Results 71 to 80 of about 545,174 (258)

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

Boolean Term Orders and the Root System Bn

open access: yesOrder, 1998
A boolean term order is a total order on subsets of [n]={1,...,n} such that \emptyset < alpha for all nonempty alpha contained in [n], and alpha < beta implies alpha \cup gamma < beta \cup gamma for all gamma which do not intersect alpha or beta.
openaire   +2 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Relationships between Nutrient Heterogeneity, Root Growth, and Hormones: Evidence for Interspecific Variation

open access: yesPlants, 2018
(1) Background: Plant roots respond to nutrients through root architecture that is regulated by hormones. Strong inter-specific variation in root architecture has been well documented, but physiological mechanisms that may control the variation have not.
Jia Dong, Robert H. Jones, Pu Mou
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

open access: yesMolecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge   +17 more
wiley   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

open access: yesMolecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel   +6 more
wiley   +1 more source

Convex Orderings in Affine Root Systems, II

open access: yesJournal of Algebra, 1996
The study of convex orderings in root systems started in the author's former paper [\textit{P. Papi}, Proc. Am. Math. Soc. 120, 661-665 (1994; Zbl 0799.20037)]. Clearly, it is associated with the PBW-bases for quantized enveloping algebras. In this paper, in the finite case, a combinatorial characterization of reflections, longest elements in standard ...
openaire   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

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