (PED) volume is often constrained by the number of available treatment rooms. In many PEDs patients occupy treatment rooms while awaiting test results or imaging, thereby delaying care for patients who arrive ...
Paul Walsh, Jennifer Denno
doaj   +1 more source