Results 111 to 120 of about 142,765 (282)

Leveraging Artificial Intelligence and Large Language Models for Cancer Immunotherapy

Advanced Science, EarlyView.
Cancer immunotherapy faces challenges in predicting treatment responses and understanding resistance mechanisms. Artificial intelligence (AI) and machine learning (ML) offer powerful solutions for cancer immunotherapy in patient stratification, biomarker discovery, treatment strategy optimization, and foundation model development.
Xinchao Wu, Mengtao Sun, Lusheng Li, Jieqiong Wang, Shibiao Wan   +4 more
wiley   +1 more source

Evaluation of root canal morphology of maxillary second premolars in a Saudi Arabian sub-population: An in vitro microcomputed tomography study

Saudi Dental Journal, 2016
Aim: To investigate the root canal morphology of maxillary second premolars in a Saudi Arabian subpopulation using microcomputed tomography (micro-CT). Methodology: Micro-CT analysis was performed on 100 maxillary second premolars.
Mutasim Elnour, Abdul Khabeer, Emad AlShwaimi   +2 more
doaj   +1 more source

Evaluation of Root and Root Canal Morphology of Mandibular First and Second Molars in a Greek Population: A CBCT Study

European Endodontic Journal, 2019
Objective: Τo study the number of roots, canal configurations, and frequency of morphological variations in mandibular first and second molars in a Greek population.
Eleni Kantilieraki, A. Delantoni, C. Angelopoulos, P. Beltes   +3 more
semanticscholar   +1 more source

Transferable Deep Reinforcement Learning With Edge‐Contour‐Depth Fusion for Autonomous Wireless Capsule Endoscopy Navigation

Advanced Science, EarlyView.
This study presents an anatomical landmark‐guided DRL framework for autonomous wireless capsule endoscopy navigation. Using a lightweight edge‐contour‐depth fusion module, it achieves over 97% coverage across diverse gastric anatomies. To ensure reliability, a two‐stage sim‐to‐real pipeline with an adaptive dynamic programming controller mitigates ...
Haoxuan Wu, Haitao Gao, Qingyang Liu, Sishen Yuan, Haiyang Fang, Mingwu Su, Baijia Liang, Yongzun Yang, Long Bai, Wenzhen Dong, Dihong Xie, Shijian Su, Jiewen Lai, Shing Shin Cheng, Zhen Li, Xiuli Zuo, Hongliang Ren   +16 more
wiley   +1 more source

Tumor‐Induced Splenic Remodeling: Mechanisms of Systemic Immunosuppression and Emerging Therapeutic Opportunities

Advanced Science, EarlyView.
ABSTRACT Despite the transformative impact of cancer immunotherapies such as immune checkpoint blockade, durable clinical responses remain limited. Increasing evidence indicates that antitumor immunity is governed not only by the tumor microenvironment, but also by systemic immune regulation mediated by peripheral immune organs. Among these, the spleen
Yuehua Liu, Xiaoqian Nie, Xiaofei Gao
wiley   +1 more source

A study of the symmetry of roots and root canal morphology in mandibular anterior teeth using cone-beam computed tomographic imaging in a Polish population.

Folia Morphologica, 2019
BACKGROUND The purpose of the study was to analyze mandibular anterior teeth in a Polish population and determine the symmetry of root and root canal morphology between the right and left side using cone-beam computed tomography scanning. MATERIALS AND
Magdalena Sroczyk-Jaszczyńska, Janusz Kołecki, M. Lipski, Michał Puciło, G. Wilk, A. Falkowski, K. Kot, A. Nowicka   +7 more
semanticscholar   +1 more source

Root canal morphology. Endodontic access

, 2019
The training manual is developed in full accordance with the training program for doctors - dentists. The manual presents classifications of the types of root canal structure, features morphology of root canals in various groups of teeth, principles of creating endodontic access, classification of tools for creating access and principles of their ...
Anna Yepishova, Andrey Chagay, Nina Chernyshova, Dina Sorokoumova, Sergey Griroriev   +4 more
openaire   +2 more sources

Mechanisms of Pericyte‐Mediated Cancer Metastasis

Advanced Science, EarlyView.
Pericytes play multifarious roles in promoting cancer metastasis by facilitating metastatic cancer cell dissemination, circulating tumor cell survival, tissue extravasation, premetastatic niche formation, and metastatic tumor growth. These cells have intertwined interactions with vascular endothelial cells to modulate cancer cell behavior and ...
Ziheng Guo, Yihai Cao
wiley   +1 more source

Evaluate root and canal morphology of primary mandibular second molars in Chinese individuals by using cone-beam computed tomography

Journal of the Formosan Medical Association, 2013
More detailed knowledge of root and canal morphology is important in order to improve the success in the endodontics of primary teeth. The purpose of this study was to evaluate the root and canal morphology of primary mandibular second molars (PMSMs) in ...
Ran Yang, Chan Yang, Yuan Liu, Yong Hu, Jing Zou   +4 more
doaj   +1 more source

ACLY‐Driven Metabolic Reprogramming Promotes Histone Acetylation and Inflammation‐Associated Fibrosis in Chronic Kidney Disease

Advanced Science, EarlyView.
This study reveals a citrate–ACLY–H3K27ac metabolic–epigenetic axis driving inflammatory gene activation and kidney fibrosis, highlighting ACLY inhibition as a potential therapeutic strategy for chronic kidney disease (CKD). ABSTRACT The mechanisms by which metabolic stress drives epigenetic dysregulation and fibrosis in chronic kidney disease (CKD ...
Chunxiu Du, Dhanunjay Mukhi, Lingzhi Li, Chenyu Li, Siyu Pan, Bernhard Dumoulin, Eunji Ha, Lakshmi P Kolligundla, Yanjuan Hou, Jonathan Levinsohn, Chaelin Kang, Konstantin Adrian Klötzer, Junnan Wu, Samer Mohandes, Kathryn E Wellen, Katalin Susztak   +15 more
wiley   +1 more source