Results 141 to 150 of about 389,388 (249)

Monitoring and Root Cause Analysis of Clinical Biochemistry Turnaround Time at a Tertiary Care Institute. [PDF]

Cureus, 2023
Prasad P, Kumar R, Kumar S, Sinha P.
europepmc   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Root Cause Analysis of Omissions and Delays in the Initiation of Neoadjuvant Chemotherapy in Eligible Patients with Breast Cancer in British Columbia, Canada. [PDF]

Curr Oncol
Chan JLH, Lee JJ, Ohm H, Isaac KV, Nichol A.   +4 more
europepmc   +1 more source

Optimizing Sterilization Packaging through Root Cause Analysis: An Exploration into Sealing Defects of Paper-Plastic Pouches. [PDF]

Med Sci Monit, 2023
Jiang S, Yi L, Chen Y, Hu R.
europepmc   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Insights from a measles outbreak root cause analysis in Ethiopia - 2024. [PDF]

Pan Afr Med J
Alemu MA, Dema ST, Anteneh HA, Guade HT, Gebrekidan AH, Mersha AM, Lakew GA, Tufa YA, Shibeshi EZ, Nibzane GT, Hailemariam FT, Kita YG, Yimam F, Ayana WB, Hailekiros T, Amene K, Atakilti R, Alemu E, Yeshaw O, Malumo S, Kokebe MA, Getaneh MW, Afele MA, Masresha BG.   +23 more
europepmc   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Root causes and fields of action to address unplanned hospitalisation in long-term care: a multiple case study with root-cause analysis. [PDF]

BMC Nurs
Pohontsch NJ, Huckle TA, Jarchow AM, Balzer K, Silies KT.   +4 more
europepmc   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Root cause analysis investigation of visible particulates in therapeutic protein drug products using morphologically directed Raman spectroscopy. [PDF]

Sci Rep
de Luna IF, Telikepalli SN, Carrier M, Ripple D, Srinivasan C, O'Connor T, Lute S, Bhirde A.   +7 more
europepmc   +1 more source