Results 131 to 140 of about 64,469 (311)

Retrograde root canal treatment: A prospective case series

, 2017
Root canal treatment of teeth with necrotic pulps and apical periodontitis may be complicated by limited access to the root canals due to restorations and dystrophic calcifications.
Jonasson, Peter,, Lennholm, Camilla,, Kvist, Thomas,   +2 more
core   +1 more source

The Host Cell Factor Phosphatase‐2A Subunit PR130 Restricts Replication of Herpes Simplex Virus Type‐1

Advanced Science, EarlyView.
Molecular, genetic, virological, and biochemical analysis in combination with global proteome and phosphoproteome profiling and functional assays were applied to study the role of PR130 in the context of HSV‐1 replication. The observations reveal that host‐intrinsic mechanisms regulate HSV‐1 replication and highlight PR130 as a susceptibility factor of
Johannes Jungwirth, Christoph F. Jacob, Alexandra Nguyen, Mandy Beyer, Andreas O. Mieland, Mario Dejung, Jia‐Xuan Chen, Walburgis Brenner, Christina Ehrhardt, Andreas Henke, Oliver H. Krämer   +10 more
wiley   +1 more source

Three-dimensional CBCT analysis of bone remodeling, root resorption, and incisive canal morphology during miniscrew-assisted aligner-based incisor retraction with and without extractions

Frontiers in Oral Health
ObjectivesThis study aimed to investigate three-dimensional changes in incisive canal (IC) morphology, root–canal proximity, and root resorption following maxillary incisor (U1) retraction with clear aligners, comparing extraction and non-extraction ...
Remsh Khaled Al-Rokhami, Remsh Khaled Al-Rokhami, Zhihua Li, Deguo Gao, Xin Zhao, Jingke Liu, Hua Fan, Karim Ahmed Sakran   +7 more
doaj   +1 more source

Tumor‐Induced Splenic Remodeling: Mechanisms of Systemic Immunosuppression and Emerging Therapeutic Opportunities

Advanced Science, EarlyView.
ABSTRACT Despite the transformative impact of cancer immunotherapies such as immune checkpoint blockade, durable clinical responses remain limited. Increasing evidence indicates that antitumor immunity is governed not only by the tumor microenvironment, but also by systemic immune regulation mediated by peripheral immune organs. Among these, the spleen
Yuehua Liu, Xiaoqian Nie, Xiaofei Gao
wiley   +1 more source

Mechanisms of Pericyte‐Mediated Cancer Metastasis

Advanced Science, EarlyView.
Pericytes play multifarious roles in promoting cancer metastasis by facilitating metastatic cancer cell dissemination, circulating tumor cell survival, tissue extravasation, premetastatic niche formation, and metastatic tumor growth. These cells have intertwined interactions with vascular endothelial cells to modulate cancer cell behavior and ...
Ziheng Guo, Yihai Cao
wiley   +1 more source

Root Canal Re-treatment. Part 1: Why and When?

, 2023
\ua9 2023 George Warman Publications. All rights reserved.Both the anatomical challenges of root canal treatment and the variable clinical techniques employed mean that root canal re-treatment will sometimes be necessary.
Bonsor SJ, Gemmell A, Edwards D, Dowling N   +3 more
core  

Inhibition of Focal Adhesion Restricts Chemoresistance in Pancreatic Cancer by Targeting SLC7A11 Mediated Ferroptosis

Advanced Science, EarlyView.
FAK signaling drives chemoresistance and tumor evolution in pancreatic ductal adenocarcinoma. The FAK inhibitor IN10018 restores gemcitabine sensitivity by inducing SLC7A11‐mediated ferroptosis through the PI3K‐Akt pathway and remodeling the tumor microenvironment, reducing mesenchymal components while enhancing CD8+ T‐cell infiltration in preclinical ...
Yingjin Wang, Hui Yang, Baoyuan Zhang, Yongsu Ma, Kuangen Zhang, Peng Wang, Jiapeng Yang, Zaiqi Wang, Rong Liu, Xiaodong Tian, Ning Zhang, Yinmo Yang   +11 more
wiley   +1 more source

Microscopic Retreatment Of Mandibular Molar With C-Shaped Canal Configuration

International Dental Journal
Introduction: C-shaped root canals predominantly occur in the mandibular second permanent molars, characterized by their C-shaped cross-sectional anatomy.
Ruyue Wang, Lina Wang, Ao Lu, jinyue Hu, Qing Sun   +4 more
doaj   +1 more source

ACLY‐Driven Metabolic Reprogramming Promotes Histone Acetylation and Inflammation‐Associated Fibrosis in Chronic Kidney Disease

Advanced Science, EarlyView.
This study reveals a citrate–ACLY–H3K27ac metabolic–epigenetic axis driving inflammatory gene activation and kidney fibrosis, highlighting ACLY inhibition as a potential therapeutic strategy for chronic kidney disease (CKD). ABSTRACT The mechanisms by which metabolic stress drives epigenetic dysregulation and fibrosis in chronic kidney disease (CKD ...
Chunxiu Du, Dhanunjay Mukhi, Lingzhi Li, Chenyu Li, Siyu Pan, Bernhard Dumoulin, Eunji Ha, Lakshmi P Kolligundla, Yanjuan Hou, Jonathan Levinsohn, Chaelin Kang, Konstantin Adrian Klötzer, Junnan Wu, Samer Mohandes, Kathryn E Wellen, Katalin Susztak   +15 more
wiley   +1 more source

Relationship between unintentional canal overfilling and the long‐term outcome of primary root canal treatments and nonsurgical retreatments: a retrospective radiographic assessment

, 2019
Aim To determine retrospectively the long‐term radiographic outcome of root canal treatments and root canal retreatments with unintentional root canal overfilling.
Goldberg, F., Macchi, R. L., Cantarini, C., Arias Paniagua, Ana María, Alfie, D.   +4 more
core   +1 more source