Results 91 to 100 of about 123,945 (292)

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Clinical Remarks on the Significance of Tooth Malposition and Papillae Dimension on the Prediction of Root Coverage

, 2020
When it comes to complete root coverage of exposed root surfaces, several limiting factors have been suggested. Although tooth malposition and papillae dimension are capable of influencing root coverage, they have not received sufficient emphasis in the ...
Tavelli L., Zucchelli G., Cortellini P., Barootchi S., Wang H. -L., Stefanini M.   +5 more
core   +1 more source

Optimización del injerto conectivo subepitelial en la cobertura de recesiones gingivales múltiples contiguas. Presentación de un caso clínico Optimization of the subephitelial connective tissue graft to treat adjacent multiple gingival recessions. Clinical case presentation

Revista de la Asociación Odontológica Argentina, 2017
Resumen Objetivo: Describir, mediante un caso clínico, una técnica quirúrgica para la optimización del injerto conectivo libre subepitelial en la cobertura de recesiones gingivales contiguas múltiples.
Jennifer Romina Alberichi, Nelson Carranza   +1 more
doaj  

A Comparison of Clinical Effect for Root Coverage

The Journal of the Korean Academy of Periodontology, 2008
Purpose: The purpose of this study was to compare clinical effect of the Langer & Langer technique , the modified Langer & Langer technique and Bruno technique. Material and Methods: 30 patients who have gingiva recession(Miller class I or class II) were carried root coverage.
Jong-Soo Han, Ki-Seok Hong, Chin-Hyung Chung, Sung-Bin Lim   +3 more
openaire   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Root coverage of a previously restored tooth. A case report with a 7-year follow-up

, 2009
Alexander CorsairPrivate Practice, RockvilleCentre, NY, USAAbstract: This case report describes the treatment of a maxillary canine that had 4 mm of marginal gingival recession.
Alexander Corsair
core  

Cardioplastic Approach to Omental Flap Coverage for Severe Aortic Root Infections in the Opioid Era

, 2020
Aortic root abscesses are severe sequelae of endocarditis that clinically manifest as life-threatening infection. As the opioid epidemic continues to yield a national crisis, the incidence and severity of this disease process have increased ...
Bonaroti, Alisha R., Vasconez, Henry C., R. Wesley Edmunds, Ryan C. DeCoster, Alisha R. Bonaroti, Michael E. Sekela, Liau, James Y., Edmunds, R. Wesley, Sekela, Michael E., James Y. Liau, Henry C. Vasconez, DeCoster, Ryan C.   +11 more
core   +1 more source

Sub-epithelial connective tissue graft for root coverage in nonsmokers and smokers: A pilot comparative clinical study

Journal of Indian Society of Periodontology, 2016
Background: Gingival recession is a common condition and is more prevalent in smokers. It is widely believed that root coverage procedures in smokers result in less desirable outcome compared to nonsmokers', and there are few controlled studies in ...
Chini Doraswamy Dwarakanath, Bheemavarapu Divya, Gottumukkala Naga Venkata Satya Sruthima, Gautami Subadra Penmetsa   +3 more
doaj   +1 more source