Results 91 to 100 of about 6,155,597 (302)

RNA‐related functions of BRCA2 in transcription, replication, and genome stability

FEBS Letters, EarlyView.
Beyond its role in homologous recombination, BRCA2 regulates R‐loop homeostasis, DNA–RNA hybrid resolution, RNA polymerase II dynamics, and transcriptional activation. Disruption of any of these functions can contribute to genome instability, inflammatory signaling, and tumorigenesis. BRCA2 is a central tumor suppressor protein best known for its roles
Lucia Alvaro‐Aranda, Sreerama Chaitanya Sridhara, Aura Carreira   +2 more
wiley   +1 more source

The vertical distribution of the root system of the desert highway shelterbelt in the hinterland of the Taklimakan Desert [PDF]

, 2008
In this work, the vertical distribution of the root system in the Tarim Desert Highway shelterbelt under high salinity water drip irrigation was investigated. The effect of site condition and shelterbelt age was studied.
Xu, XW, Chinese Acad Sci, Xinjiang Inst Ecol & Geog, Urumqi 830011, Peoples R China, Wang YongDong, Wang XiaoJing, Lei JiangQiang, Li ShengYu, Xu XinWen   +5 more
core  

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Exploring the relationship between saturated hydraulic conductivity and roots distribution: two case studies in Garfagnana (Northern Tuscany, Italy) and Zollikofen (Bern, Switzerland)

Frontiers in Sustainability
Soil hydraulic conductivity and root distribution represent two important parameters toward the engineering applications, ranging from quantification of hydrological and geotechnical processes (e.g., water runoff, shallow landslides) to agricultural ...
Lorenzo Marzini, Michele Pio Papasidero, Enrico D’Addario, Massimiliano Schwarz, Leonardo Disperati   +4 more
doaj   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

The Distribution of the Latent Roots of the Covariance Matrix

The Annals of Mathematical Statistics, 1960
The distribution of the latent roots of the covariance matrix calculated from a sample from a normal multivariate population, was found by Fisher [3], Hsu [6] and Roy [10] for the special, but important case when the population covariance matrix is a scalar matrix, $\Sigma = \sigma^2I$.
openaire   +3 more sources

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

Range Unit Root (RUR) Tests: Robust against Nonlinearities, Error Distributions, Structural Breaks and Outliers. [PDF]

Since the seminal paper by Dickey and Fuller in 1979, unit-root tests have conditioned the standard approaches to analysing time series with strong serial dependence in mean behaviour, the focus being placed on the detection of eventual unit roots in an ...
Sipols, Ana E., Escribano, Álvaro, Aparicio, Felipe M.   +2 more
core  

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

FEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source

Saddlepoint Approximations for Optimal Unit Root Tests [PDF]

This paper provides a (saddlepoint) tail probability approximation for the distribution of an optimal unit root test. Under restrictive assumptions, Gaussianity and known covariance structure, the order of error of the approximation is given.
Patrick Marsh
core