Results 111 to 120 of about 123,945 (292)

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Evaluation of the effect of EDTA on root coverage at free gingival graft procedure [PDF]

, 2018
Background: The present study has been designed to compare the effect of root surface biomodification with EDTA for the treatment of buccal gingival recession with free gingival graft. Materials and methods: This randomized controlled parallel ...
Bozan Serhat İzol, Devrim Deniz Üner, Fikret İpek, Öner, Devrim Deniz, Arpağ, Osman Fatih, ÜNER, DEVRİM DENİZ, Osman Fatih Arpağ, İpek, Fikret, İzol, Bozan Serhat   +8 more
core   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

A surgical approach to root coverage and correction of mucogingival conditions and deformities in mandibular incisors with isolated gingival recession: free mucogingival graft. A pilot prospective cohort study

© 2024 by Quintessence Publishing Co Inc. This document is the Published version of a Published Work that appeared in final form in International Journal of Periodontics & Restorative Dentistry.
Ortiz Ruiz, Antonio José, Moreno Rodríguez, José Antonio   +1 more
core   +1 more source

Effect of Er,Cr:YSGG Laser Root Conditioning on the Success of Root Coverage with Subepithelial Connective Tissue Graft: A Randomized Clinical Trial with a 6-Month Follow-Up

Frontiers in Dentistry, 2018
Objectives: Finding predictable approaches for root surface biomodification is an important challenge in the treatment of gingival recession. This study sought to assess the root coverage percentage by subepithelial connective tissue graft (SCTG ...
Banafsheh Poormoradi, Parviz Torkzaban, Leila Gholami, Amirarsalan Hooshyarfard, Maryam Farhadian   +4 more
doaj  

“United Pedicle Flap” for management of multiple gingival recessions

Journal of Indian Society of Periodontology, 2016
Numerous surgical procedures have evolved and are being modified with time to treat gingival recession by manipulating gingival or mucosal tissues in various ways.
Aditi Chopra, Karthik Sivaraman, Subraya Giliyar Bhat   +2 more
doaj   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Effectiveness of vestibular incision subperiosteal tunnel access technique in the treatment of multiple adjacent gingival recession defects: A systematic review

Journal of Indian Society of Periodontology
Objective: To investigate the effectiveness of Vestibular Incision Subperiosteal Tunnel Access (VISTA) technique over other root coverage (RC) procedures for treating Millers Class I and II multiple adjacent gingival recession defects (MAGRD).
Prabhnoor Tuli, Abhay Pandurang Kolte, Rajashri Abhay Kolte, Vrushali Nilesh Lathiya   +3 more
doaj   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source