Results 131 to 140 of about 407,625 (291)
Molecular Oncology, EarlyView.Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou +12 more
wiley +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Course Description:This course, developed by Mount Wachusett Community College, provides students with problem solving skills by exploring the process of conducting an investigation.
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ML driven root cause analysis (RCA) in telco microservices continuum
As microservice architectures continue to gain popularity, effective monitoring and Root Cause Analysis (RCA) solutions become crucial. This paper presents a Machine Learning Based Root Cause Analysis Framework (MALEAF) for carrying out RCA for service ...
Nigg, Silvan +4 more
core +1 more source
Molecular Oncology, EarlyView.Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen +14 more
wiley +1 more source
Root-cause analysis throughmachine learning in the cloud
, 2017 It has been predicted that by 2021 there will be 28 billion connected devices and that 80% of global consumer internet traffic will be related to streaming services such as Netflix, Hulu and Youtube.
Josefsson, Tim
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Bermuda Civil Society Project: Analysis of Social Service Agencies [PDF]
, 2010 Offers a research synthesis on Bermuda's nonprofit sector, including trends and challenges, landscape, and snapshots of the health, education, workforce, and youth violence issue areas; an analysis of agency priorities and data; and ...
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Molecular Oncology, EarlyView.Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy +10 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source