Results 91 to 100 of about 112,978 (300)

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Jatropha curcas L. Root Structure and Growth in Diverse Soils

The Scientific World Journal, 2013
Unlike most biofuel species, Jatropha curcas has promise for use in marginal lands, but it may serve an additional role by stabilizing soils. We evaluated the growth and structural responsiveness of young J.
Ofelia Andrea Valdés-Rodríguez, Odilón Sánchez-Sánchez, Arturo Pérez-Vázquez, Joshua S. Caplan, Frédéric Danjon   +4 more
doaj   +1 more source

Crop root system architecture in drought response

Journal of Genetics and Genomics
Drought is a natural disaster that profoundly impacts on global agricultural production, significantly reduces crop yields, and thereby poses a severe threat to worldwide food security. Addressing the challenge of effectively improving crop drought resistance (DR) to mitigate yield loss under drought conditions is a global issue. An optimal root system
Yanjun Zhang, Xi Wu, Xingrong Wang, Mingqiu Dai, Yunling Peng   +4 more
openaire   +2 more sources

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Simulation of wheat growth using the 3D root architecture model SPACSYS: validation and sensitivity analysis

, 2011
SPACSYS, a model of C and N cycling in the soil–plant–atmosphere continuum that incorporates a detailed three-dimensional root growth sub-model, was tested for its ability to predict the growth and root length density (RLD) distribution of winter wheat ...
Ian J. Bingham, Bingham, IJ, Wu, L, Lianhai Wu, Bingham, I. J., Wu, L.   +5 more
core   +1 more source

Image Analysis of Root System Architecture of Tomato Under Salinity [PDF]

, 2022
Plants have evolved a variety of strategies to deal with salt stress. The study focus has lately extended to also include root system architecture (RSA) plasticity in order to expose new salt tolerance features with potential breeding applications.
Nur Hanis, Haldi
core  

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

Root architecture and leaf photosynthesis traits and associations with nitrogen-use efficiency in landrace-derived lines in wheat

, 2022
Root system architecture (RSA) is important in optimizing the use of nitrogen. High-throughput phenotyping techniques may be used to study root system architecture traits under controlled environments.
Wells, D. M., Hawkesford, Malcolm J., Weerasinghe, Minuka, Pound, M. P., DeSilva, Jayalath, Kareem, S. H. S., Atkinson, Jonathan A., Foulkes, M. J., Foulkes, M. John, Weerasinghe, M., DeSilva, J., Pound, Michael P., Wells, Darren M., Kareem, Shadia H.S., Hawkesford, M. J., Atkinson, J. A.   +15 more
core   +1 more source