Results 121 to 130 of about 169,948 (309)

A 3D In Vitro Model of the Human Hepatobiliary Junction

Advanced Science, EarlyView.
A 3D human organoid platform reconstructs the hepatobiliary junction between primary adult hepatocytes and intrahepatic cholangiocytes. These adult hepatobiliary organoids (aHBOs) support directional bile transport from canaliculi to ductule‐like structures, enable quantitative imaging of junction dynamics, and reveal cell‐type‐specific vulnerabilities
Ashley D. Westerfield, Katarzyna A. Grzelak, Katie Katsuyama, Vardhman Kumar, Bess M. Miller, Joa Yun, Jesse Kirkpatrick, David Mankus, Margaret E. Bisher, Abigail K.R. Lytton‐Jean, Z. Gordon Jiang, David D. Lee, Christopher S. Chen, Sangeeta N. Bhatia   +13 more
wiley   +1 more source

Perbedaan Ketahanan Fraktur Pasak Fiber Reinforced Composite tipe Smooth dan Serrated pada Gigi Pasca Perawatan Saluran Akar [PDF]

, 2018
Tooth that needs root canal treatment of necrosis. Root canal treatment is divided three stages, stage preparation of root canal biomechanical, stage cleaning and formation of a root canal with room entrances open pulpa of the sterilization phase, the ...
-, drg. Noor Hafida Widyastuti, Sp.KG, Isabella, Dara   +1 more
core  

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

Periapical healing after single-visit non-surgical endodontic retreatment in patients with hypertension: a retrospective study

Scientific Reports
This retrospective observational study aimed to investigate whether controlled hypertension (HT) is associated with radiographic periapical healing after single-visit non-surgical endodontic retreatment (Re-RCT) compared with systemically healthy ...
Tülin Doğan Çankaya, Merve Işık Aydın, Zeliha Uğur Aydın   +2 more
doaj   +1 more source

Treatment of a Young Maxillary Central Incisor with Two Root Canals: A Case Report

International Journal of General Medicine, 2021
Baize Zhang,1 Junhui Wang,1 Zhifei Zhou,2 Xin Ge,1 Geng Cheng,3 Yujiang Chen,1 Xiaojing Wang1 1State Key Laboratory of Military Stomatology & National Clinical Research Center for Oral Diseases & Shaanxi Key Laboratory of Stomatology, Department ...
Zhang B, Wang J, Zhou Z, Ge X, Cheng G, Chen Y, Wang X   +6 more
doaj  

Deciphering and Targeting the Schwannoma‐Neuron‐Macrophage Crosstalk for the Treatment of Schwannomatosis and Associated Pain

Advanced Science, EarlyView.
We established patient‐derived SWN cell lines and orthotopic PDX models that recapitulate patient pain phenotypes, alongside a novel intravital DRG imaging platform to track macrophage infiltration and neuronal pain responses. Using these models, we define HMGB1–CCL2–IL‐6 signaling crosstalk driving pain and identify EGF signaling as a key regulator of
Zhenzhen Yin, Limeng Wu, Yanling Zhang, Yao Sun, Grace Y. Lee, Simeng Lu, Xing Gao, John W. Chen, Sonu Subudhi, William Ho, Chao Zhu, Jun Ren, Gino B. Ferraro, Alona Muzikansky, Anat Stemmer‐Rachamimov, Jianren Mao, Scott R. Plotkin, Lei Xu   +17 more
wiley   +1 more source

Reparo de lesão periapical extensa após utilização de curativo de demora à base de hidróxido de cálcio: relato de caso [PDF]

PURPOSE: The objective of this paper is to report the clinical case of a patient who presented a chronic apical periodontitis, arising from internal inflammatory resorption followed by pulp necrosis, and a long-term success of a root canal therapy using ...
HERRERA, Helen, HERRERA, Henry, LEONARDO, Mário R, SILVA, Francisco Wanderley G de Paula e, SILVA, Léa A B   +4 more
core   +1 more source

Ultrasound Modulation of Visual Circuits in Mice Independent of Auditory Confound

Advanced Science, EarlyView.
In this study, Qiu et al. found that low‐intensity ultrasound can directly activate sparse ultrasound‐sensitive neurons (UNs) in the primary visual cortex (V1) of deafened mice. The proportion of these sparse UNs is pressure‐dependent. Furthermore, ultrasound modulates visual circuitry with distinct excitatory and inhibitory effects.
Jiaru He, Jiejun Zhu, Xinxin Wang, Zihao Chen, Jin Yang, Zhen Yuan, Hongzhi Xu, Lei Sun, Zhihai Qiu   +8 more
wiley   +1 more source

Impact of Delayed Completion of Previously Initiated Therapy and Provider Type on Outcomes of Root Canal Treatment [PDF]

, 2020
Objective:if the provider type influences long-term outcomes in instances where NSRCT has been previously initiated. The primary purpose of this study was to determine if the period of time between previously initiated therapy and the completion of non ...
Sulim, Igor
core   +1 more source

DMAP1 Deficiency Suppresses Lung Cancer Progression by Destabilizing Replication Fork and Activating IFN Signaling‐Mediated Anti‐tumor Immunity

Advanced Science, EarlyView.
Lung cancer remains the leading cause of cancer‐related death. We investigated the role of the epigenetic regulator DMAP1 in NSCLC and found that its loss induces replication stress and DNA damage. This in turn activates type I IFN signaling via the cGAS–STING pathway and transcriptional ISG de‐repression, enhancing anti‐tumor immune responses ...
Kan Huang, Xi Dai, Shuaihu Li, Yingxue Chen, Yaxin Yu, Lin Wang, Kun Liu, Shuhan Lyu, Chongyang Li, Yihua Sun, Fei Li   +10 more
wiley   +1 more source