Results 81 to 90 of about 545,174 (258)

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

open access: yesMolecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic   +5 more
wiley   +1 more source

Soil nitrate drives fine root decomposition under nitrogen addition in a subtropical forest

open access: yesFrontiers in Forests and Global Change
Fine root decomposition is a key process influencing the element cycling of forest ecosystems and is sensitive to increasing atmospheric nitrogen (N) deposition.
Guantao Chen, Yuqin Chen, Xingzhu Yao
doaj   +1 more source

Six-Year Nitrogen–Water Interaction Shifts the Frequency Distribution and Size Inequality of the First-Order Roots of Fraxinus mandschurica in a Mixed Mature Pinus koraiensis Forest

open access: yesFrontiers in Plant Science, 2017
The variation in fine root traits in terms of size inequality at the individual root level can be identified as a strategy for adapting to the drastic changes in soil water and nutrient availabilities. The Gini and Lorenz asymmetry coefficients have been
Cunguo Wang   +9 more
doaj   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

open access: yesMolecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi   +7 more
wiley   +1 more source

Effects of Different Contact Lens Designs on Visual Quality Among the Soft Spherical Contact Lens Users

open access: yesTürk Oftalmoloji Dergisi, 2013
Purpose: To evaluate the effects of different lens designs on visual quality among soft spherical contact lens users. Material and Method: Forty eyes of twenty patients from our contact lens unit were included in this study.
Mustafa Demir   +2 more
doaj   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

open access: yesMolecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen   +14 more
wiley   +1 more source

Optimization of Tooth Root Profile Using Bezier Curve with G2 Continuity to Reduce Bending Stress of Asymmetric Spur Gear Tooth

open access: yesMATEC Web of Conferences, 2018
This research describes simple and innovative approach to reduce bending stress at tooth root of asymmetric spur gear tooth which is desire for improve high load carrying capacity.
Vaghela Priyakant, Prajapati Jagdish
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

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