PPY‐Induced iCAFs Cultivate an Immunosuppressive Microenvironment in Pancreatic Cancer
Advanced Science, EarlyView.Pancreatic ductal adenocarcinoma features abundant stromal components that hinder therapy efficacy. Single‐cell RNA sequencing analysis combined with experiments identified PPY, a gastrointestinal hormone, as a novel inducer of immunosuppressive iCAFs. Mechanistic studies revealed that PPY activates the non‐canonical NF‐κB pathway via EGFR.
Mengdie Cao +14 more
wiley +1 more source
On Analysis And Generation Of Biologically Important Boolean Functions [PDF]
arXiv, 2014 Boolean networks are used to model biological networks such as gene regulatory networks. Often Boolean networks show very chaotic behavior which is sensitive to any small perturbations.In order to reduce the chaotic behavior and to attain stability in the gene regulatory network,nested canalizing functions(NCF)are best suited NCF and its variants have ...
arxiv
Antibacterial Efficacy of Cold Atmospheric Plasma, Photodynamic Therapy with Two Photosensitizers, and Diode Laser on Primary Mandibular Second Molar Root Canals Infected with Enterococcus faecalis: An In Vitro Study [PDF]
, 2023 Leyli Haghighi +3 more
openalex +1 more source
Advanced Science, EarlyView.This study explores the role of gemcitabine (GEM)‐resistant pancreatic cancer‐derived extracellular vesicles (EVs) in activating pancreatic stellate cells (PSCs) and promoting extracellular matrix production. GEM‐resistant cells release higher levels of asparagine (Asn), which triggers PSC activation. Long noncoding RNA sequencing identified linc‐ZNF25‐
Miao Yu +6 more
wiley +1 more source
Antimicrobial photodynamic therapy combined with conventional endodontic treatment to eliminate root canal biofilm infection [PDF]
, 2006 Aguinaldo Silva Garcez +5 more
openalex +1 more source
Advanced Science, EarlyView.Using a 3D tumor microenvironment (TME)‐on‐a‐chip model, tumor–stromal–immune crosstalk in triple‐negative breast cancer is studied, revealing the TME's combinatorial effect on cancer progression. Integrating single‐cell transcriptomic analysis demonstrates metabolic reprogramming via the kynurenine pathway, highlighting the complex TME cellular ...
Kalpana Ravi +7 more
wiley +1 more source
Application of biologics for ridge preservation/reconstruction after implant removal
Clinical Advances in Periodontics, Volume 12, Issue 4, Page 270-276, December 2022., 2022 Abstract Background The purpose of this review was aimed at providing the rationale supported with a series of cases to apply biologics to enhance orchestrating the healing process at implant removal sites. Summary Implant removal is commonly applied on a daily basis, in particular, in cases that exhibit esthetic failures linked to inadequate implant ...
Alberto Monje +1 more
wiley +1 more source
Validation of a track repeating algorithm for intensity modulated Carbon therapy with GEANT4 [PDF]
arXiv, 2018 The Fast Dose Calculator (FDC), a track repeating algorithm Monte Carlo method was initially developed for proton therapy. The validation for proton therapy has been demonstrated in a previous work. This method can be expanded to ion applications. Our purpose of this paper is to validate the FDC for carbon therapy.
arxiv
Photonic real-time monitoring of bacterial reduction in root canals by genetically engineered bacteria after chemomechanical endodontic therapy [PDF]
, 2007 Aguinaldo Silva Garcez +4 more
openalex +1 more source
Influencing factors and detection methods of microleakage in root canal therapy [PDF]
, 2023 Tingting Guo, Fanqi Meng, Jin Zhao
openalex +1 more source