Results 61 to 70 of about 83,746 (304)
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Informative insights into the making of a president
Pacific Journalism Review, 2009 The Making of FDR argues that the image of US President Franklin Delano Roosevelt as a modern, charismatic, and politically astute leader was 'made' in a significant way by his talented but non-intellectual press secretary, Stephen Early.
Richard Shafer
doaj +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Revista de la Facultad de Medicina, 2016 Contexto: El Síndrome de Desgaste Laboral es un padecimiento que consiste en una respuesta prolongada de estrés en el organismo ante los factores estresantes emocionales e interpersonales que se presentan en el trabajo, que incluye: fatiga crónica ...
Natalia Ybarra +2 more
doaj +1 more source
Postcard, Cresot plant, Roosevelt
, 1937 Postcard reads: P 1627 Cresot Plant, Roosevelt, N ...
core +1 more source
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
Cuadernos de Historia de EspañaEste artículo analiza qué tipo de ayuda brindaron Franklin D. Roosevelt y Eleanor Roosevelt a la población civil y al Gobierno republicano durante la Guerra Civil española (1936 -1939), teniendo en cuenta la decisión que había tomado el Gobierno ...
María Luz Arroyo Vázquez
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Espacio, Tiempo y Forma. Serie V, Historia Contemporánea, 1991 En apariencia la cuestión referente a las relaciones entre FDR y Franco puede ser resuelta de una manera muy simple: sus ideales políticos eran radicalmente antitéticos, incluso en cierta manera más antitéticos que los de Rooseveit y Mussolini, por ...
Javier Tusell Gómez
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John F. Kennedy telegram to Roosevelt
, 1961 Jersey Homesteads (later the Borough of Roosevelt) was established in the 1930s as an agro-industrial cooperative community. It was established specifically for urban Jewish garment workers, many of whom had emigrated from Europe.
Kennedy, John F.
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Molecular Oncology, EarlyView.This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic +10 more
wiley +1 more source