Results 101 to 110 of about 407,625 (291)
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
Improving dependability by using root cause analysis
, 2019 Tämän tutkimuksen tavoitteena oli suunnitella juurisyyanalyysiprosessi, jota voidaan hyödyntää vikaantumisten analysoimisessa. Juurisyy tarkoittaa vikaantumisen perimmäistä syytä ja se voi olla tekninen, johtamisesta johtuva tai inhimillinen syy ...
Hovio, Ulrika
core
Iranian Journal of Nursing and Midwifery Research, 2015 Background: Many maternal deaths caused are due to preventable causes during pregnancy and childbirth. Therefore, the detailed analysis of the root causes provides developing a plan and appropriate interventions to prevent these deaths occurring in the ...
Marjan Beigi +4 more
doaj
Psychiatric Bulletin, 2005 We all look forward to Homicide Inquiries, mandated by the Department of Health Circular HSG(94)27 ([Department of Health, 1994][1]) being replaced or modernised as soon as possible, since there seems to be very little evidence that the enormous costs of these inquiries are justified by the ...
openaire +1 more source
Ubiquitination of secretory granules promotes their crinophagic degradation in Drosophila
FEBS Letters, EarlyView.Ubiquitination of secretory granules in Drosophila larval salivary glands is a critical molecular trigger for crinophagy, the lysosomal degradation of unreleased, or low‐quality granules. The E3 ubiquitin ligase Cnot4 is recruited to the surface of secretory granules to induce crinophagy.
Tamás Csizmadia +6 more
wiley +1 more source
Indian Journal of Endocrinology and Metabolism, 2017 Objectives: To identify system-based factors contributing to Emergency Department (ED) admissions of children with diabetic ketoacidosis (DKA) and related complications with emphasis on parental and physician awareness and prereferral management ...
Muralidharan Jayashree +4 more
doaj +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
ANTUSIASME GURU DALAM PROGRAM PENGEMBANGAN KOMPETENSI PEDAGOGIK DAN DETERMINANNYA *)
Kelola: Jurnal Manajemen Pendidikan, 2015 This study aimed to describe the enthusiasm of the teachers at SMPN 2 Gedangsari, Gunung kidul in the program of Education and Training (Dik-lat) for pedagogic competence development, organized by the Education Foundation of Astra-Michael D.
Donald Samuel
doaj +1 more source
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source