Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source
Then jingle, jingle, jingle, jingle, Bells and hoofs are gay! [first line of chorus]
strophic with choruspiano and voice (satb chorus)656 5Johns Hopkins University, Levy Sheet Music Collection, Box 062, Item 005Geo.
core
Dissecting the Role of Serotonin in Drought Responses of Rocket Plants: From Serotonin Accumulation to Tryptophan-ABA Associations. [PDF]
Álvarez-Real S +2 more
europepmc +1 more source
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
Turkish adaptation and psychometric validation of the Normative Male Alexithymia Scale-Brief Form (NMAS-BF) among male university students. [PDF]
Özel İ.
europepmc +1 more source
ADP‐ribosylation: An emerging regulator of the epigenome
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho +2 more
wiley +1 more source
Effects of blood flow restriction training on cardiovascular autonomic function in middle-aged and older adults: a meta-analysis. [PDF]
Liu C, Zhang Z, Zhuang M, Liu T, Xie Y.
europepmc +1 more source
Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source
Depth-adapted portal design for unilateral biportal endoscopic discectomy in a morbidly obese patient (BMI 41): technical considerations. [PDF]
Arataki S +3 more
europepmc +1 more source
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic +10 more
wiley +1 more source

