Results 61 to 70 of about 20,531,980 (258)
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
, 2014 This paper presents a general optimization model gleaned ideas from root growth behaviors in the soil. The purpose of the study is to investigate a novel biologically inspired methodology for complex system modeling and computation, particularly for ...
Zhu YL(朱云龙) +2 more
core +1 more source
Seminal root angle is associated with root system architecture in durum wheat
Food and Energy SecurityOptimal root system architecture (RSA) is critical for efficient resource capture in soils, hence being an interest in crop breeding. Seminal root angle (SRA) at the seedling stage in durum wheat has been suggested to be a good indicator of RSA. However,
Yichen Kang +10 more
doaj +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
HortScienceThe primary objective of this work was to generate species-specific information about root architectural adaptations to simulated natural levels of arsenic (As) during the establishment phase and onset of storage root formation in sweetpotato.
Arthur Villordon, Jack Baricuatro
doaj +1 more source
Frontiers in Plant Science, 2020 Climate change could alter plant aboveground and belowground resource allocation. Compared with shoots, we know much less about how roots, especially root system architecture (RSA) and their interactions, may respond to temperature changes.
Hongxia Luo +4 more
doaj +1 more source
T-DNA Insertion Lines with Altered Root System Architecture in Arabidopsis thaliana
, 2023 Root system architecture of plants is a complicated phenotype that is pivotal to processes as fundamental as acquisition of water and nutrients, stress tolerance and anchorage in soil.
Nikoumanesh, Kianoush +2 more
core
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
FEBS Letters, EarlyView.In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source
Development of a novel semi-hydroponic phenotyping system for studying root architecture
, 2011 A semi-hydroponic bin system was developed to provide an efficient phenotyping platform for studying root architecture. The system was designed to accommodate a large number of plants in a small area for screening genotypes.
Dunbabin, VM (15491186) +4 more
core +2 more sources