Results 131 to 140 of about 391,360 (247)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Root Cause Analysis for Outbreaks of Carbapenem-Resistant <i>Acinetobacter baumannii</i> and <i>Pseudomonas aeruginosa</i> in a Pediatric Intensive Care Unit: A Retrospective Study. [PDF]

Infect Drug Resist
Peng W, Hao Y, Ding H, Wang Z, Tan K, Tan L.   +5 more
europepmc   +1 more source

Proactive method for identification and handling of patient complaints with root cause analysis in Surabaya Islamic Hospital. [PDF]

J Public Health Res, 2023
Aan Adriansyah A, Setianto B, Lukiyono YT, Wikurendra EA.   +3 more
europepmc   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Root cause analysis of accidents and examining their interrelations from the perspective of workers, supervisors, and safety officers. [PDF]

PLoS One
Molamehdizadeh N, Halvani GH, Ebrahimi H, Farshad AA, Kharghani Moghadam SM, Eskandari T.   +5 more
europepmc   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Cloned Journals: Root Cause Analysis and Way Forward

Journal of Marine Medical Society
Krishnan Shanmuganandan
doaj   +1 more source

Enhancing insulin administration safety in inpatient care: findings from a root cause analysis and continuous improvement intervention. [PDF]

Open Med (Wars)
Wang Q, Ma Y, Li M, Song J, Ma H.
europepmc   +1 more source

Team experiences of the root cause analysis process after a sentinel event: a qualitative case study. [PDF]

BMC Health Serv Res, 2023
Liepelt S, Sundal H, Kirchhoff R.
europepmc   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source