Results 151 to 160 of about 171,329 (359)
Nuclear Factor I‐B Delays Liver Fibrosis by Inhibiting Chemokine Ligand 5 Transcription
Advanced Science, EarlyView.This study identifies the transcription factor Nuclear Factor I‐B (NFIB) as a key suppressor of liver fibrosis. NFIB expression declines during hepatic stellate cell activation, and its overexpression reduces fibrosis in mice models. The mechanism involves NFIB directly repressing chemokine C─C motif ligand 5 (CCL5), thereby alleviating oxidative ...
Qianqian Chen +14 more
wiley +1 more source
Endodontic Retreatment Of Mandibular Incisors With Root Canals Variations
International Dental JournalIntroduction: Mandibular incisors have been found to have a complex anatomy of the root canal system. Missed root canals are the most likely cause of treatment failure, and the persistent intra-radicular infections can lead to periapical lesion and ...
Kai Chen, Yuxia Shi, Ni Li
doaj +1 more source
Treatment of Abscessed Primary Molars Utilizing Lesion Sterilization and Tissue Repair: Literature Review and Report of Three Cases [PDF]
, 2014 Purpose: The purpose of this report was to review an emerging alternative treatment to pulpectomies and extractions for nonvital primary teeth called lesion sterilization and tissue repair (LSTR) and provide the results of three clinical case ...
Barbeau, Lori +2 more
core +1 more source
KRAS Withdrawal in Cholangiocarcinoma Leads to Immune Infiltration and Tumor Regression
Advanced Science, EarlyView.Cholangiocarcinoma (CCA) driven by oncogenic KRAS depends on its continuous activation for tumor maintenance. Using a conditional KRAS model, the authors show that turning off KRAS triggers rapid tumor regression accompanied by immune cell infiltration and cytokine release. The findings uncover a KRAS–senescence–immune signaling axis and highlight KRAS
Youwei Qiao +9 more
wiley +1 more source
Clinical Case ReportsMandibular incisors have been found to have a complex anatomy of the root canal system. Missed root canals are the most likely cause of treatment failure, and the persistent intra‐radicular infections can lead to periapical lesions and toothlessness ...
Kai Chen, Ni Li
doaj +1 more source
Tooth survival following non‐surgical root canal treatment: a systematic review of the literature [PDF]
, 2010 Y.‐L. Ng, Vera Mann, K. Gulabivala
openalex +1 more source
Endodontic management of an Infected Immature Tooth with Spontaneous Root Closure and Type II Dens Invaginatus: A Case Report [PDF]
, 2015 Apical periodontitis in an immature maxillary lateral incisor (#10) with arrested root development and a natural closure of the open apex in 22-year-old male was endodontically treated in a manner that conserved the existing hard tissue barrier (HTB).
Baker, Ryan W. +3 more
core
Connexin 26 Functions as a Direct Transcriptional Regulator During the Cochlea Development
Advanced Science, EarlyView.Connexin26 can not only form intercellular channels that mediate rapid communication on the cell membrane, but also enter the nucleus as a transcription factor to directly regulate the transcription of nuclear genes. In the developing cochlea, Cx26 can control the maturation of the molecular scissor ADAM10 by regulating the transcription of TspanC8 ...
Xiaozhou Liu +8 more
wiley +1 more source
Advanced Science, EarlyView.The article first reported that a murine mixed typical intrahepatic cholangiocarcinoma (iCCA)/sarcomatoid iCCA liver tumor model with 100% incidence of spontaneous extrahepatic metastasis and confirmed the occurrence of in mouse iCCA. Most importantly, EMT induced by the TGF‐β/ZEB1 axis does not influence tumor development or distant metastasis in this
Jingwen Wang +12 more
wiley +1 more source