Results 121 to 130 of about 66,198 (303)

Macrophage Extracellular Traps in Immunity and Cancer

Advanced Science, EarlyView.
As a macrophage‐mediated innate defense mechanism, the dysregulated release of METs drives chronic inflammation and influences tumor progression. Furthermore, METs exhibit a functional duality within the tumor microenvironment, capable of both promoting and suppressing tumor development.
Junyao Li, Eugenie Nepovimova, Adam Grundel, Lukas Peter, Qinghua Wu, Kamil Kuca   +5 more
wiley   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Integrating Spatial Proteogenomics in Cancer Research

Advanced Science, EarlyView.
Xx xx. ABSTRACT Background: Spatial proteogenomics marks a paradigm shift in oncology by integrating molecular analysis with spatial information from both spatial proteomics and other data modalities (e.g., spatial transcriptomics), thereby unveiling tumor heterogeneity and dynamic changes in the microenvironment.
Yida Wang, Yang Wu, Feng Zhang, Parthiban Periasamy, Haiyue You, Denise Goh, Rachel Elizabeth Ann Fincham, Xin Ning, Danping Wu, Lu Liu, Ying Jiang, Zhiwen Qian, Joe Yeong, Yan Zhang   +13 more
wiley   +1 more source

Potential Antimicrobial Methods for Provisionalizing Teeth After Endodontic Treatment [PDF]

, 2018
POTENTIAL ANTIMICROBIAL METHODS FOR PROVISIONALIZING TEETH AFTER ENDODONTIC TREATMENT By Laura T. Garden, DDS A thesis submitted in partial fulfillment of the requirements for the degree of Master of Science in Dentistry at Virginia Commonwealth ...
Garden, Laura T
core   +1 more source

Leveraging Macrophage Metabolic Reprogramming for Enhanced Anti‐Tumor Immunity

Advanced Science, EarlyView.
Tumor‐associated macrophages (TAMs) are key regulators of the tumor microenvironment (TME), with their metabolic states playing a critical role in tumor progression or regression. This review summarizes current understanding of TAM metabolic plasticity alongside cutting‐edge bioengineering innovations, outlining a roadmap for transforming the ...
Zhiyun Liu, Lingyao Zeng, Xulin Gan, Yilin Zhou, Han Shen, Dan Wu, Xin Shou, Minmin Jiang, Liyun Shi   +8 more
wiley   +1 more source

Shaping Ability of the Root Canal System Using Reciproc and Reciproc Blue in Preparation of Artificial Canals

Pesquisa Brasileira em Odontopediatria e Clínica Integrada
Objective: To evaluate the effect of repeated usage of Reciproc and Reciproc Blue on their shaping ability and to determine the maximum number of artificial canals that they can prepare until fracture.
Hawazin Majdi, Khalid Merdad, Tariq Abuhaimed, Lujain Mirdad, Omar Alkhattab, Abdulaziz Bakhsh   +5 more
doaj  

Five-canal maxillary first molar with calcified MB2 and low bifurcation of distal root canals: a case report

Frontiers in Oral Health
Root canal therapy is a highly regarded procedure, and failure to recognize the extremely variable anatomy of the maxillary first molars leads to unpredictable outcomes.
Xuandong Lin, Hongyu Xie, Hongyu Xie, Sijie Ruan, Xueling Ma, Jindong Long, Fangfang Xie   +6 more
doaj   +1 more source

Bisphosphonates and osteonecrosis of the jaw: pathogenetic hypothesis and new preventive measures [PDF]

, 2012
BRONJ is a serious oral complication of BP treatment involving the exposure of necrotic maxillary or mandibular bone. We investigated the pathogenetic hypothesis and new preventive measures for BRONJ in patients with bone metastases who received BP ...
FRANCINI, Filippo
core  

Ammonia Detoxification Inhibits Liver Metastasis by Reshaping Hepatic Microenvironment

Advanced Science, EarlyView.
Liver metastasis diverts aspartate into hyperactive pyrimidine synthesis, disrupting urea cycling and causing pathogenic ammonia accumulation. Ammonia dually reprograms the microenvironment by: (1) activating hepatic stellate cells (HSCs) into pro‐fibrotic metastasis‐associated fibroblasts (MAFs), and (2) suppressing anti‐tumor monocytes/macrophages ...
Sumin Sun, Haili Hu, Long Chen, Yuan Gao, Peng Sun, Liming Chen   +5 more
wiley   +1 more source

Endodontic surgical management of failed nonsurgical treatment: Report of a case

Journal of Oral Research and Review
The goal of root canal therapy is to eliminate any pulp tissue or bacteria from the canal to promote periapical tissue healing and successful root canal filling. Inadequate root canal shaping and cleaning as well as nonhermetic obturation are two factors
Vivek Thakur
doaj   +1 more source