Results 151 to 160 of about 2,588,760 (308)

FAK Mediated Coordination of Extracellular Matrix Remodeling and Cellular Mechanics Impairs Nanomedicine Delivery in Solid Tumors

Advanced Science, EarlyView.
FAK orchestrates a mechanical barrier limiting nanomedicine accumulation in solid tumors by coupling ECM remodeling with cytoskeletal tension. Genetic or pharmacological FAK inhibition dismantles this barrier, enhances clathrin‐mediated uptake and penetration, and overcomes delivery limitations to improve antitumor efficacy.
Tian Zhao, Hao Wu, Yujie Qin, Jingfei Zhu, Ye Huang, Wei Chen, Jiaxuan Yu, Xiang Qin, Shun Li, Junjie Li, Tingting Li, Yiyao Liu   +11 more
wiley   +1 more source

CBCT in Evaluation of Root Canal Preparation-A Scoping Review. [PDF]

Dent J (Basel)
Vidal A, Teles AM, Cardoso M, Bartolomeu M, Noites R.   +4 more
europepmc   +1 more source

Comparative evaluation of apical debris extrusion during root canal preparation using three different rotary file systems. [PDF]

F1000Res, 2023
Rajnekar R, Mankar N, Nikhade P, Chandak M.   +3 more
europepmc   +1 more source

CausalCellInfer: Prioritizing Cell‐Type‐Specific Disease Associations From Genetically Predicted Transcriptomes in Biobank Cohorts

Advanced Science, EarlyView.
Bulk and genotype‐imputed transcriptomes obscure the cellular drivers of complex disease. CausalCellInfer resolves them by integrating invariant marker selection, deep learning deconvolution, and regularized matrix completion. Applied to ∼500 000 UK Biobank participants across 29 traits, it uncovers hallmark cell‐type proportion shifts, including ...
Liangying Yin, Yujia Shi, Ruoyu Zhang, Yong Xiang, Jinghong Qiu, Pak‐Chung Sham, Hon‐Cheong So   +6 more
wiley   +1 more source

Effects of Three Different Niti Rotary Instruments on Dentin Cracks After Root Canal Preparation. [PDF]

J Dent Res Dent Clin Dent Prospects
Untari RM, Hadriyanto W, Sriwijaya R, Rinastiti M.   +3 more
europepmc   +1 more source

NCLX Inhibition plus Ca2+ Delivery Potentiates Electroporation and Antitumor Immunity in Pancreatic Ductal Adenocarcinoma

Advanced Science, EarlyView.
Electroporation combined with NCLX inhibition and Ca2+ delivery induces mitochondrial Ca2+ overload in PDAC cells, triggering pyroptosis, DAMP release, and antitumor immune activation. Simultaneously, suppression of tumor‐derived SPP1 weakens SPP1–CD44 signaling and remodels macrophages toward an antitumor phenotype, thereby enhancing CD8+ T‐cell ...
Chuanbing Zhao, Long He, Yu Lu, Zanglong Deng, Hongzhen Wei, Yunpeng Zhang, Ming Yang, Tao Yin   +7 more
wiley   +1 more source

Clinical Surface Alteration of Reciprocating Nickel-Titanium Instruments Following Root Canal Preparation and Sterilization: A Three-Dimensional FE-SEM-Based Analysis. [PDF]

Int J Dent
Huynh NH, Le HH, Tran NM, Le HV, Bui HA, Huynh TT, Le HL, Phan PD, Le NT, Tran TL, Pham TK, Nguyen CM, Bui HT, Tran TB, Lam QV, Lam QA, Lam DP, Nguyen TN, Nguyen TT, Pham TH, Do GK, Pham VK, Pham TL, Pham AT.   +23 more
europepmc   +1 more source

Dentinal Microcracks after Root Canal Preparation in Primary Root: An In Vitro Evaluation of ProTaper Gold and Kedo-S Rotary File Systems. [PDF]

Int J Clin Pediatr Dent, 2023
Patil MB, Mandroli PS, Jalannavar P, Patil BB.   +3 more
europepmc   +1 more source

The Characteristics of Tumor Microenvironment by the Single Cell Profile in Endometrial Cancer of no Specific Molecular Profile (NSMP) Subtype

Advanced Science, EarlyView.
A subset of tumor‐associated macrophages (TAMs) characterized by SPP1 expression is discovered, which may remodel the tumor microenvironment by potentially promoting CD4+ T cell stress and maintaining epithelial cell stemness through SPP1‐CD44, thereby potentially contributing to the proliferation and migration of tumor cells, which has been verified ...
Xinhui Yuan, Zhengyao Zhai, Chuyu Jing, Wei Zhang, Wenjuan Tian, Yulan Ren   +5 more
wiley   +1 more source

Influence of kinematic motion and instrumentation strategy on apical debris extrusion during root canal preparation: An <i>in vitro</i> study. [PDF]

J Conserv Dent Endod
Alghazaly A, Aljohani J, Mohabat K, Ghous R.   +3 more
europepmc   +1 more source