Results 101 to 110 of about 577,659 (302)

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

Evaluating dynamic partial reconfiguration in the integer pipeline of a FPGA-based opensource processor [PDF]

, 2008
This work explores the potential of sharing different arithmetic hardware operators tightly coupled to the integer pipeline of the open-source LEON3 processor.
Canagarajah, CN, Nabina, A, Nunez-Yanez, JL, Zaidi, SIH   +3 more
core   +2 more sources

Antibiofilm activity of a chionodracine‐derived peptide by NMR‐based metabolomics of cell‐free supernatant of Acinetobacter baumannii clinical strains

FEBS Open Bio, EarlyView.
KHS‐Cnd peptide is able to impair biofilm formation and disaggregate mature biofilms in Acinetobacter baumannii clinical isolates. Differences in extracellular metabolites reflect changes in biofilm metabolism due to KHS‐Cnd treatment. Among the differentially represented extracellular metabolites upon KHS‐Cnd treatment, the significantly altered ...
Fernando Porcelli, Enrico Landi, Francesco Maiurano, Irene Paris, Rosanna Papa, Marco Artini, Laura Selan, Stefano Borocci, Francesco Buonocore, Esther Imperlini   +9 more
wiley   +1 more source

A root system architecture measurement pipeline for apple rootstocks

Plant Phenome Journal
A robust root system architecture (RSA) is vital for tree health and fruit production of perennial fruit crops across diverse environments over many years. Consequently, RSA holds significant importance for fruit crop breeding programs.
Jean Sabety, Alicia Serrano, Awais Khan
doaj   +1 more source

Effect of solution pH on root architecture of four apple rootstocks grown in an aeroponics nutrient misting system

Frontiers in Plant Science
The pH of the solution in the rhizosphere is an important factor that determines the availability and mobility of nutrients for plant uptake. Solution pH may also affect the root distribution and architecture of apple rootstocks.
Ali Al Farqani, Lailiang Cheng, Terence L. Robinson, Gennaro Fazio   +3 more
doaj   +1 more source

The PROOF Distributed Parallel Analysis Framework based on ROOT

, 2003
The development of the Parallel ROOT Facility, PROOF, enables a physicist to analyze and understand much larger data sets on a shorter time scale. It makes use of the inherent parallelism in event data and implements an architecture that optimizes I/O ...
Ballintijn, Maarten, Brun, Rene, Rademakers, Fons, Roland, Gunther   +3 more
core  

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Enhancing drought resilience in durum wheat: effect of root architecture and genotypic performance in semi-arid rainfed regions [PDF]

PeerJ
Background Developing drought-adapted genotypes is a primary goal for achieving resilient agriculture in the Mediterranean region. Durum wheat, a widely grown crop in the drylands of the Mediterranean basin, would significantly benefit from increased ...
Ridha Boudiar, Abdelhamid Mekhlouf, Yacine Bekkar, Meriem Yessaadi, Adel Bachir, Larbi Karkour, Ana Maria Casas, Ernesto Igartua   +7 more
doaj   +2 more sources

Enzymatic degradation of biopolymers in amorphous and molten states: mechanisms and applications

FEBS Open Bio, EarlyView.
This review explains how polymer morphology and thermal state shape enzymatic degradation pathways, comparing amorphous and molten biopolymer structures. By integrating structure–reactivity principles with insights from thermodynamics and enzyme engineering, it highlights mechanisms that enable efficient polymer breakdown.
Anđela Pustak, Aleksandra Maršavelski
wiley   +1 more source