Results 111 to 120 of about 391,389 (248)

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Findings and recommendations from a root cause analysis of a clinical trial randomization error. [PDF]

J Clin Transl Sci
Hamidi M, Abbaas O, Bhatraju P, Debnath S, Gelfond J, Michalek JE, Nijland K, Watterson J, Zuniga Rapp M, Bates J, Schmidt S, Sharma K, Shay LA, Wan HD, Zozus M.   +14 more
europepmc   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Development of a national root cause analysis system for post-endoscopy upper gastrointestinal cancer. [PDF]

Endosc Int Open
Srinivasa A, Fiadeiro R, Gentry T, Goel S, Rahman T, Clements K, Chapman W, Burr N, Mukherjee D, Banks M, McCord M, Dhar A, Valori R, Trudgill N.   +13 more
europepmc   +1 more source

Graph-Free Root Cause Analysis

CoRR
Failures in complex systems demand rapid Root Cause Analysis (RCA) to prevent cascading damage. Existing RCA methods that operate without dependency graph typically assume that the root cause having the highest anomaly score. This assumption fails when faults propagate, as a small delay at the root cause can accumulate into a much larger anomaly ...
openaire   +2 more sources

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Application of Root Cause Analysis in Improving Care for Falls Associated With Cough Syncope. [PDF]

Clin Case Rep
Zhu F, Li Y, Liu L, Wang M.
europepmc   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

From Root Cause Analysis to Systems Thinking: A Comparative Content Analysis of Patient Safety Incident Investigation Reports in Mental Healthcare. [PDF]

J Eval Clin Pract
Challinor A, Bhandari S, Bifarin O, Morasae EK, Xavier P, Saini P, Berzins K, Nathan R.   +7 more
europepmc   +1 more source