Results 91 to 100 of about 52,887 (307)

GATA4‐Driven Transcription of HtrA1 Promotes Cellular Senescence in Ménière's Disease and Age‐Related Audio‐Vestibular Dysfunction

Advanced Science, EarlyView.
This study identifies the HDAC6/GATA4/HtrA1 axis as a critical driver of cellular senescence in the inner ear. GATA4 nuclear translocation, facilitated by HDAC6 downregulation, transcriptionally activates HtrA1, promoting hair cell senescence, SASP, and audio‐vestibular dysfunction in models of Ménière's disease and age‐related audio‐vestibular ...
Na Zhang, Na Li, Yan Wang, Jing Zhang, Jiahui Liu, Lei Chen, Yongdong Song, Yurong Mu, Yuechen Han, Yafeng Lyu, Xiaofei Li, Hanyue Wang, Jing Wang, Yao Lu, Zhaomin Fan, Daogong Zhang, Haibo Wang   +16 more
wiley   +1 more source

Root canal morphology of permanent mandibular incisors of Saudi subpopulation in Al-Baha region: A cone-beam computed tomography study

Saudi Endodontic Journal
Introduction: A proper understanding of root canal morphology and its deviations is essential for improving the outcomes of endodontic procedures. Therefore, the current study aims to explore the root canal morphology of permanent mandibular central and ...
Mohammed S. Alzahrani, Abdullah A. Alzahrani, Alaa M. Alghamdi, Abdulaziz Alghamdi, Hamod Alqahtani, Amal Ahmed Alzahrani, Manikandan Ravinanthanan, Khalid Lafi Alrashedi   +7 more
doaj   +1 more source

Root canal morphology of primary molars by clearing technique: An in vitro study

Journal of Indian Society of Pedodontics and Preventive Dentistry, 2018
Objective: The objective of the study was to study root canal morphology of primary molars by clearing technique and to observe for any variations. Materials and Methods: One hundred and twenty extracted primary molars were divided into four groups (n ...
Farhin Katge, Mayur Manohar Wakpanjar
doaj   +1 more source

Conformable Microelectrode Arrays Integrated with a Scoop‐Shaped Slide‐Well for Dynamic Electrophysiological Profiling of Patient‐Derived Cardiac Organoids

Advanced Science, EarlyView.
A flexible, ultrathin multi‐channel microelectrode array (MEA) conformally integrated onto a curved slide‐well enables stable electrical interfacing with 3D cardiac organoids. The geometry‐guided self‐alignment allows simultaneous recording of extracellular field potentials and contractile motion from irregular, beating tissues.
Ye Seul Kim, Jeonghwa Jeong, Gyeonghwa Heo, Young Woo Kwon, Jeongha Lee, Yoon Ji Jeong, Gyu Tae Park, Seongdo Jeong, Ki Won Hwang, Murim Choi, Jinhong Shin, Suck Won Hong, Jae Ho Kim   +12 more
wiley   +1 more source

Evaluation of root canal morphology of maxillary second premolars in a Saudi Arabian sub-population: An in vitro microcomputed tomography study

Saudi Dental Journal, 2016
Aim: To investigate the root canal morphology of maxillary second premolars in a Saudi Arabian subpopulation using microcomputed tomography (micro-CT). Methodology: Micro-CT analysis was performed on 100 maxillary second premolars.
Mutasim Elnour, Abdul Khabeer, Emad AlShwaimi   +2 more
doaj   +1 more source

Change in Working Length at Different Stages of Instrumentation as a Function of Canal Curvature [PDF]

, 2018
The aim of this study was to determine the change in working length (∆WL) before and after coronal flaring and after complete rotary instrumentation as a function of canal curvature.
Tang, Mei
core   +1 more source

Gut Mycobiota‐Associated Tryptophan Catabolites Protect Against Metabolic Dysfunction‐Associated Steatotic Liver Disease

Advanced Science, EarlyView.
ABSTRACT Accumulating evidence suggests that the intestinal microbiota participates in the progression of metabolic dysfunction‐associated steatotic liver disease (MASLD) through microbiota‐host interaction. However, the beneficial role of commensal mycobiota in MASLD progression remains poorly understood.
Shuping Qiao, Shuangya Fan, Juan Xu, Zhen Xu, Chen Peng, Junxing Qu, Ziqian Bing, Shizhen Zhou, Sunan Shen, Guifang Xu, Yue Zhao, Tingting Wang   +11 more
wiley   +1 more source

New specimens of the basal ornithischian dinosaur Lesothosaurus diagnosticus Galton, 1978 from the Early Jurassic of South Africa [PDF]

, 2016
We describe new specimens of the basal ornithischian dinosaur Lesothosaurus diagnosticus Galton, 1978 collected from a bonebed in the Fouriesburg district of the Free State, South Africa.
Baron, MG, Barrett, PM, Butler, RJ, Choiniere, JN, Yates, AM   +4 more
core   +2 more sources

A 3D In Vitro Model of the Human Hepatobiliary Junction

Advanced Science, EarlyView.
A 3D human organoid platform reconstructs the hepatobiliary junction between primary adult hepatocytes and intrahepatic cholangiocytes. These adult hepatobiliary organoids (aHBOs) support directional bile transport from canaliculi to ductule‐like structures, enable quantitative imaging of junction dynamics, and reveal cell‐type‐specific vulnerabilities
Ashley D. Westerfield, Katarzyna A. Grzelak, Katie Katsuyama, Vardhman Kumar, Bess M. Miller, Joa Yun, Jesse Kirkpatrick, David Mankus, Margaret E. Bisher, Abigail K.R. Lytton‐Jean, Z. Gordon Jiang, David D. Lee, Christopher S. Chen, Sangeeta N. Bhatia   +13 more
wiley   +1 more source

Evaluation of root canal morphology of mandibular premolars in a Saudi population using cone beam computed tomography: A retrospective study

Saudi Dental Journal, 2019
Objective: To investigate the root canal morphology of mandibular first and second premolars using Cone-Beam Computed Tomography (CBCT) in a Saudi population.
Hussam Alfawaz, Abdullah Alqedairi, Yousef Hamad Al-Dahman, Asma Suliman Al-Jebaly, Faisal Abdullah Alnassar, Sara Alsubait, Ziyad Allahem   +6 more
doaj   +1 more source