Results 51 to 60 of about 296,851 (313)

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

open access: yesMolecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley   +5 more
wiley   +1 more source

Prevalencia del Síndrome de Desgaste Laboral en Residentes del Hospital Roosevelt y Hospital General San Juan de Dios en el año 2015

open access: yesRevista de la Facultad de Medicina, 2016
Contexto: El Síndrome de Desgaste Laboral es un padecimiento que consiste en una respuesta prolongada de estrés en el organismo ante los factores estresantes emocionales e interpersonales que se presentan en el trabajo, que incluye: fatiga crónica ...
Natalia Ybarra   +2 more
doaj   +1 more source

Four Freedoms Park in Roosevelt Island, New York City [PDF]

open access: yes, 2018
Il Memoriale delle Quattro Libertà è stato progettato nel 1973-1974 dall'architetto statunitense di origine lettone, Louis I. Kahn per la punta meridionale dell'isola Roosevelt a New York City, e fa parte di un parco commemorativo a Franklin D. Roosevelt.
Scatena, Donatella
core  

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns   +10 more
wiley   +1 more source

Entre ciência e aventura: considerações em torno da Expedição Roosevelt-Rondon

open access: yesFronteiras, 2016
O presente texto procura fazer um balanço dos resultados da Expedição Roosevelt-Rondon, a propósito do seu centenário lembrado recentemente. Evidencia que Roosevelt oscila entre ideias de preservação e o prazer das caçadas, apontando, também,
João Klug
doaj  

“Tuvimos que permanecer neutrales”: los Roosevelt y la cuestión de la ayuda a la República española durante la Guerra Civil (1936-1939)

open access: yesCuadernos de Historia de España
Este artículo analiza qué tipo de ayuda brindaron Franklin D. Roosevelt y Eleanor Roosevelt a la población civil y al Gobierno republicano durante la Guerra Civil española (1936 -1939), teniendo en cuenta la decisión que había tomado el Gobierno ...
María Luz Arroyo Vázquez
doaj   +1 more source

The War on Terror is Over--Now What? Restoring the Four Freedoms as a Foundation for Peace and Security [PDF]

open access: yes, 2009
This article observes that the Global War on Terror as an organizing concept has been abandoned and proposes that the Obama Administration restore FDR\u27s Four Freedoms in its ...
Shulman, Mark R.
core   +1 more source

The Legislative Veto: Invalidated, It Survives [PDF]

open access: yes, 1993
The Supreme Court\u27s decision in INS vs Chadha is examined, and the origins of the legislative veto and its traditional place in the lawmaking process is ...
Fisher, Louis
core   +2 more sources

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

open access: yesMolecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel   +6 more
wiley   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

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