Results 81 to 90 of about 298,662 (304)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

Great Leaders Fight for the Right Cause at the Wrong Time [PDF]

open access: yes, 2014
Emilio Iodice examines a wealth of historical figures with the primary object of demonstrating how passion, commitment, and accountability are infused in the sayings and actions of great men and women; it is through their courage and sacrifice that we ...
Iodice, Emilio F.
core   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

open access: yesFEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin   +3 more
wiley   +1 more source

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

open access: yesFEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata   +13 more
wiley   +1 more source

Logan, Anne, 1921-2008 (SC 1637) [PDF]

open access: yes, 2008
Finding aid and scan (Click on Additional Files below) for Manuscripts Small Collection 1637. Letter from Anne Logan, a U.S. Army sergeant serving in Frankfurt, Germany, to her family detailing a furlough to London during which time she was entertained
Folklife Archives, Manuscripts &
core   +1 more source

Shared Genetic Effects and Antagonistic Pleiotropy Between Multiple Sclerosis and Common Cancers

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Epidemiologic studies have reported inconsistent altered cancer risk in individuals with multiple sclerosis (MS). Factors such as immune dysregulation, comorbidities, and disease‐modifying therapies may contribute to this variability.
Asli Buyukkurt   +5 more
wiley   +1 more source

Hinsdale Rally Speech [PDF]

open access: yes, 1984
Speech for campaign rally at the Central High School, Hinsdale, IL, October, 12, 1984. Includes handwritten notes and diacritic marks.https://ir.lawnet.fordham.edu/vice_presidential_campaign_speeches_1984/1045/thumbnail ...
Ferraro, Geraldine
core   +1 more source

Unraveling the Molecular Mechanisms of Glioma Recurrence: A Study Integrating Single‐Cell and Spatial Transcriptomics

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Glioma recurrence severely impacts patient prognosis, with current treatments showing limited efficacy. Traditional methods struggle to analyze recurrence mechanisms due to challenges in assessing tumor heterogeneity, spatial dynamics, and gene networks.
Lei Qiu   +10 more
wiley   +1 more source

Revolutionary Central Europe: Diary of an American in 1919

open access: yesAmerican Studies in Scandinavia, 2020
Nicholas Roosevelt, journalist and diplomat, served during the Paris Peace Conference as a member of the Coolidge mission, which had Vienna as its seat and gathered information about Austria and the other countries in the neighborhood.
Zoltán Peterecz
doaj  

Seeking comradeship in the "Ogre's Den:" Winston Churchill's quest for a warrior alliance and his mission to Stalin, August 1942 [PDF]

open access: yes, 2007
On 12 August 1942, British Prime Minister Winston Churchill arrived in Moscow to meet Soviet leader Josef Stalin, for the first time, a mission that Churchill’s wife, Clementine, had described to him as a “visit to the Ogre in his Den.” Churchill had, by
Folly, MH
core  

Home - About - Disclaimer - Privacy