Results 51 to 60 of about 10,849,141 (303)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

open access: yesFEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta   +3 more
wiley   +1 more source

Different root growth patterns in tomato seedlings grown hydroponically under an electric field [PDF]

open access: yes, 2013
Electric fields can determine changes at morphological and physiological levels in plants. In this study, seedlings of Solanum lycopersicum L., grown hydroponically in a floating system, were exposed to a DC 12.0 V m–1 electric field (EF).
SCOPA, Antonio   +7 more
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

open access: yesFEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang   +2 more
wiley   +1 more source

Root developmental responses to heterogeneous water and nitrogen supply [PDF]

open access: yes, 2012
Better understanding of the interaction between the soil physical properties determining water and nitrate availability and the root proliferation and gene expression components of nutrient acquisition could contribute to food security, but may have been
Chapman, N., CHAPMAN, NICHOLAS
core  

Improved root turnover assessment using field scanning rhizotrons with branch order analysis

open access: yesEcosphere, 2019
Root turnover is a key process contributing to soil carbon storage, nutrient cycling, and other ecosystem functions. However, quantifying root turnover rates remains highly uncertain and methodologically challenging.
Changfu Huo, Weixin Cheng
doaj   +1 more source

One-Point Optimal Family of Multiple Root Solvers of Second-Order

open access: yesMathematics, 2019
This manuscript contains the development of a one-point family of iterative functions. The family has optimal convergence of a second-order according to the Kung-Traub conjecture.
Deepak Kumar   +2 more
doaj   +1 more source

Structural and biochemical analysis of a B12 superbinder

open access: yesFEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices   +3 more
wiley   +1 more source

Research on formant estimation algorithm for high order optimal LPC root value screening

open access: yesTongxin xuebao, 2022
Objectives: The existing linear prediction (LP) formant estimation algorithms are difficult to locate formant precisely because of the pseudo root interference and interaction between poles.Because of the low order fitting formant of LP prediction,the ...
Hua LONG, Shumeng SU
doaj   +2 more sources

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

open access: yesFEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav   +2 more
wiley   +1 more source

The square root and the relations of order [PDF]

open access: yesTransactions of the American Mathematical Society, 1906
One of the most obvious discritninations between positive and negative numbers is that the former possess square roots in the field of reals while the latter do not. This distinction, however, has not yet beeln used in any of the current systems of postulates. On the contrary, an order relation,
openaire   +1 more source

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