Results 181 to 190 of about 863,190 (311)

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Iatrogenic Root Perforations and Treatment Possibilities.

, 2019
Iatrogenic root perforations are an error made by the dentist where there is an artificial communication created between the periodontium and the root canal system.
Patel, Mayon
core  

Interaction of phosphorus and water supply regulates the maize root system and phosphorus-use efficiency. [PDF]

Front Plant Sci
Wang M, Xu J, Lyu Y, Luo M, Sun Y, Ye S, Cheng L, Rengel Z, Shen J.   +8 more
europepmc   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

The root system of Pappostipa frigida as a hotspot of active bacterial communities in the Andean steppe of the Atacama desert. [PDF]

Environ Microbiome
Palma DE, Schapheer C, Gaete A, Aravena P, Albarrán-Cuitiño C, Aguado-Norese C, González M, Cambiazo V.   +7 more
europepmc   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Diversity of root system architecture and root-shoot biomass allocation in industrial hemp (Cannabis sativa L.). [PDF]

PLoS One
Morales EY, Griffiths M, Mankar SP, Bagnall GC, Dowd TG, Fletcher R, McKay JK, Topp CN.   +7 more
europepmc   +1 more source

On root systems

, 1988
Two simple properties about root systems are proved. One of these properties is useful in the study of definability in certain nilpotent groups.
openaire   +2 more sources

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

A comparative analysis of root system characteristics, endogenous hormones, and transcriptome responses in tissue cultured ginger. [PDF]

BMC Plant Biol
Zhao X, Yuan J, Yu Y, Wu L, Wei L, Liu Y.   +5 more
europepmc   +1 more source