Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source
Integrated Transcriptomic and Metabolomic Analysis of Color Changes in Maize Root Systems Treated with Methyl Jasmonate. [PDF]
Biology (Basel)Zhang C, Zhang L, Guo H.
europepmc +1 more source
Genotypic Variability in Architectural Development of Mungbean (Vigna radiata L.) Root Systems and Physiological Relationships With Shoot Growth Dynamics. [PDF]
Front Plant Sci, 2021 Singh V, Bell M.
europepmc +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Identification of phenotypic and transcriptomic signatures underpinning maize crown root systems. [PDF]
Plant PhenomicsCallwood JB +9 more
europepmc +1 more source
Split-root systems: detailed methodology, alternative applications, and implications at leaf proteome level. [PDF]
Plant Methods, 2021 Saiz-Fernández I +3 more
europepmc +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Study on Shear Strength of Soil-Root Systems of Different Vegetation Types. [PDF]
Plants (Basel)Jian S, Niu Y, Zhang X, Wei Y, Gao J.
europepmc +1 more source
Plasmodiophora brassicae-Triggered Cell Enlargement and Loss of Cellular Integrity in Root Systems Are Mediated by Pectin Demethylation. [PDF]
Front Plant Sci, 2021 Stefanowicz K +8 more
europepmc +1 more source
Molecular Oncology, EarlyView.Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens +6 more
wiley +1 more source