Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner +7 more
wiley +1 more source
Nitrogen and Phosphorus Additions Alleviate Nitrogen Limitation in <i>Pinus yunnanensis</i> Seedlings by Reshaping Organ-Specific Stoichiometry. [PDF]
Li N, Liao J, Su X, Li X, Cai N, Xu Y.
europepmc +1 more source
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young +7 more
wiley +1 more source
The Enhancement of Abiotic Stress Tolerance in <i>Arabidopsis</i> via Heterologous Overexpression of <i>TcDHN1</i>, a Dehydrin Identified in the Recalcitrant Seeds of <i>Taxillus chinensis</i>. [PDF]
Qin Y +10 more
europepmc +1 more source
Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee +3 more
wiley +1 more source
Exclusion and Trapping Mechanisms of Boron in Forage Grasses Irrigated with Treated Oilfield-Produced Water. [PDF]
Al-Jabri K +5 more
europepmc +1 more source
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata +13 more
wiley +1 more source
Mass Spectrometry Imaging-Assisted Discovery of Gallotannin Biosynthetic Genes in the Root of Paeonia suffruticosa. [PDF]
Liu Y, Duan W, Tang W, Zhao Y, Li B.
europepmc +1 more source
Silicon at the Soil-Plant-Microbiome Interface: Rhizospheric Reconfiguration and Crop Resilience to Environmental Stresses. [PDF]
Boutafda A +4 more
europepmc +1 more source

