Results 101 to 110 of about 298,662 (304)

Baseline Regional Cholinergic Denervation Predicts Cognitive Trajectories in Moderate Parkinson Disease

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Cognitive decline is a disabling and variable feature of Parkinson disease (PD). While cholinergic system degeneration is linked to cognitive impairments in PD, most prior research reported cross‐sectional associations. We aimed to fill this gap by investigating whether baseline regional cerebral vesicular acetylcholine transporter ...
Taylor Brown   +6 more
wiley   +1 more source

LOSING BATTLES AND WINNING WARS: FRANKLIN ROOSEVELT AND THE FIGHT TO TRANSFORM THE SUPREME COURT, 1937 - 1941

open access: yesEssays in Economic and Business History, 1999
This paper examines the dramatic rise of the Roosevelt Court between the years 1937 and 1941. Having gone through his first term of office without a single Supreme Court appointment, Franklin Roosevelt was to be given the opportunity during his second ...
Harvey Hudspeth
doaj  

Ketogenic Diet as an Epigenetic Therapy in SETD1B‐Related Epilepsy

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Histone lysine methyltransferases such as SETD1B regulate chromatin structure and gene transcription. Ketone bodies, including butyrate, act as histone deacetylase inhibitors. We report a 4‐year‐old boy with SETD1B‐related absence epilepsy, refractory to conventional medications, who achieved sustained > 90% seizure reduction on the Modified ...
Erica Tsang   +10 more
wiley   +1 more source

Multidimensional Profiling of MRI‐Negative Temporal Lobe Epilepsy Uncovers Distinct Phenotypes

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Although hippocampal sclerosis (TLE‐HS) represents the most frequent cause of temporal lobe epilepsy (TLE), up to 30% of patients show no lesion on visual MRI inspection (TLE‐MRIneg). These cases pose diagnostic and therapeutic challenges and are underrepresented in surgical series.
Alice Ballerini   +28 more
wiley   +1 more source

THE BEST LAID PLANS: FRED M. VINSON AND THE DECLINE AND FALL OF THE ROOSEVELT COURT, 1946-1949

open access: yesEssays in Economic and Business History, 2001
One of the great ironies in constitutional history is the fact that the Supreme Court that Franklin Roosevelt labored so hard to construct lasted for such a short period of time following his death.
Harvey Hudspeth
doaj  

Normal‐Appearing White Matter Injury Mediates Chronic Deep Venous Hypoxia and Disease Progression in Multiple Sclerosis

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore how cerebral hypoxia and Normal‐Appearing White Matter (NAWM) integrity affect MS lesion burden and clinical course. Methods Seventy‐nine MS patients, including 13 clinically isolated syndrome (CIS) patients and 66 relapsing–remitting multiple sclerosis (RRMS) patients, and 44 healthy controls (HCs) were recruited from ...
Xinli Wang   +8 more
wiley   +1 more source

Students at New York Life Revitalizing High School Libraries Sites Talk About Why Their Library Media Centers Rock! [PDF]

open access: yes, 2006
Funded by the New York Life Foundation from 2003-2005, Revitalizing High School Libraries (RHSL) was a pilot program that allowed Public Education Network (PEN) and its member local education funds (LEFs) in Minneapolis, San Francisco and Tampa to update

core  

CSF Monoamine Metabolites and Cognitive Trajectory in Early Parkinson's Disease

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Imaging and postmortem studies indicate that abnormalities in monoaminergic neurotransmission contribute to cognitive impairment in Parkinson's disease (PD). However, it remains uncertain if cerebrospinal fluid (CSF) monoamine metabolites can serve as biomarkers of cognitive decline in early PD.
Jing‐Yu Shao   +7 more
wiley   +1 more source

The Battle FDR Lost:The Failed Nomination of Boss Ed Flynn as Minister to Australia

open access: yes, 2018
Shortly after Christmas in 1942, the U.S. minister to Australia, Nelson Trusler Johnson, decided the time was right for a break from his wartime duties.
Birkner, Michael J.
core  

The Tolstoy-Dolan Mission and the Establishment of US-Tibetan Relations: An investigation into the events that unfolded after the first visit of American representatives to Lhasa in 1943 [PDF]

open access: yes, 2017
This article investigates the events that unfolded during and after the visit of two Office of Strategic Service (OSS) agents to Lhasa in spring 1943.
Ernst, Maximilian
core  

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